Welding costs associated with the laying of pipes for deepwater oil and gas extraction can be reduced using high interpass temperatures (ITs). However, a high IT can decrease the mechanical properties of the heat-affected zone (HAZ) of welded joints. With the use of high strength-toughness stees, this decrease may be an acceptable trade-off. Therefore, it is necessary to evaluate the influence of high ITs on the HAZ. The influence of the IT on the coarse grain HAZ (CGHAZ) and intercritically reheated coarse-grain HAZ (ICCGHAZ) of an API 5L X70 pipe joint welded by gas metal arc welding was investigated. The welding was numerically simulated using finite element method software. The microstructure of the HAZ was predicted using thermodynamic simulation software. The CGHAZ and ICCGHAZ were also physically simulated and evaluated via optical microscopy and scanning electron microscopy, dilatometry, and Vickers microhardness and Charpy V-notch (CVN) impact tests. The increase in IT led to a decrease in CGHAZ microhardness, but did not affect the ICCGHAZ. The CVN energies obtained for all ITs (CGHAZ and ICCGHAZ) were higher than that set by the DNVGL-ST-F101 standard (50 J). These results show that increasing the IT is an interesting and effective method to reduce welding costs. In addition, thermodynamic simulation proved to be a valid method for predicting the phases in the HAZ of API 5L X70 pipe welded joints.