Effect of intracanal cryotherapy application on postoperative endodontic pain: a systematic review and metaanalysis

Is Intracanal Cryotherapy Effective in Reducing Postoperative Endodontic Pain? An Updated Systematic Review and Meta-Analysis of Randomized Clinical Trials

“…These results were consistent with previous systematic reviews [59,60]. However, Monteiro et al in their systematic review and meta-analysis showed that pain was only minimized 6 and 24 h postoperatively [61]. After seven days, there was a reduction in the postoperative pain scores in the intracanal cryotherapy group (experimental group) compared with the room temperature group (control group) but this reduction could not be proven statistically due to inestimable MD and CI values.…”

“…These results were in contrast to a previous systematic review that also evaluated the efficacy of intracanal cold therapy for the management of postoperative endodontic pain and the certainty of evidence was judged as moderate [60]. Another systematic review evaluated the same topic but the certainty of evidence was considered very low due to serious concerns with the risk of bias and inconsistency as well as very serious concerns with the imprecision [61].…”

Effect of intracanal cryotherapy on the inflammatory cytokine, proteolytic enzyme levels and post‐operative pain in teeth with asymptomatic apical periodontitis: A randomized clinical trial

“…Few studies evaluated the effect of cryotherapy on limited biomarkers with different clinical trials, and several studies showed that the cryotherapy decreased post‐operative endodontic pain in different clinical scenarios (Emad et al, 2021; Mourad et al, 2021). However, the recent systematic reviews and meta‐analyses have emphasized the requirement of standardized randomized clinical trials adhering to more clear and strict criteria, randomisation and blinding to clearly define the efficacy of cryotherapy in the management of post‐operative pain (Almohaimede & Al‐Madi, 2021; Gupta et al, 2021; Monteiro et al, 2021). In this randomized controlled trial, intracanal cryotherapy significantly decreased interappointment pain scores and caused different concentration of tested biomarkers.…”

“…Intracanal cryotherapy emerged as a simple, economical and non‐toxic pain control technique that aims to eliminate the side effects of acetaminophen and NSAIDs by reducing their intake after root canal treatment (Aminoshariae & Khan, 2015; Monteiro et al, 2021). This technique can be easily integrated into the endodontic treatment routine and represents an alternative for post‐operative pain control, especially in patients with drug allergies, geriatric patients or pregnant women who avoid the use of painkillers (Emad et al, 2021).…”

“…However, recent systematic reviews and meta‐analyses emphasized further randomized controlled clinical investigations are required to evaluate the efficacy of the technique (Almohaimede & Al‐Madi, 2021; Gupta et al, 2021; Monteiro et al, 2021). This randomized controlled study aimed to investigate the effect of intracanal cryotherapy on the IL‐1β, IL‐2, IL‐6, IL‐8, PGE 2 , TNF‐α and MMP‐8 levels in the periapical exudate of mandibular pre‐molar teeth with asymptomatic apical periodontitis, to compare cryotherapy and control groups in terms of interappointment and post‐operative pain level and analgesic intake, and investigate a possible the correlation between biomarker levels and interappointment endodontic pain.…”