Effect of intraoperative acetated Ringer’s solution with 1% glucose on glucose and protein metabolism

Yamasaki, Kentaro; Inagaki, Yoshimi; Mochida, Shinsuke; Funaki, Kazumi; Takahashi, Shunsaku; Sakamoto, Seiji

doi:10.1007/s00540-010-0926-1

Cited by 37 publications

(37 citation statements)

References 33 publications

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“…Blood β-OHB levels correlate with the amount of gluconeogenesis via lipolysis (i.e., fat catabolism). A recent clinical study (16) reported that glucose administration during surgery under sevoflurane anesthesia significantly suppresses lipolysis. Consistent with this finding, blood β-OHB levels decreased after glucose administration in group S-IVGTT in the present study.…”

Section: Discussionmentioning

confidence: 99%

Comparison of mechanisms underlying changes in glucose utilization in fasted rats anesthetized with propofol or sevoflurane: Hyperinsulinemia is exaggerated by propofol with concomitant insulin resistance induced by an acute lipid load

Kitamura

Kawamura

et al. 2014

BST

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Section: Discussionmentioning

confidence: 99%

Comparison of mechanisms underlying changes in glucose utilization in fasted rats anesthetized with propofol or sevoflurane: Hyperinsulinemia is exaggerated by propofol with concomitant insulin resistance induced by an acute lipid load

Kitamura

Kawamura

et al. 2014

BST

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“…Some previous studies have shown that the administration of glucose during surgery can inhibit starvation-induced catabolism [1][2][3][4][5][6][7] and attenuate post-operative insulin resistance [8]. Furthermore, the degree of postoperative insulin resistance was found to be an independent factor associated with the length of the postoperative hospital stay [9].…”

Section: Introductionmentioning

confidence: 82%

Administration of low dose of glucose suppresses catabolism under general anaesthesia maintained with remifentanil

Yoshimura¹,

Tomita²,

Kusama³

et al. 2017

J Anesthesiol Clin Sci

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Background: The aim of this prospective randomized controlled study was to examine the optimal rate of glucose administration for preventing catabolism under general anaesthesia maintained with remifentanil. Methods: Forty-five consecutive patients who were scheduled to undergo elective head and neck surgery were enrolled. The patients were divided into three groups and were treated with a glucose-free solution (Group G0) or a glucose solution at a rate of 0.07 g/kg/h (Group G1) or 0.14 g/kg/h (Group G2). The patients' plasma glucose, the plasma levels of ketone bodies, free fatty acids (FFA), 3-methylhistidine (3-MH), creatinine (Cr), Branched-Chain Amino Acid (BCAA), and stress hormones were measured every two hours until 6h (T6). Results:The plasma glucose levels of Group G2 were significantly higher than those of the other groups at T2, T4, and T6 (P<0.01); however, the plasma glucose levels of the three groups did not differ at POD1. Group G0 exhibited significantly higher plasma ketone body and BCAA levels (at T2, T4, and T6) and FFA levels (at T4 and T6). No significant inter-group differences in the plasma levels of 3-MH/Cr or stress hormones were observed. Conclusions: Intraoperative glucose administration at a rate of 0.07 g/kg/h under general anaesthesia inhibited catabolism without the risk of hyperglycaemia.

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“…Ketone body fractions increased significantly in both groups until end of surgery because glucose was not administered during surgery. To suppress catabolism, not only preoperative but also intraoperative glucose administration should be considered [21][22][23][24].…”

Section: Discussionmentioning

confidence: 99%

Hypoglycemia in Laparoscopic Colectomy with Remifentanil Use and Preoperative Intravenous Glucose Infusion: A Prospective, Randomized, Single-Blind, Controlled Trial

Kanamori¹,

Aihara²,

Morioka³

et al. 2016

J Anesth Clin Res

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Background: The profound effect of a minimally-invasive procedure under general anesthesia with remifentanil contributes to suppression of hyperglycemic responses, which was formerly observed as a stress response. However, intraoperative occurrence of hypoglycemia is considered more of a concern. In addition, depending on preoperative nutritional status, critical hypoglycemia may occur during surgery. There are few reports on perioperative glucose metabolism in patients not receiving glucose infusion under anesthesia with remifentanil. The preoperative fasting period is longer in Japan and preoperative carbohydrate infusion or other pretreatment is not actively performed; thus, the preoperative nutritional status is close to that of starvation. Furthermore, the regulation of glucose metabolism under intraoperative management with potent opioids, such as remifentanil, as well as the fluctuations in metabolism due to perioperative glucose infusion, is important from the viewpoint of nutritional management.

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Effect of intraoperative acetated Ringer’s solution with 1% glucose on glucose and protein metabolism

Abstract: The infusion of a small dose of glucose (1%) during minor otorhinolaryngeal, head and neck surgeries may suppress protein catabolism without hyperglycemia and hypoglycemia.

Cited by 37 publications

References 33 publications

Comparison of mechanisms underlying changes in glucose utilization in fasted rats anesthetized with propofol or sevoflurane: Hyperinsulinemia is exaggerated by propofol with concomitant insulin resistance induced by an acute lipid load

Comparison of mechanisms underlying changes in glucose utilization in fasted rats anesthetized with propofol or sevoflurane: Hyperinsulinemia is exaggerated by propofol with concomitant insulin resistance induced by an acute lipid load

Administration of low dose of glucose suppresses catabolism under general anaesthesia maintained with remifentanil

Hypoglycemia in Laparoscopic Colectomy with Remifentanil Use and Preoperative Intravenous Glucose Infusion: A Prospective, Randomized, Single-Blind, Controlled Trial

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