Effect of intracranial bleeds on the health and quality of life of boys with hemophilia

Revel‐Vilk, Shoshana; Golomb, Meredith R.; Achonu, Camille; Stain, Ann Marie; Armstrong, Derek; Barnes, Marcia A.; Anderson, Peter; Logan, William J.; Sung, Lillian; McNeely, Michael D.; Blanchette, Victor S.; Feldman, Brian M.

doi:10.1016/j.jpeds.2003.12.016

Cited by 44 publications

(58 citation statements)

References 23 publications

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“…Several reports have suggested an increased incidence of clinically significant intracranial hemorrhage and worse outcomes for patients with hemophilia and inhibitors. [24][25][26][27][28][29] Our study was not powered to detect the benefit of prophylaxis for low-incidence, high-morbidity bleeding events such as intracranial hemorrhage. However, it is reasonable to assume that patients who have a good response to prophylaxis are also likely to have a reduced risk of life-threatening bleeding.…”

Section: Discussionmentioning

confidence: 99%

Anti-Inhibitor Coagulant Complex Prophylaxis in Hemophilia with Inhibitors

et al. 2011

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Section: Discussionmentioning

confidence: 99%

Anti-Inhibitor Coagulant Complex Prophylaxis in Hemophilia with Inhibitors

et al. 2011

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Section: Special Populationsmentioning

confidence: 99%

“…The prevalence of intracranial (epidural, subdural, and parenchymal) hemorrhage in hemophiliac children has been reported to be between 2.9% and 12% [28][29][30]. ICH is most common in young boys, with a median age at onset of 5.9 months to 2 years [28,29]. Trauma is the most important risk factor for ICH in children with hemophilia [28]; other risk factors include factor VIII or IX inhibitors, increased use of factor prophylaxis, and reduced annual household income [29].…”

Section: Special Populationsmentioning

confidence: 99%

“…ICH is most common in young boys, with a median age at onset of 5.9 months to 2 years [28,29]. Trauma is the most important risk factor for ICH in children with hemophilia [28]; other risk factors include factor VIII or IX inhibitors, increased use of factor prophylaxis, and reduced annual household income [29]. Post-traumatic ICH in hemophilia can be indolent, with a symptom-free interval of up to 10 days [31].…”

Section: Special Populationsmentioning

confidence: 99%

“…Data in young children are sparse; however, in a series of 11 full-term neonates with IPH only 4 of 11 (36%) had a normal neurologic examination at a mean follow up of 4.5 years [17]. Children with hemophilia who suffer a brain hemorrhage often do so at the time of birth or during the first two years of life [28,29]; neonates have the worst neurologic outcomes [28]. One study of 34 children specifically addressed features that predict poor neurologic outcome; Meyer-Heim et al [16] found that infratentorial location, Glasgow Coma Score (GCS) ≥ 7 at admission, aneurysm, age <3 years at the time of HS, and underlying hematological disorder all were predictors of more severe outcome.…”

Section: Neurologic Outcome and Hs Recurrencementioning

confidence: 99%

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Hemorrhagic Stroke in Children

Jordan

Hillis

2007

Pediatric Neurology

116

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Hemorrhagic stroke accounts for approximately half of stroke in childhood. Unlike arterial ischemic stroke, there are no consensus guidelines to assist in the evaluation and treatment of these children. We review the literature on the evaluation, treatment, etiology and neurologic outcome of hemorrhagic stroke in children. Important differences between pediatric and adult hemorrhage are highlighted, as treatment guidelines for adults may not be applicable in all cases. Needed future research and potential therapies are also discussed.

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Psycho‐social determinants of quality of life in children and adolescents with haemophilia—a cross‐cultural approach

Bullinger

Mackensen

2008

Clin Psychology and Psychoth

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Quality of life (QoL) of children with chronic conditions has received increasing attention in recent years. While frequent paediatric health conditions and life-threatening conditions are in the foreground, QoL of children with rare diseases such as haemophilia is scarce. While haemophilia-specific instruments to assess QoL in children have been developed, cross-cultural comparison of QoL and its determinants has not been addressed so far. QoL and potential psychosocial determinants such as coping were assessed in 298 paediatric haemophilia patients from six European countries demonstrating significant differences in QoL between countries. Results indicated that psychosocial predictors varied across countries, although life satisfaction and social support explained the highest proportion of variance and, moreover, superseded clinical characteristics. These findings suggest that intervention programmes should be geared towards enhancing psychosocial resources in children and adolescents with haemophilia.

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Effect of intracranial bleeds on the health and quality of life of boys with hemophilia

Cited by 44 publications

References 23 publications

Anti-Inhibitor Coagulant Complex Prophylaxis in Hemophilia with Inhibitors

Anti-Inhibitor Coagulant Complex Prophylaxis in Hemophilia with Inhibitors

Hemorrhagic Stroke in Children

Psycho‐social determinants of quality of life in children and adolescents with haemophilia—a cross‐cultural approach

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