Effect of   Intermittent Normobaric Hypoxia    Exposures on  Acute Mountain Sickness During Acute Ascent to 3500 m in Indian  Military Personnel

Bhaumik, Gopinath; Dass, Deepak; Ghosh, Dishari; Kumar, Harish; Kumar, Sanjiva; Kumar, Utkarsha; Reddy, M Padmanabh; Kumar, Bhuvnesh; Singh, Shashi Bala

doi:10.14429/dlsj.3.12906

Cited by 7 publications

(3 citation statements)

References 15 publications

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“…13 Training in intermittent normobaric hypoxia at sea level and its effect on HA illness like AMS is very limited. 14 Recent study from this laboratory on IHE indicated that normobaric hypoxic exposure at sea level significantly reduces AMS during subsequent exposure to hypobaric hypoxia at 3500 m altitude 15 and also helps in rapid acclimatization process. 16,17 However, no systemic study appears to have been carried out, particularly about the effect of intermittent normobaric hypoxia on basal physiological parameters during acute induction by air to 3500m and 4000m altitudes on initial days of acclimatization.…”

Section: Effect Of Intermittent Normobaric Hypoxia Exposure On Acclimatization To High Altitude By Air Inductionmentioning

confidence: 99%

Effect of intermittent normobaric hypoxia exposure on acclimatization to high altitude by air induction

et al. 2021

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Background: In emergency like condition, defence personnel are deployed to high altitude without proper acclimatization. Maladaption at high altitude leads to high altitude illness like acute mountain sickness (AMS), high altitude pulmonary edema (HAPE) and high-altitude cerebral edema (HACE) which hampers the operational capabilities. Aims and Objectives: The aim of the present study was to assess the effect of intermittent normobaric hypoxia exposure (IHE) at sea level on different physiological responses during initial days of acclimatization at 3500m and 4000m altitudes in acute induction. Materials and Methods: The IHE subjects were exposed to 12% FIO2 (equivalent altitude 14500 ft) for 4 hrs/day for 4 consecutive days at sea level and 5th day they were inducted by air to 3500m altitude. Baseline recording of different physiological parameters like cardiovascular, respiratory, oxygen saturation and AMS score were measured at sea level as well as 3500m altitude on daily basis for 6 days to assess acclimatization status. To confirm acclimatization status at 3500m, on fifth day the IHE group subjects were transported by road to 4000m and again measured different basal physiological parameters (like cardiovascular, oxygen saturation and AMS score) for four consecutive days. Results: Different physiological parameters of IHE treated group were stabilized by day 4 of air induction at 3500m altitude. Whereas, at 4000m altitude, these parameters were stabilized by day 2 of induction. Conclusion: Acclimatization schedules of four days at 3500m and two days at 4000m are essential to avoid malacclimatization/or high-altitude illness.

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Section: Effect Of Intermittent Normobaric Hypoxia Exposure On Acclimatization To High Altitude By Air Inductionmentioning

confidence: 99%

Effect of intermittent normobaric hypoxia exposure on acclimatization to high altitude by air induction

et al. 2021

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“…All the study protocols were approved by institutional ethical committee (Institutional Ethics Committee, Defence Institute of Physiology &Allied Sciences: IEC/DIPAS/09/DIP-251) which is in accordance to Helsinki declaration for human studies and informed written consent was obtained from all the volunteers. The basal parameters of the volunteers were recorded at Delhi (Baseline group) and subjects were exposed to normobaric hypoxia (12% FIO 2 for 4 h per day; equivalent altitude 4350 m) with pre-hypoxia and post-hypoxia challenges (13.5% FIO 2 for 1 h; equivalent altitude 3500 m) as described previously 33 . The volunteers were air lifted to Leh (3,520 m) the following day of post-hypoxia challenge and continuously monitored at days 4 (Post IHT-HAD4) and 7 (Post IHT-HAD7) respectively.…”

Section: Experiments Design and Sample Collectionmentioning

confidence: 99%

Intermittent hypoxia modulates redox homeostasis, lipid metabolism associated inflammatory processes and redox post-translational modifications: Benefits at high altitude

Gangwar

Paul

Ahmad

et al. 2020

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Intermittent hypoxia, initially associated with adverse effects of sleep apnea, has now metamorphosed into a module for improved sports performance. The regimen followed for improved sports performance is milder intermittent hypoxic training (IHT) as compared to chronic and severe intermittent hypoxia observed in sleep apnea. Although several studies have indicated the mechanism and enough data on physiological parameters altered by IH is available, proteome perturbations remain largely unknown. Altitude induced hypobaric hypoxia is known to require acclimatization as it causes systemic redox stress and inflammation in humans. In the present study, a short IHT regimen consisting of previously reported physiologically beneficial FIO2 levels of 13.5% and 12% was administered to human subjects. These subjects were then airlifted to altitude of 3500 m and their plasma proteome along with associated redox parameters were analyzed on days 4 and 7 of high altitude stay. We observed that redox stress and associated post-translational modifications, perturbed lipid metabolism and inflammatory signaling were induced by IHT exposure at Baseline. However, this caused activation of antioxidants, energy homeostasis mechanisms and anti-inflammatory responses during subsequent high-altitude exposure. Thus, we propose IHT as a beneficial non-pharmacological intervention that benefits individuals venturing to high altitude areas.

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“…Intermittent Hypoxia training (IHT), on the other hand, is considered as a non pharmacological intervention for high altitude related health problems in humans ( Bhaumik et al, 2018 ; Muza, 2007 ). Intermittent hypoxia (IH) can be defined as periodic exposure to hypoxia lasting for minutes to days, interrupted by return to normoxia or less hypoxic conditions ( Powell and Garcia, 2000 ).…”

Section: Introductionmentioning

confidence: 99%

Elucidating the combined effect of intermittent hypoxia training and acetazolamide on hypoxia induced hematological and physiological changes

Nimje

Patir

Tirpude

et al. 2022

Current Research in Physiology

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Effect of Intermittent Normobaric Hypoxia Exposures on Acute Mountain Sickness During Acute Ascent to 3500 m in Indian Military Personnel

Cited by 7 publications

References 15 publications

Effect of intermittent normobaric hypoxia exposure on acclimatization to high altitude by air induction

Effect of intermittent normobaric hypoxia exposure on acclimatization to high altitude by air induction

Intermittent hypoxia modulates redox homeostasis, lipid metabolism associated inflammatory processes and redox post-translational modifications: Benefits at high altitude

Elucidating the combined effect of intermittent hypoxia training and acetazolamide on hypoxia induced hematological and physiological changes

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