Effect of Interaction Between Noise and A1166C Site of AT1R Gene Polymorphism on Essential Hypertension in an Iron and Steel Enterprise Workers

Abstract

Objective:This study aimed to analyze the interaction of Angiotensin II type 1 receptor (AT1R) gene polymorphism and occupational noise on the occurrence of essential hypertension (EH) in steel and iron enterprise men workers.Methods:A case control study of 935 iron and steel enterprise men workers was conducted, which included 312 cases of hypertension and 623 cases without hypertension. The noise at the workplace was assessed. Polymorphism of AT1R of the workers was examined using polymerase chain reaction - restriction fragment length polymorphism.Results:Polymorphism of AT1R (AC+CC vs. AA, odds ratio [OR] = 1.760, 95% confidence interval [CI]: 1.061∼2.920) and noise (greater than or equal to 85 dB(A),OR = 1.641, 95%CI: 1.225∼2.198) were independent determinants of EH using multivariate Logistic regression. Compared with AA carriers without noise, AC+CC interacted with noise (OR = 2.519, 95%CI: 1.254∼5.062) based on the multiplied model.Conclusions:AC+CC genotype of AT1R and noise were the risky factors of EH. These factors also interacted with each other.

Testing for Sufficient-Cause Interactions in Case-Control Studies of Non-Rare Diseases

“…Tong et al . mentioned in their paper 15 that the hypertension prevalence is 25.2% with a population size of 100,000. With this information and using the method presented in this paper, we calculated the log perils for the four exposure profile (Table 2 ).…”

“…We used Tong et al .’s 15 case–control data on essential hypertension to demonstrate our method. The case–control study assessed the effects of A1166C site of AT1R gene polymorphism ( AC + CC versus AA genotypes) and noise exposure ( versus <85 dB) on essential hypertension (see Table 2 ).…”

“…Based on a multiplicative model, Tong et al . 15 concluded that gene-noise multiplicative interaction may play a role for essential hypertension.…”

Develop and Evaluate a New and Effective Approach for Predicting Dyslipidemia in Steel Workers

“…China has a huge number of steel workers. Steel workers are a special occupational group, whose occupational environment is special, such as high temperature, noise, shift system and other special occupational exposure can cause or affect the occurrence of chronic diseases ( Chauhan et al, 2014 ; Hedén Stahl et al, 2014 ; Tong et al, 2017 ; Wu et al, 2019b ). Therefore, the prediction model of dyslipidemia in the general population is not suitable for steel workers.…”

Comprehensive Evaluation System of Occupational Hazard Prevention and Control in Iron and Steel Enterprises Based on A Modified Delphi Technique

“…At present, China has nearly 1000 large and medium-sized iron and steel plants, in which a large number of labor employees are assiduously occupied with contributing to the booming and flourishing development of China's iron and steel industry [3]. However, the industry can produce many occupational hazards during its production processes in combination with the large population base exposed to such occupational hazards [2,[4][5][6][7][8]. This scenario is more likely to result in numerous occupational diseases and potential economic losses [9][10][11][12].…”