Effect of intra‐abdominal hypertension on plasma exogenous creatinine clearance in conscious and anesthetized dogs

Abstract

Objective To evaluate the effect of intra‐abdominal pressure (IAP) on plasma exogenous creatinine clearance in both conscious and anesthetized dog models using a balloon technique to generate intra‐abdominal hypertension. Design Prospective, cross‐over, experimental study. Setting University‐based small animal research facility. Animals Six healthy male Beagle dogs. Interventions A balloon device comprising a Foley urinary catheter and latex balloon was placed in the intra‐abdominal cavity. Plasma exogenous creatinine clearance was compared after intravenous administration of exogenous creatinine solution at 80 mg/kg under 4 different treatment conditions as follows: control and IAP levels of 25 mm Hg in conscious dogs and control and IAP levels of 25 mm Hg in anesthetized dogs (CC, C25, AC, and A25, respectively). Samples were obtained before (T0) and 10, 20, 30, 60, 90, 120, 240, 360, 480, and 600 min after administration of creatinine in all treatment groups. Measurements and main results There were no significant differences in plasma creatinine concentration for CC, AC, and C25 during the treatment period. However, in the A25 treatment condition, the plasma creatinine concentration increased significantly at 10, 20, 30, 60, 90, and 120 min after administration of creatinine (P < 0.05). Plasma creatinine clearances were 5.0 ± 0.5, 4.7 ± 1.2, 5.5 ± 0.9, and 2.5 ± 0.5 mL/kg/min for 600 min (CC, AC, C25, and A25, respectively). In the A25 treatment condition, the plasma exogenous creatinine clearance decreased significantly to 50%, 47%, and 55% of that under control conditions (CC, AC, and C25, respectively). After decompression of the abdomen, plasma creatinine concentrations declined rapidly and returned to basal concentrations. Conclusions Intra‐abdominal hypertension under general anesthesia could cause renal hypoperfusion. Timely decompression may improve the outcome of acutely increased IAP when surgery and/or general anesthesia is required in canine patients.

Management of Postoperative Intra-Abdominal Hypertension in a Dog Undergoing Cervical Disc Surgery

“…Every hour, respiratory rate, heart rate, arterial pressure and IAP was measured (Table 1). Intravesicular pressure was used to measure IAPs in this dog (8,15), IAP and abdominal perfusion pressure (APP), which can be calculated as mean arterial pressure minus IAP, and the results are summarized in Table 1. During the postoperative monitoring period, IAP was normal and within the reference range one hour after surgery (0-7.4 mmHg) (Fig.…”

Clinical Phenotypes of Heart Failure With Preserved Ejection Fraction to Select Preclinical Animal Models

“…73,74 Creatinine clearance in healthy large animals is relative to their age and size, with a clearance of AE100 mL/min in AE60 kg pigs, and AE50 mL/min in AE10 kg dogs. 75,76 PHENOGROUP CARDIOMETABOLIC SYNDROME.…”

Effect of intra‐abdominal hypertension on the intraocular pressure of the conscious dogs

“…A previous study has demonstrated the successful increase and maintenance of IAP by air insufflation using a balloon device without general anaesthesia in a conscious IAH dog model (Jang et al., 2018, 2019). This conscious IAH dog model may be helpful for predicting changes in IOP in conscious patients because anaesthetic agents, laparoscopic surgery and posture variation can affect IOP (Grosso et al., 2013; Lentschener et al., 1996; Mowafi et al., 2003).…”