Effect of intranasal histamine challenge on Eustachian tube function

Ebert, Charles S.; Pollock, Hoke W.; Dubin, Marc G.; Scharer, Scott S; Prazma, Jiri; McQueen, Chapman T.; Pillsbury, Harold C.

doi:10.1016/s0165-5876(02)00007-1

Cited by 24 publications

(12 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is despite extensive research into animal models for eustachian tube dysfunction. 45,46,81,83,87,[96][97][98][99][100][101][102][103][104][105][106][107][108][109][110] One study demonstrated a role for the eustachian tube in tympanic membrane healing. 3 Blockage of the eustachian tube did not cause delayed closure of pars tensa perforations when the two procedures were performed at the same time.…”

Section: Discussionmentioning

confidence: 99%

Chronic tympanic membrane perforation: a better animal model is needed

Maria

Atlas

Ghassemifar

2007

Wound Repair Regeneration

View full text Add to dashboard Cite

Developments in the treatment of chronic tympanic membrane perforation have been hindered by the lack of an ideal animal model. It is not appropriate to test such treatments on acute perforations as the majority of these heal spontaneously. An ideal animal model would be one that most closely resembles the human clinical situation. It should be inexpensive, readily available, and easy to create. There have been a number of attempts to create a chronic tympanic membrane perforation model with limited success. All published attempts at chronic tympanic membrane perforations have been reviewed and the limitations of each model are discussed. A number of areas for research exist for further developing a chronic tympanic membrane perforation model. These areas include a perforation model in the presence of bacteria and eustachian tube dysfunction. Understanding the molecular and genetic mechanisms of chronic otitis media and potential treatments will also be useful.

show abstract

Section: Discussionmentioning

confidence: 99%

Chronic tympanic membrane perforation: a better animal model is needed

Maria

Atlas

Ghassemifar

2007

Wound Repair Regeneration

View full text Add to dashboard Cite

show abstract

“…This procedure has been described previously [18,28]. Briefly, while under anesthesia with a xylazine/ketamine mixture, subjects were placed in the lateral recumbent position.…”

Section: Assessment Of Eustachian Tube Functionmentioning

confidence: 99%

The role of immunomodulatory oligonucleotides in prevention of OVA-induced Eustachian tube dysfunction

Ebert¹,

Rose²,

Patel³

et al. 2006

International Journal of Pediatric Otorhinolaryngology

Self Cite

View full text Add to dashboard Cite

“…Previous studies have demonstrated increased IgE response in the Brown Norway rat in asthma, allergic rhinitis, and food allergies [39][40][41]. These studies demonstrated that CpG ODNs signifi cantly reduced the systemic and pulmonary manifestations of allergy.…”

Section: Delivery Methodsmentioning

confidence: 68%

“…Our laboratory has used multiple challenge and treatment approaches. We have investigated the use of CpG ODNs when delivered via subcutaneous injection before transtympanic allergen challenge and found no clinical evidence of middle ear effusion in treated animals compared with untreated animals [39]. Ebert et al [44] demonstrated that subcutaneous injection of CpG ODNs can prevent allergic-like infl ammation of ET after intranasal allergen exposure.…”

Section: Delivery Methodsmentioning

confidence: 99%

Immune modulatory oligonucleotides in the prevention and treatment of allergen-induced eustachian tube dysfunction in the animal model

Blanks

Ebert²

2008

Curr Allergy Asthma Rep

View full text Add to dashboard Cite

This article reviews the current literature investigating the applications and success of immune modulatory oligonucleotides as immunotherapy to treat and prevent allergen-induced eustachian tube dysfunction in animal models. Synthetic DNA-based immunotherapy agents composed of unmethylated cytosine-guanine dinucleotides (CpG ODNs) that bind to Toll-like receptors have been found to have tremendous potential as therapeutic agents and adjuvants. CpG ODNs can induce a shift in the cytokine profile and immune response that favors the T-helper type 1 pathway and suppresses the T-helper type 2 pathway. This makes CpG ODNs promising candidates for treating allergic diseases. Current CpG ODN studies have demonstrated prevention and treatment of acute allergen inflammation of the eustachian tube in an animal model of otitis media. Immune modulatory oligonucleotides in immunotherapy, administered systemically or topically, have been shown to be safe and effective in the animal model.

show abstract

Effect of intranasal histamine challenge on Eustachian tube function

Cited by 24 publications

References 18 publications

Chronic tympanic membrane perforation: a better animal model is needed

Chronic tympanic membrane perforation: a better animal model is needed

The role of immunomodulatory oligonucleotides in prevention of OVA-induced Eustachian tube dysfunction

Immune modulatory oligonucleotides in the prevention and treatment of allergen-induced eustachian tube dysfunction in the animal model

Contact Info

Product

Resources

About