Effect of Intestinal Pronase Administration on Plasminogen Activator in Intestinal Mucosa

Abstract

Intestinally administered pronase resulted in a decrease in plasminogen activator activity of lysosomal and microsomal fractions in canine intestinal mucosa. Plasminogen activator was released more rapidly from the lysosomal fraction obtained from the pronase-treated intestine than from the control. Pronase inhibitor in the plasma decreased gradually reaching the highest level in 24 h after pronase administration.