Effect of intermittent light on photoreceptor cells in the rabbit retina

Esfandiari, Arash; Yousofi, Alireza; Dehghan, Asghar; Ali, Safavi

doi:10.1007/s10384-009-0721-4

Cited by 9 publications

(6 citation statements)

References 10 publications

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“…Pyknotic and karyolytic nuclei resulted in damage to photoreceptor cells. These results are consistent with those of Esfandiari et al (1) and White and Fisher (7).…”

Section: Discussionsupporting

confidence: 95%

“…Therefore, it is reasonable to hypothesize that disorganization and loss of the outer segment may occur in the retina, and that phospholipid peroxidation products may serve as signaling molecules for retinal pigmented epithelium phagocytosis (22). These findings agree with those of Organisciak et al (2) and Esfandiari et al (1). Our observation in the EXP-II group indicated that damage including vacuolization, loss of mitochondrial crista, and cell swelling had occurred in the inner segment.…”

Section: Discussionsupporting

confidence: 93%

“…It has been reported that exposure of rabbits to bright light with different intensities causes damage to the photoreceptor layers in the retina (1). In addition, earlier reports by Organisciak et al (2) suggested that retinal light damage occurs in rats exposed to intermittent light.…”

Section: Introductionmentioning

confidence: 97%

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The effect of flashed light on the ultrastructure of the retinal photoreceptor cells in rabbit: a transmission electron microscope study

Esfandiari¹,

Posti²,

Dehghan³

et al. 2013

Turk J Vet Anim Sci

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The effects of light exposure on the retina have been carefully considered in recent years. The purpose of the current study was to investigate the effect of flashed light with low and high intensity on the photoreceptor layer of rabbit. Fifteen adult male New Zealand White rabbits were randomly divided into 3 groups: a control group, experimental group I (exposed to 60 W of flashed light 5 times), and experimental group II (exposed to 1000 W of flashed light 5 times). The retinas of the eyes were removed and studied by transmission electron microscope. The photoreceptor layer damage in experimental group II contained outer segment loss, vacuolated and disorganized mitochondria, vacuolization, cell swelling, and pyknotic, karyorrhexis, and karyolytic nuclei. The results suggested that high-intensity flashed light (1000 W) caused more photoreceptor layer damage than low-intensity light (60 W).

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“…Pyknotic and karyolytic nuclei resulted in damage to photoreceptor cells. These results are consistent with those of Esfandiari et al (1) and White and Fisher (7).…”

Section: Discussionsupporting

confidence: 95%

Section: Discussionsupporting

confidence: 93%

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The effect of flashed light on the ultrastructure of the retinal photoreceptor cells in rabbit: a transmission electron microscope study

Esfandiari¹,

Posti²,

Dehghan³

et al. 2013

Turk J Vet Anim Sci

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“…It converts light into electrical impulses to begin the visual process [11][12][13][14]. Retina plays an important role in the visual system.…”

Section: Introduction Introductionmentioning

confidence: 99%

Morphological study of retinal neurons after continuous exposure to fluorescent light in adult male albino rats

Gawish

Azmy

Abdallah

2011

The Egyptian Journal of Histology

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Retinal function depends on light trapping. However, continuous exposure to light may cause damage to the highly vulnerable retinal structure. Aim of the study This study aimed to investigate the possible histological alterations that might occur in the retinal neurons as a result of continuous exposure to fluorescent light in adult male albino rats. Materials and methods Ten healthy adult male albino rats were equally divided into two groups: a control group and a light-exposed group. Rats of control group were kept in 12 h light/12 h dark for 12 weeks. Rats of light-exposed group were put in top-opened cages illuminated by white fluorescent bulbs continuously for 1 week and then were kept in 12 h light/12 h dark for the following 11 weeks. The retina was extirpated and processed for examination by light and electron microscopy. The thickness of outer nuclear, inner nuclear, outer plexiform, and inner plexiform layers was estimated morphometrically and was statistically analyzed. ResultsFluorescent light-exposed neural retina revealed that photoreceptor outer segments were markedly disorganized and inner segments were short and less condensed. Outer nuclear layer contained few photoreceptors with marked intercellular spaces. Inner nuclear layer showed wide spaces between its neurons, with some of them having shrunken nuclei and others having disintegrated nuclei. Mü ller cells with deeply stained bodies and processes were seen in inner and outer nuclear layers. Many ectopic neurons were detected in the inner plexiform layer. Ganglion cell layer mostly contained deeply stained glial cells and few ganglion neurons. Nerve fiber layer showed an apparent increase in thickness. The estimated and analyzed thickness of the outer nuclear, inner nuclear, outer plexiform, and inner plexiform layers confirmed the results. ConclusionContinuous exposure to fluorescent light triggered retinal remodeling, including neuronal loss, reactive gliosis with neuronal and glial cells migration. This may lead to visual impairment.

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“…The photoreceptor layer of the rat is similar to that ofother animals (Esfandiari et al, 2009;Goodarzi et al, 2014;Garcia & Dejuan, 1999;Haacke et al, 2001).In this research,the injury produced by formaldehyde injection and improvement by erythropoietin injection were evaluated by transmission electron microscope. The rats injected with formaldehyde showed disorganization and vacuolization of the outer segment, high vacuolization of the inner segment, disappearance of cristae of mitochondria, pyknotic and karyolysis in outer nuclear layer.…”

Section: Discussionmentioning

confidence: 94%

The protective effects of erythropoietin on photoreceptor damage by formaldehyde

et al. 2016

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Effect of intermittent light on photoreceptor cells in the rabbit retina

Abstract: These observations suggest that intermittent high-intensity light causes more damage in the photoreceptor layer of the rabbit than does intermittent low-intensity light.

Cited by 9 publications

References 10 publications

The effect of flashed light on the ultrastructure of the retinal photoreceptor cells in rabbit: a transmission electron microscope study

The effect of flashed light on the ultrastructure of the retinal photoreceptor cells in rabbit: a transmission electron microscope study

Morphological study of retinal neurons after continuous exposure to fluorescent light in adult male albino rats

The protective effects of erythropoietin on photoreceptor damage by formaldehyde

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