1991
DOI: 10.1056/nejm199103073241002
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Effect of Intracoronary Serotonin on Coronary Vessels in Patients with Stable Angina and Patients with Variant Angina

Abstract: Patients with stable coronary disease do not have the normal vasodilator response to intracoronary serotonin, but rather have progressive constriction, which is particularly intense in small distal and collateral vessels. Patients with variant angina have occlusive coronary-artery spasm at a dose that dilates normal vessels and causes only slight constriction in vessels from patients with stable angina. These findings suggest that serotonin, released after the intracoronary activation of platelets, may contrib… Show more

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Cited by 343 publications
(124 citation statements)
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“…Similar findings have also been reported in the rabbit isolated femoral artery (MacLennan & Martin, 1992) and dog coronary artery (Mullane et al, 1982). Whilst this potentiation effect of U46619 is not specific for 5-HT agonists (Cocks et al, 1993), such findings may have important clinical implications as both thromboxane A2 and 5-HT are released locally from aggregating platelets and amplification of the constrictor response to 5-HT receptor agonists, could lead to coronary vasospasm in arteries hyperreactive to 5-HT (Golino et al, 1989;Zeiher et al, 1991;McFadden et al, 1991;Willett et al, 1992).…”
Section: Introductionsupporting
confidence: 63%
“…Similar findings have also been reported in the rabbit isolated femoral artery (MacLennan & Martin, 1992) and dog coronary artery (Mullane et al, 1982). Whilst this potentiation effect of U46619 is not specific for 5-HT agonists (Cocks et al, 1993), such findings may have important clinical implications as both thromboxane A2 and 5-HT are released locally from aggregating platelets and amplification of the constrictor response to 5-HT receptor agonists, could lead to coronary vasospasm in arteries hyperreactive to 5-HT (Golino et al, 1989;Zeiher et al, 1991;McFadden et al, 1991;Willett et al, 1992).…”
Section: Introductionsupporting
confidence: 63%
“…Persistent thrombus might predispose to recurrent ischemia.10"' Abnormal vasoconstriction is also implicated in the pathogenesis of the acute coronary syndromes.13-'8 The risk of recurrence in these patients could be related to abnormal vasoreactivity of the culprit lesion due to powerful platelet/thrombin-mediated stimuli.12 "19-22 Substances such as serotonin, thromboxane A2, and endothelin released from an unstable coronary lesion might also influence the tonus and reactivity of the vasculature further downstream. 23 (Fig 1). The luminal diameters of the culprit lesion and of the stable angina control lesion for each of the patients with each of the interventions appear in (Fig 2).…”
mentioning
confidence: 99%
“…The coronary smooth muscle of patients with vasospastic angina is hypercontractile to various stimuli such as histamine, 20 ergonovine, 7 serotonin, 8 etc. In addition to an altered contractile response of coronary smooth muscle, impaired endothelial function, especially NO function, is associated with coronary vasospasm.…”
Section: Discussionmentioning
confidence: 99%