Effect of Interaction of Methanol Leaf Extract of &lt;i&gt;Spondias mombin&lt;/i&gt; (Linn) and Amoxicillin on Some Diarrheagenic &lt;i&gt;Escherichia coli&lt;/i&gt;

Adegoke, Anthony A.; Aiyegoro, Olayinka Ayobami; Stenström, Thor-Axel

doi:10.4314/tjpr.v15i3.7

Cited by 10 publications

(9 citation statements)

References 19 publications

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“…An example of the 49 Syn-NPs-CAAs for EC is the methanolic extracts of edible plants Psidium guajava L., Persea americana Mill., Camellia sinensis L., Mangifera indica L., Coula edulis Baill., and Citrus sinensis L. [93]. Other plant extracts inhibited EC growth with focus on foodborne, hospital acquired infections and veterinary [117, 86, 29, 118, 119, 120, 30, 121, 122, 27, 123, 124, 100, 125, 126, 127, 128, 129, 92, 130, 48, 131, 132, 93, 133, 134, 135, 136, 137, 138, 99, 139, 93, 140, 141, 142, 143, 144, 95, 89, 145, 146, 147, 78, 80, 81, 82, 93].…”

Section: Resultsmentioning

confidence: 99%

Perspectives on the enhancement of commercially available antibiotics by natural products

Nitsch-Velasquez

Segura²,

Barrios

et al. 2022

Preprint

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Background: Opportunistic resistant bacteria are health and economically relevant in the health care systems and in industries worldwide, especially in the so-called resistant bacteria era (RBE). Enhancing the activity of commercially available antibiotics (CAAs) with di erent types of natural products (NPs) is a successful antimicrobial strategy, for instance the amoxicillin and clavulanate mixture. Objective: To nd research trends in this eld during 2015-2020 and to detect potential drug hits with potential to diversify formulations and materials design that can be useful to manage the RBE. Systematic review results: It yielded 190 reports of synergistic e ects of CAAs and NPs. The analyzed variables were: a) natural products origin: plant family, genera, secondary metabolite type; b) strains: +/- Gram, genera, most frequent species, application eld; and c) CAAs: family, most frequent CAAs. The families with potential to have more bioactive species were Apocynaceae, Rubiaceae, Euphorbiaceae (Isbio factor). Lonicera had the highest reports amount. Polyphenols and avonoids were the majority of pure NPs tested. Several potential drug hits for antibiotic activity enhancement at synergistic level were identi ed together with potential mechanisms of action: berberine (drug e ux inhibitor{DEI, bio lm inhibitor{BI), curcumin (BI), essential oils (BI), 3-o-metyl-butylgallato (inhibition of fatty acid saturation), among others. About the half of the tested strains were gram positive, being Methicillin Resistant Staphylococcus aureus (MRSA) the most frequently tested. Escherichia coli was the gram negative strain most frequently reported, including enterotoxigenic and extended spectrum beta-lactamases producers. The growth of other foodborne genera strains, such as Listeria and Salmonella, were also inhibited. Aminoglycosides were the family most reported, with gentamicin as the most commonly studied. Conclusions: NPs as either as plant extracts from a variety of families, or as puri ed compounds specially avonoids and polyphenols, have shown e ective results to enhance the antibiotic activity of CAAs against gram positive and negative strains relevant to HC and FI. Their mechanisms of action are starting to be determined, as the case EPIs and BIs. Further research is needed to achieve co-formulations and materials design useful for those elds, that can certainly be positively impacted by pursuing this strategy.

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Section: Resultsmentioning

confidence: 99%

Perspectives on the enhancement of commercially available antibiotics by natural products

Nitsch-Velasquez

Segura²,

Barrios

et al. 2022

Preprint

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“…Development, v. 9, n. 12, e12791210845, 2020 (CC BY 4.0) | ISSN 2525-3409 | DOI: http://dx.doi.org/10.33448/rsd-v9i12.10845 Even though this is a pioneering study in the evaluation of the modification of As present in the literature, antibiotics that inhibit protein synthesis, such as aminoglycosides, are among those that most present synergistic effects when associated with natural products to fight resistant bacteria, however, the mechanism by which this occurs has not yet been elucidated (Adwan;Abu-Shanab & Adwan, 2009;Saraiva et al, 2011;Shaeer et al, 2019). Adegoke, Aiyegoro & Stenstrom (2016), when analyzing the interaction between the methanolic extract of S. mombin leaves with amoxicillin (beta-lactam) on diarrhogenic strains of E. coli (DEC), noticed that the extract-antibiotic combination was more effective against the E. coli (ETEC) enterotoxygenic strain than the isolated drug, increasing the zone of inhibition from 15.1 to 21.5 mm, and the result validated by the checkerboard and time-kill methods. For the enteroinvasive (EIEC) and enterohemorrhagic (EHEC) strains the results were indifferent.…”

Section: 3 4 5 6 2 3 4 5 6 3 Results and Discussionmentioning

confidence: 99%

Antibacterial and antioxidant potential of Spondias tuberosa Arruda (Anacardiaceae) extracts

Santos

Carneiro

Andrade-Pinheiro

et al. 2020

RSD

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Antimicrobial resistance and the consequent inefficiency of antibiotics are the main problems faced by medicine. In view of this, numerous researches have been aimed at looking for new agents with antibacterial activity, among them natural products. Thus, this study aims to evaluate the antioxidant activity of aqueous and hydroalcoholic extracts of the leaves and roots of Spondias tuberosa by Thin Layer Chromatography (TLC), as well as to verify the antibacterial action of the extracts alone and in combination with commercial antibiotics to evaluate its potential in action of change of antibiotics. The extracts showed polar and nonpolar phenolic substances with antioxidant action. The Minimum Inhibitory Concentration (MIC) of the hydroalcoholic extracts of the leaves and roots was 1,024 μg/mL compared to the Staphylococcus aureus 25923 strain, whereas with the other strains, the products showed an MIC ≥ 2,048 µg/mL. The effect of combining extracts with amikacin, ampicillin and norfloxacin against the multidrug-resistant bacteria Escherichia coli 06, Staphylococcus aureus 10 and Pseudomonas aeruginosa 24 resulted in synergistic effects with aminoglycoside alone, achieving up to 75 % reduction in the MIC of the antibiotic. In view of the results obtained, it can be concluded that the extracts of S. tuberosa presented polar and nonpolar phenolic substances, in the antibacterial activity it can positively modify the effect of the aminoglycoside antibiotic against multi-resistant bacteria, but future studies are necessary to discover the mechanism of action of such an effect.

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“…Similarly, the methanolic extract of Olae showed antibacterial activity similar to that of the antibiotic amoxicillin against P. aeruginosa [34]. In addition, the methanol extract of Spondias mombin showed excellent antibacterial activity with a mean zone of inhibition ≥11.1 and activity index of 0.8 -1.1 [35]. The antimicrobial effect of any extract depends on the used method for extraction, the used solvents and the used plant.…”

Section: Discussionmentioning

confidence: 99%

Synergistic Effect of the Methanolic Extract of Lemongrass and Some Antibiotics to Treat Urinary Tract Bacteria

Noor¹

2016

JBM

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Some medicinal plants are used traditionally in Saudi Arabia to treat many bacterial infections. Three plants, lemongrass (Oymbopogon citrates), lantana (Lantana camara), and wild olive leaves (Olea europaea) were collected, identified, extracted with either hot water or organic solvents (methanol, diethyl ether, ethyl acetate and n-butanol) to investigate their antibacterial activities against E. coli. The methanol extracts of lemongrass, lantana and olive showed the highest activities against Esherichia coil while aqueous extract exhibited the lowest activities. Thus, the antibacterial activities of the methanolic extract of the three tested plants were determined using agar well diffusion method against some bacterial pathogens, isolated from urine samples. The highest antibacterial activity was recorded for themethanolic extract of lemongrass against all tested bacteria, E. coli, K. pneumoniae, P. aeuroginosa, P. mirabilis, E. faecalis and S. aureus. The tested bacteria differed with regard to their susceptibility to plant extracts. Lemongrass was the most active extract followed by lantana and wild olive extracts. Minimal inhibitory concentrations (MICs) of the methanolic extract of Lemongrass and some used antibiotics, Erythromycin, Tetracycline, Amoxicillin, Ciprofloxacin and Chloramphenicol were determined usingfluorescein diacetate method. Synergistic effect of the methanolic extract of lemongrass with the previous antibiotics against the tested clinical bacterial isolates was determined and the Fractional inhibitory concentrations (FIC) of different combination of the extract and the antibiotics were determined. FIC index (FICI) was calculated and it was ranged from 0.08 -0.98. The interaction between the tested plant extract and the tested antibiotics was either synergistic or additive effects and no antagonistic effect was recorded. In conclusion, methanolic extract of lemongrass singly or in combination with some antibiotics can be used to treat pathogenic bacteria that cause urinary tract infections.

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Effect of Interaction of Methanol Leaf Extract of <i>Spondias mombin</i> (Linn) and Amoxicillin on Some Diarrheagenic <i>Escherichia coli</i>

Abstract: Purpose: To study the effect of interaction between methanol leaf extract of Spondias mombin and amoxicillin on diarrheagenic Escherichia coli (DEC (50 -200, 12.5 and 6.25 mg/mL, respectively)

Cited by 10 publications

References 19 publications

Perspectives on the enhancement of commercially available antibiotics by natural products

Perspectives on the enhancement of commercially available antibiotics by natural products

Antibacterial and antioxidant potential of Spondias tuberosa Arruda (Anacardiaceae) extracts

Synergistic Effect of the Methanolic Extract of Lemongrass and Some Antibiotics to Treat Urinary Tract Bacteria

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