Effect of interesterified dietary fat mixtures on various lipid indices and liver metal content of rats in fat‐metabolism disturbance

Zsinka, A.; Perédi, J.; Lindner‐Szotyori, K.; Bíró, G.

doi:10.1002/food.19880320903

Cited by 2 publications

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“…With the technological change, namely with the interesterification of only one component (the lard) in the fat mixture, we obtained a more favourable effect than in our former experiments [7] when the whole fat-mixture was interesterified. Similar, or in some cases even more favourable lipid levels were found as an effect of the partial interesterification than with the noninteresterified fat mixture.…”

Section: Discussioncontrasting

confidence: 47%

“…According to our earlier results obtained in experiments modelling disturbances of fat metabolism [7], a diet with an interesterified 20 % fat mixture (containing lard: sunflower oil = 65 : 35) increased in a higher degree the total lipids, triglyceride and total cholesterol contents of the liver than a fat mixture of similar composition without interesterification. We suggested that this phenomenon was due to the fact that the fatty acid regroupings in the triglyceride structure developed in both of the fats, and from the biological point of view their "random" distribution was unfavourable.…”

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confidence: 83%

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Effect of interesterified fat mixtures on certain lipid indices in experimental fat metabolism disturbance

Zsinka

Perédi²,

Szépvölgyi

et al. 1989

Nahrung

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Groups of adult Wistar male and female rats were fed isoenergetically for a three and a six weeks period either with synthetic lipogenic diet containing 5% and 20% fat mixtures (in which sunflower oil and lard were blended according to the ratio of 35:65) or with the same synthetic diet containing the mixture of sunflower oil and interesterified lard in a similar ratio. A control group received a normal diet for 6 weeks, whereas one of the experimental groups (fed with the 20% fat mixture in the lipogenic diet for 6 weeks) was given the normal diet for an additional two weeks period. After the feeding periods had been completed serum HDL-C levels and the total lipid, triglyceride, total cholesterol, free fatty acid levels were determined in serum and liver. The distribution of fatty acids in liver and heart muscle was also evaluated. In comparison to the control values it has been found: 1. Consumption of the lipogenic diet which is known to increase the serum total lipid and total cholesterol content induced in male rats a smaller augmentation in these indices when consuming the 20% fat mixture with a P/S ratio approaching the ideal 1 values, than in case of a 5% fat mixture consumption. In case of female rats, considerable increases of the serum values, could be observed at both fat consumption levels. The serum triglyceride and HDL-C contents decreased for all experimental groups. 2. The total lipid and triglyceride content of the liver increased in a high degree, the fatty liver syndrome was developed--more rapidly in males than in females. The total lipid, triglyceride and total cholesterol contents of the liver of male rats exceeded those of females by 15-30%. 3. The interesterification of the lard component of fat mixture resulted in lipid indices similar to those without interesterification, or in certain cases, they were found to be even slightly more favourable, i.e. the biological effect of the technological change proved to be adequate. 4. After a two weeks regeneration period the serum values of the male rats approached closer the normal control values than those of the females which were decreasing from a very high level but the degree of decrease was greater for them than for the male rats. The lipid content of the liver showed similar values.(ABSTRACT TRUNCATED AT 400 WORDS)

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Section: Discussioncontrasting

confidence: 47%

mentioning

confidence: 83%

Effect of interesterified fat mixtures on certain lipid indices in experimental fat metabolism disturbance

Zsinka

Perédi²,

Szépvölgyi

et al. 1989

Nahrung

Self Cite

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Correlation Between Serum Cholesterols and Trace Element Uptake in Liver, Kidney, and Blood of Hypercholesterolemic Mice

Weginwar

Enomoto

Hirunuma

et al. 2002

BTER

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The radioactive multitracer technique was applied to the simultaneous determination of the uptake of 17 trace elements (Be, Na, Sc, V, Cr, Mn, Fe, Co, Zn, As, Se, Rb, Sr, Y, Zr, Nb, and Ru) in the liver, kidney, and blood of hypercholesterolemic model mice. The uptakes of Be, Sc, V, Cr, Fe, As, Rb, Y, Zr, Nb, and Ru in liver increased with an increasing feeding period of a cholesterol-rich diet, whereas the uptakes of Zn and Se decreased. Feeding of the diet resulted in a marked increase in serum total cholesterol, triglycerides, and low-density lipoprotein cholesterol. The metabolism of trace elements between cholesterolemic and normal mice was compared with respect to their serum cholesterol levels. A significant positive correlation was found between the concentration of serum triglycerides and liver uptakes of Cr, Fe, and As and a negative correlation for the uptake of Zn. A significant positive correlation was found between the concentrations of serum high- and low-density lipoprotein cholesterols and kidney uptakes of Cr and Rb. A negative correlation was found between the uptake of Be in the blood and the concentration of serum triglycerides. These results suggest that cholesterolemia have some specific effects on the metabolism of some elements.

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Effect of interesterified dietary fat mixtures on various lipid indices and liver metal content of rats in fat‐metabolism disturbance

Cited by 2 publications

References 3 publications

Effect of interesterified fat mixtures on certain lipid indices in experimental fat metabolism disturbance

Effect of interesterified fat mixtures on certain lipid indices in experimental fat metabolism disturbance

Correlation Between Serum Cholesterols and Trace Element Uptake in Liver, Kidney, and Blood of Hypercholesterolemic Mice

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