Effect of intraluminal thrombus on abdominal aortic aneurysm wall stress

Mower, William R.; Quinones, William; Gambhir, Sanjiv S.

doi:10.1016/s0741-5214(97)70058-2

Cited by 181 publications

(159 citation statements)

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“…The AAA arises in the infrarenal aorta with a diameter greater than 3 cm and can be up to 9 cm in length [1,2]. Most of the studies on aneurysms have focused on already existing realistic or idealized aneurysms [33][34][35][36][37][38][39][40][41][42][43] with the aim of defining a relevant rupture criterion [4,7,10,19,20,24]. The ratio of the vessel stress to vessel strength is regarded as an alternative tool to conventional diameter criteria, which may be insufficient in small aneurysms.…”

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confidence: 99%

“…The ratio of the vessel stress to vessel strength is regarded as an alternative tool to conventional diameter criteria, which may be insufficient in small aneurysms. In computational simulations, vessel stress is calculated as a function of the vessel diameter [7,34], wall thickness [36,37], asymmetry [14,18,34,36], tortuosity [21], material property [17,24,29,38], calcification [15,22], intraluminal thrombus (ILT) [5,15,16,33], and blood flow [4, 9, 13, 14, 17, 20, 25, 26, 28-30, 32, 35-41]. Blood vessel strength is measured by ex vivo studies [11,12,23,31,44] or estimated by effective features such as ILT existence, sex, and genetic vulnerability [10].…”

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confidence: 99%

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Investigation of material modeling in fluid–structure interaction analysis of an idealized three-layered abdominal aorta: aneurysm initiation and fully developed aneurysms

Şimşek

Kwon

2015

J Biol Phys

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Different material models for an idealized three-layered abdominal aorta are compared using computational techniques to study aneurysm initiation and fully developed aneurysms. The computational model includes fluid-structure interaction (FSI) between the blood vessel and the blood. In order to model aneurysm initiation, the medial region was degenerated to mimic the medial loss occurring in the inception of an aneurysm. Various cases are considered in order to understand their effects on the initiation of an abdominal aortic aneurysm. The layers of the blood vessel were modeled using either linear elastic materials or Mooney-Rivlin (otherwise known as hyperelastic) type materials. The degenerated medial region was also modeled in either linear elastic or hyperelastic-type materials and assumed to be in the shape of an arc with a thin width or a circular ring with different widths. The blood viscosity effect was also considered in the initiation mechanism. In addition, dynamic analysis of the blood vessel was performed without interaction with the blood flow by applying time-dependent pressure inside the lumen in a three-layered abdominal aorta. The stresses, strains, and displacements were compared for a healthy aorta, an initiated aneurysm and a fully developed aneurysm. The study shows that the material modeling of the vessel has a sizable effect on aneurysm initiation and fully developed aneurysms. Different material modeling of degeneration regions also affects the stressstrain response of aneurysm initiation. Additionally, the structural analysis without considering FSI (called noFSI) overestimates the peak von Mises stress by 52% at the interfaces of the layers.

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confidence: 99%

Investigation of material modeling in fluid–structure interaction analysis of an idealized three-layered abdominal aorta: aneurysm initiation and fully developed aneurysms

Şimşek

Kwon

2015

J Biol Phys

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“…Some researchers claim that ILT lowers the rupture risk. This purely mechanical standpoint is derived from computer analysis and assumes that additional layer in AAA has protective effect of reducing the wall stress [19][20][21][22].…”

Section: Presence Of Intraluminal Thrombus and Calcifications In Aaa mentioning

confidence: 99%

Biomechanical factors in Finite Element Analysis of abdominal aortic aneurysms

et al. 2017

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“…Intraluminal thrombus has been incorporated in the finite-element models in several other studies [9,21,48]. In [48] and [9] a significant influence was reported of thrombus on the outcome of the stress calculations.…”

Section: Wall-stress Modelingmentioning

confidence: 99%

Towards patient-specific risk assessment of abdominal aortic aneurysm

Breeuwer

Putter

Kose

et al. 2008

Med Biol Eng Comput

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Document VersionPublisher's PDF, also known as Version of Record (includes final page, issue and volume numbers)Please check the document version of this publication:• A submitted manuscript is the author's version of the article upon submission and before peer-review. There can be important differences between the submitted version and the official published version of record. People interested in the research are advised to contact the author for the final version of the publication, or visit the DOI to the publisher's website.• The final author version and the galley proof are versions of the publication after peer review.• The final published version features the final layout of the paper including the volume, issue and page numbers. Link to publication Citation for published version (APA):Breeuwer, M., Putter, de, S., Kose, U., Speelman, L., Visser, K., Gerritsen, F. A., ... Vosse, van de, F. N. (2008). Towards patient-specific risk assessment of abdominal aortic aneurysm. Medical and Biological Engineering and Computing, 46(11), 1085-1095. DOI: 10.1007/s11517-008-0393-0 General rightsCopyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal ? Take down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Abstract Diagnosis of vascular disease and selection and planning of therapy are to a large extent based on the geometry of the diseased vessel. Treatment of a particular vascular disease is usually considered if the geometrical parameter that characterizes the severity of the disease, e.g. % vessel narrowing, exceeds a threshold. The thresholds that are used in clinical practice are based on epidemiological knowledge, which has been obtained by clinical studies including large numbers of patients. They may apply ''on average'', but they can be sub-optimal for individual patients. To realize more patient-specific treatment decision criteria, more detailed knowledge may be required about the vascular hemodynamics, i.e. the blood flow and pressure in the diseased vessel and the biomechanical reaction of the vessel wall to this flow and pressure. Over the last decade, a substantial number of publications have appeared on hemodynamic modeling. Some studies have provided first evidence that this modeling may indeed be used to support therapeutic decisions. The goal of the research reported in this paper is to go one step further, namely to investigate the feasibilit...

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Effect of intraluminal thrombus on abdominal aortic aneurysm wall stress

Abstract: Intraluminal thrombus can significantly reduce AAA wall stress.

Cited by 181 publications

References 13 publications

Investigation of material modeling in fluid–structure interaction analysis of an idealized three-layered abdominal aorta: aneurysm initiation and fully developed aneurysms

Investigation of material modeling in fluid–structure interaction analysis of an idealized three-layered abdominal aorta: aneurysm initiation and fully developed aneurysms

Biomechanical factors in Finite Element Analysis of abdominal aortic aneurysms

Towards patient-specific risk assessment of abdominal aortic aneurysm

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