Effect of Intraarticular Osmic Acid on Synovial Membrane Volume and Inflammation, Determined by Magnetic Resonance Imaging

Østergaard, Mikkel; Stoltenberg, Michael; Gideon, Peter; Wieslander, S.; Sonne‐Holm, Stig; Kryger, P; Sonne, M

doi:10.3109/03009749509095146

Cited by 36 publications

(16 citation statements)

References 28 publications

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“…The study of the joints using MRI-Gd permits the observation and measurement of the inflamed SM [1][2][3][4][5][6][7]. r et al [8] used MRI-Gd to study the effect of an intra-articular injection of osmic acid. MRI-Gd was carried out before, and 1 month after, the injection of osmic acid in 18 knees with RA.…”

Section: Discussionmentioning

confidence: 99%

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Efficacy of radiosynovectomy of the knee in rheumatoid arthritis: Evaluation with magnetic resonance imaging

et al. 1998

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The intra-articular injection of a radiopharmaceutical agent (radiosynovectomy) produces a reduction of the synovial inflammatory process. The inflammed synovial membrane can be identified with magnetic resonance imaging after the intravenous administration of gadolinium (MRI-Gd). A 6-month prospective study was carried out in 10 patients with rheumatoid arthritis after radiosynovectomy of the knee. The efficacy was evaluated with clinical parameters and MRI-Gd. A progressive amelioration of synovial effusion, pain, articular range of mobility, total leucocytes count in synovial fluid and synovial membrane thickness through MRI-Gd was observed. The global efficacy was considered to be good in six patients, fair in three and bad in one. The study shows for the first time that MRI-Gd allows the evaluation of the response of the synovial membrane to radiosynovectomy.

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Section: Discussionmentioning

confidence: 99%

“…Recently, the effect of intra-articular osmic acid [8] and corticosteroids [9][10][11] on the SM has been studied using MRI-Gd. Radiosynovectomy (RS) is a procedure that reduces the inflammatory process within the SM using an intra-articular injection of a beta-emitting radiopharmaceutical [12].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of radiosynovectomy of the knee in rheumatoid arthritis: Evaluation with magnetic resonance imaging

et al. 1998

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“…Quantitative ''volume measuring'' [45][46][47][48][49][50][51][52][53][54][55][56][57][58] is favored by the highest accuracy and may be considered a golden standard, but it is very time-consuming.…”

Section: Mri Measures Of Synovitismentioning

confidence: 99%

“…20,38,47,48,[50][51][52]76,77 The quantitative measures as well as semiquantitative scores of synovitis in knees, 38,50,77 wrists, 20,76 and MCP joints 22 decrease when glucocorticoids or disease-modifying drugs are administered. The repeatability index (2 standard deviations of the differences between repeated measurements) is useful to determine the smallest difference between two values of a measure that can be reliably detected (smallest detectable difference, SDD).…”

Section: Construct Validitymentioning

confidence: 99%

Magnetic Resonance Imaging of the Synovium in Rheumatoid Arthritis

Østergaard

Ejbjerg

2004

Semin Musculoskelet Radiol

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Early diagnosis, followed by early initiation and optimal adjustments of aggressive therapies, are acknowledged as essential to optimize long-term clinical and radiological outcome in rheumatoid arthritis (RA). This requires sensitive methods for detection and monitoring of the primary feature of RA--the synovitis. In comparison with conventional methods, magnetic resonance imaging (MRI) offers assessment of the rheumatoid synovium with improved sensitivity to early pathology and to change. Various aspects such as volume, vascularity, and edema can be assessed by different metrological approaches. MRI findings are of prognostic value to the long-term radiological outcome. This article reviews current knowledge on MRI for assessment of the synovium in RA, focusing on the validity of MRI measures of synovitis. Future perspectives and suggested research priorities are described. The rationale is provided for MRI becoming the new gold standard for assessment of RA joints and for MRI assessments of synovitis being reliable and valid measures of rheumatoid disease activity.

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“…Moreover, quantitative analysis of pannus by MRI seems to be a sensitive method in the evaluation of response to therapy [1, 2, 7, 8,9].…”

Section: Introductionmentioning

confidence: 99%

MR imaging assessment of clinical problems in rheumatoid arthritis

Narváez

Roca

et al. 2002

Eur Radiol

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Although MR imaging has been increasingly recognized as a useful tool in the diagnosis of early rheumatoid arthritis (RA) and in the assessment of disease activity, these applications have not yet been usually included in the routine management of this condition. Our goal is to review the current role of MRI in the everyday clinical management of patients with RA. The usefulness of MRI in the evaluation of articular and para-articular changes in specific locations, mainly the craniocervical region and the temporomandibular joint, are reviewed. Clinical problems derived from local extra-articular involvement, such as tenosynovitis, "rice-bodies" bursitis, and Baker's cyst rupture, are also described. Finally, we also review the value of MRI in evaluation of some complications of RA such as tendinous rupture, osteonecrosis, stress fracture, and septic arthritis/osteomyelitis.

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Effect of Intraarticular Osmic Acid on Synovial Membrane Volume and Inflammation, Determined by Magnetic Resonance Imaging

Cited by 36 publications

References 28 publications

Efficacy of radiosynovectomy of the knee in rheumatoid arthritis: Evaluation with magnetic resonance imaging

Efficacy of radiosynovectomy of the knee in rheumatoid arthritis: Evaluation with magnetic resonance imaging

Magnetic Resonance Imaging of the Synovium in Rheumatoid Arthritis

MR imaging assessment of clinical problems in rheumatoid arthritis

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