Effect of intra-abdominal instillation of lidocaine during minor laparoscopic procedures

El-Sherbiny, Walid; Saber, Walid; Askalany, Ahmed N.; Eldaly, Ashraf; Sleem, Ahmed A. Abde-aziz

doi:10.1016/j.ijgo.2009.04.016

Cited by 36 publications

(16 citation statements)

References 19 publications

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“…Although primary analysis showed a slightly steeper decreasing trend for the control group, it disappeared in multivariate longitudinal analysis while controlling for the analgesic use. This pattern of lidocaine is in line with the expected effects of lidocaine to appear at earlier hours and mainly on visceral pain (9,11,15,16). It has been shown that the effect may last even up to 3 days (15).…”

Section: Discussionsupporting

confidence: 82%

The Effect of Intravenous Infusion of Lidocaine to Control Postoperative Pain After Gynecologic Laparoscopic Surgery: A Randomized Double-Blind Placebo-Controlled Clinical Trial

Moslemi

Rasooli

Dehdilani

et al. 2017

Iran Red Crescent Med J

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Background: Pain after laparoscopy may still be moderate to severe due to stretching of intraabdominal cavity and peritoneal inflammation. Systemic lidocaine with anti-inflammatory properties may reduce this pain. Objectives: The aim of this study was to evaluate the effect of perioperative intravenous infusion of lidocaine on postoperative pain relief after gynecologic laparoscopic procedure. Methods: A double-blind randomized clinical trial study was conducted in Iran, during years 2014 and 2015. A sample of 60 females with American anesthesiology association (ASA) physical class I or II, who were scheduled for gynecologic laparoscopy were selected through consecutive sampling and were randomly assigned to receive either intravenous lidocaine or normal saline, as placebo, prior to induction of anesthesia and until the end of surgery. Severity of postoperative pain was evaluated starting at the recovery unit until 24 hours postoperatively for a total of 8 times using the visual analogue scale (VAS) scoring system. Time to first analgesic request, total analgesic dose used in the first 24 hours, and any probable postoperative complications were recorded. Risk ratio (RR) and number needed to treat (NNT) were used to analyze the data along with generalized linear model for multivariate analysis of repeated measurements over time. Results: The VAS at recovery was lower at recovery with a mean score of 2.8 in the lidocaine group versus 3.9 in the control group (P = 0.02). Results of generalized linear modelling revealed that pain intensity decreased over time in both groups (P = 0.02), and the groups had different trend slopes in pain intensity over repeated measurements at various time points up to 24 hours after laparoscopy, while controlling for the baseline VAS at recovery and ASA PS (P = 0.016). However, when controlling for use of painkillers, the trends were not found to be different. Patients in the lidocaine group were 3.8 times more likely not to need postoperative analgesic (95% CI: 1.4 to 9.9). Mean total analgesic dose was 1.3 mg in the lidocaine group versus 38.2 mg in the control group differing significantly between the 2 groups (P < 0.01). Use of lidocaine was associated with lower postoperative nausea and agitation. Conclusions: Systemic perioperative lidocaine could improve the pain pattern and severity as well as nausea and agitation after gynecologic laparoscopy. Although no major side effects were detected in this study, the benefits of the intervention should be weighed against its safety.

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Section: Discussionsupporting

confidence: 82%

The Effect of Intravenous Infusion of Lidocaine to Control Postoperative Pain After Gynecologic Laparoscopic Surgery: A Randomized Double-Blind Placebo-Controlled Clinical Trial

Moslemi

Rasooli

Dehdilani

et al. 2017

Iran Red Crescent Med J

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“…Our data support these studies and confirmed the limited duration of the local anesthetic effect with decreased narcotic use and pain scores on the day of surgery and the first postoperative day but no differences on the second postoperative day. Most previous studies included only minor gynecologic procedures such as tubal ligations, adhesiolysis, and adnexal procedures [19][20][21][22][23][24][25][26]. The results of our study as well as a study by Cruz et al [16] demonstrated that the superior pain control achieved with intraperitoneal administration of local anesthetic extends to patients undergoing minimally invasive hysterectomies and cancer staging procedures.…”

Section: Discussionsupporting

confidence: 63%

Effect of intraperitoneal bupivacaine on post-operative pain in the gynecologic oncology patient

Rivard¹,

Teoh²

2014

Gynecologic Oncology

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“…Long-acting local anesthetics have been shown to be efficient for postoperative pain relief in different types of laparoscopic procedures such as cholecystectomy [9] and appendectomy [10]. There are several studies showing conflicting results on the effect of LA instillation following gynecological laparoscopic procedures [10][11][12][13][14][15][16]. Timing of administration is of importance.…”

Section: Discussionmentioning

confidence: 99%

Pain reduction by continuous intraperitoneal nebulization of ropivacaine during gynecological laparoscopic surgery

et al. 2012

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The objective of this study was to examine the analgesic effect of intraperitoneal nebulization of ropivacaine during gynecological laparoscopic procedures for patients anesthetized with an ultrashort-acting opiate. The study was a double-blinded placebo-controlled randomized trial (Canadian Task Force classification I) and involved 40 patients (20 patients in each arm) undergoing elective gynecological same-day outpatient laparoscopic surgery including unilateral/bilateral salpingo-oophorectomy or unilateral/ bilateral ovarian cystectomy at the University Hospital Ambulatory Gynecological Endoscopic Unit. The study group received 10 ml of 1 % ropivacaine, and the control group received 10 ml of sterile water by intraperitoneal nebulization. Vital signs were recorded and summarized. Postoperatively, patients were followed up for 24 h including visual analogue scale (VAS) scores and analgesic usage. Results showed no significant differences between the two groups in terms of patient characteristics and surgical data. There were no significant differences between the groups in postoperative VAS scores at rest at the different time intervals. VAS scores during strain showed significantly decreased pain at the postoperative 2-h interval (p<0.05). Postoperative opiate and nonopiate analgesia consumption was similar for both groups. Patients in the study groups required more antiemetic agents compared to the control group patients (p<0.05). There were no reported side effects related to ropivacaine. Intraperitoneal nebulization of 100 mg of ropivacaine during gynecological laparoscopy under general anesthesia with an ultrashort-acting opiate does not reduce postoperative pain and it does not reduce postoperative opiate and nonopiate analgesia consumption.

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Effect of intra-abdominal instillation of lidocaine during minor laparoscopic procedures

Abstract: Intraperitoneal instillation of lidocaine was effective in reducing postoperative pain after minor gynecological laparoscopic procedures.

Cited by 36 publications

References 19 publications

The Effect of Intravenous Infusion of Lidocaine to Control Postoperative Pain After Gynecologic Laparoscopic Surgery: A Randomized Double-Blind Placebo-Controlled Clinical Trial

The Effect of Intravenous Infusion of Lidocaine to Control Postoperative Pain After Gynecologic Laparoscopic Surgery: A Randomized Double-Blind Placebo-Controlled Clinical Trial

Effect of intraperitoneal bupivacaine on post-operative pain in the gynecologic oncology patient

Pain reduction by continuous intraperitoneal nebulization of ropivacaine during gynecological laparoscopic surgery

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