Effect of intracoronary tirofiban on platelet alpha-granule membrane protein and myocardial perfusion level during emergency percutaneous coronary intervention

Xu, Hao; Liu, C.M.; Zhang, W.W.

doi:10.4238/2014.november.14.3

Cited by 2 publications

(1 citation statement)

References 22 publications

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“…After the 6‐month HD treatment, the total amount levels of CD62P and P10 expressions were found to be significantly lower in the effective group compared to the ineffective group, thus, indicating CD62P and P10 could be used in the prediction of HD efficacy in treating ESRD. CD62P, also named P‐selectin or granule membrane protein 140 (GMP‐140), is usually distributed in the alpha‐granules of resting platelets and after the platelet activation it gets transferred to the cell surface . The interaction of CD62P with P‐selectin glycoprotein ligand‐1 (PSGL‐1) on the surface of the activated endothelial cells mediates tethering and rolling of leukocytes, which is the first step in the process of leukocyte extravasation and migration towards the sites of inflammation .…”

Section: Discussionmentioning

confidence: 99%

CD62P and P10 as predictive markers for assessing the efficacy of hemodialysis in treating end‐stage renal disease

Wang

et al. 2018

Clinical Laboratory Analysis

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Background CD62P is a platelet α‐granule membrane protein, and P10 is a platelet membrane glycoprotein thrombospondin. To better understand the effects of hemodialysis (HD), we have conducted this study to investigate CD62P and P10 in assessing the efficacy of HD in treating patients with end‐stage renal disease (ESRD). Methods The case group consisted of 111 patients suffering ESRD treated with regular HD and the control group enrolled 117 healthy subjects. Before and after HD treatment, a series of parameters were observed, based on which, CD62P and P10 levels were detected in the patients in two groups before and after HD therapy. The correlation analysis analyzed the correlations of CD62P and P10 markers with serum creatinine (Scr), blood urea nitrogen (BUN), and subjective score; and logistic regression analysis was performed to reveal factors affecting the efficacy of HD. Results BUN, Scr, serum phosphorus, intact parathyroid hormone (iPTH), fibrinogen, and β2‐microglobulin (β2‐MG) decreased while hemoglobin, albumin, and activated partial thromboplastin time increased in the patients suffering ESRD; patients presented with improvements in subjective symptoms and an increase in dry weight. CD62P and P10 levels were lower in post‐treatment patients. CD62P and P10 positively correlated with Scr, BUN and subjective score; post‐treatment CD62P and P10 levels, BUN, hemoglobin, albumin, triglyceride, iPTH, β2‐MG, and fibrinogen were correlated with the efficacy of HD. Conclusion CD62P and P10 might be correlated to the efficacy of HD in treating ESRD, in turn providing predictive markers for assessing the ability of HD in treating ESRD.

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Section: Discussionmentioning

confidence: 99%