Effect of intracerebroventricular administration of opioid peptides on basal serum adrenaline levels in conscious rats.

Nakamura, Mikio; Kamata, Kunie; Inoue, Hakubun; Inaba, Masaaki

doi:10.1254/jjp.47.151

Cited by 6 publications

(2 citation statements)

References 15 publications

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“…37 Moreover, naloxone may inhibit the secretion of epinephrine by the adrenal medulla evoked by central opioid receptor stimulation. 38 Since naloxone in the low doses used in this study is primarily a fi opioid receptor antagonist, 39 the results suggest that the pressor response to air stress is dependent on the n opioid receptor. Furthermore, studies with naltrexone methylbromide indicate a central nervous system location, which is supported by the finding that only intracerebroventricular administration of naltrexone methylbromide was effective in preventing the increase in arterial pressure to air stress.…”

Section: Discussionmentioning

confidence: 83%

Opioids in the systemic hemodynamic and renal responses to stress in spontaneously hypertensive rats.

1989

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Endogenous opioid peptides have been implicated in the regulation of cardiovascular and renal function. We tested this hypothesis by examining whether the opioid antagonist naloxone alters the cardiovascular or renal responses produced by environmental stress (air stress) in conscious spontaneously hypertensive rats (SHR). Before naloxone administration, air stress produced significant increases in heart rate, mean arterial pressure, and renal sympathetic nerve activity, and it caused a decrease in urinary sodium excretion. After intravenous and intracerebroventricular administration of naloxone, the air stress-induced pressor and antinatriuretic responses were inhibited. Subsequent studies with a different opioid antagonist, the quaternary compound naltrexone methylbromide, also showed inhibition of the air stress-induced pressor and antinatriuretic responses and demonstrated opioid receptor specificity of this inhibition. Furthermore, since only intracerebroventricular and not intravenous administration of naltrexone methylbromide inhibited the pressor and antinatriuretic responses to air stress, a central nervous system site of action was established. The opioid antagonists caused inhibition of the pressor and antinatriuretic responses to air stress without affecting the air stress-induced increase in renal sympathetic nerve activity. Our investigations indicate that central endogenous opioid peptides contribute to the pressor and antinatriuretic responses that occur in conscious SHR during acute environmental stress. {Hypertension 1989; 13:808-816)

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Section: Discussionmentioning

confidence: 83%

Opioids in the systemic hemodynamic and renal responses to stress in spontaneously hypertensive rats.

1989

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“…This effect was inhibited by naloxone (i.c.v.) (1). In the present paper, we report the effects of several opioid peptides (i.c.v.)…”

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confidence: 94%

Effects of opioid peptides administered in conscious rats on the changes in blood adrenaline leves caused by immobilization stress.

et al. 1989

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Abstract-Effectsof several opioid peptides administered in the lateral cerebro ventricle on the changes in blood adrenaline (AD) levels were examined at 10 , 20 and 30 min after the start of immobilization in conscious rats. 8-Endorphin, (D Ala2) -Met-enkephalinamide, morphiceptin and (D-Ala2, D-Leu5)-enkephalinamide produced significantly lower elevations of AD than the control, and the effect was enhanced by naloxone. The effect of dynorphin, however, was almost the same as that of the control.

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The influence of α-fluoromethylhistidine and histamine receptor antagonists on the β-endorphin-induced corticosterone response

Turoń¹,

Tytoń²,

Bugajski³

1991

Life Sciences

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Effect of intracerebroventricular administration of opioid peptides on basal serum adrenaline levels in conscious rats.

Cited by 6 publications

References 15 publications

Opioids in the systemic hemodynamic and renal responses to stress in spontaneously hypertensive rats.

Opioids in the systemic hemodynamic and renal responses to stress in spontaneously hypertensive rats.

Effects of opioid peptides administered in conscious rats on the changes in blood adrenaline leves caused by immobilization stress.

The influence of α-fluoromethylhistidine and histamine receptor antagonists on the β-endorphin-induced corticosterone response

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