Effect of Intraoperative Platelet-Rich Plasma Treatment on Postoperative Donor Site Knee Pain in Patellar Tendon Autograft Anterior Cruciate Ligament Reconstruction: A Double-Blind Randomized Controlled Trial

Walters, Brian L.; Porter, David A.; Hobart, Sarah J.; Bedford, Benjamin B.; Hogan, Daniel; McHugh, Malachy; Klein, Devon A.; Harousseau, Kendall; Nicholas, Stephen

doi:10.1177/0363546518769295

Cited by 43 publications

(90 citation statements)

References 43 publications

(59 reference statements)

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“…Three studies were at high risk of bias for two domains [36,39,43], eight studies were at high risk of bias for one domain [30,[32][33][34][35]40,42,44], and one study was at high risk of bias for two domains with a risk of reporting bias for one domain [38]. High risk of performance bias was identified in one study [38], a moderate risk of performance bias was identified in twelve studies [30,[32][33][34][35][36]39,40,[42][43][44]46], and a low risk of performance bias was identified in three studies [29,31,41].…”

Section: Anterior Cruciate Ligament Reconstruction (Acl)mentioning

confidence: 98%

“…Sixteen RCTs, including 740 patients, evaluated the use of PRP as an adjunct to ACL reconstruction with patellar ligament (Bone-Patella Tendon-Bone-BPTB) autograft [29][30][31][32][33][34][35] or hamstrings graft [33,[36][37][38][39][40][41][42][43][44] (Table 6).…”

Section: Anterior Cruciate Ligament Reconstruction (Acl)mentioning

confidence: 99%

“…Seven studies reported functional results via IKDC scores [30,32,34,38,39,43,44], but only four of them provided data allowing for synthesis [30,32,43,44] ( Figure 7B) and no significant differences (p Seven studies reported functional results via IKDC scores [30,32,34,38,39,43,44], but only four of them provided data allowing for synthesis [30,32,43,44] ( Figure 7B) and no significant differences (p = 0.83) were detected. A further four studies provided only categorical output data (excellent, good, regular, poor) with non-significant odds ratio (1.39 (0.27, 7.21), p = 0.7).…”

Section: Anterior Cruciate Ligament Reconstruction (Acl)mentioning

confidence: 99%

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The Clinical Use of Platelet-Rich Plasma in Knee Disorders and Surgery—A Systematic Review and Meta-Analysis

Tramś

Kulinski

Kozar-Kamińska

et al. 2020

Life

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In recent years, the interest in biological treatment of knee lesions has increased, especially the application of platelet-rich plasma is of particular note. The number of articles evaluating platelet-rich plasma (PRP) efficacy in the recovery of knee disorders and during knee surgery has exponentially increased over the last decade. A systematic review with meta-analyses was performed by assessing selected studies of local PRP injections to the knee joint. The study was completed in accordance with 2009 Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. A multistep search of PubMed, Embase, Cochrane Database of Systematic Reviews, and Clinicaltrials.gov was performed to identify studies on knee surgery and knee lesion treatment with PRP. Of the 4004 articles initially identified, 357 articles focusing on knee lesions were selected and, consequently, only 83 clinical trials were analyzed using the revised Cochrane risk-of-bias tool to evaluate risk. In total, seven areas of meta-analysis reported a positive effect of PRP. Among them, 10 sub-analyses demonstrated significant differences in favor of PRP when compared to the control groups (p < 0.05). This study showed the positive effects of PRP, both on the recovery of knee disorders and during knee surgery; however further prospective and randomized studies with a higher number of subjects and with lower biases are needed.

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Section: Anterior Cruciate Ligament Reconstruction (Acl)mentioning

confidence: 98%

Section: Anterior Cruciate Ligament Reconstruction (Acl)mentioning

confidence: 99%

Section: Anterior Cruciate Ligament Reconstruction (Acl)mentioning

confidence: 99%

See 1 more Smart Citation

The Clinical Use of Platelet-Rich Plasma in Knee Disorders and Surgery—A Systematic Review and Meta-Analysis

Tramś

Kulinski

Kozar-Kamińska

et al. 2020

Life

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“…In a randomized controlled trial, Cervellin et al found that patients who had PRP applied to the patellar tendon donor site following ACL reconstruction experienced a significant decrease in knee pain and improved function at 1 year [38•]. This finding, however, has not been consistent in the literature [40]. Walters et al recently performed a randomized control trial examining the use of PRP in reducing kneeling pain at the donor site of ACL reconstruction [40].…”

Section: Patellar Tendinopathymentioning

confidence: 99%

“…Walters et al recently performed a randomized control trial examining the use of PRP in reducing kneeling pain at the donor site of ACL reconstruction [40]. Their study found no difference in kneeling pain at interval follow-up between patients who received PRP versus placebo [40].…”

Section: Patellar Tendinopathymentioning

confidence: 99%

Platelet-Rich Plasma: Review of Current Literature on its Use for Tendon and Ligament Pathology

Kia

Baldino

Bell

et al. 2018

Curr Rev Musculoskelet Med

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Recent literature has shown moderate- to high-quality evidence that PRP can have positive clinical effects in certain conditions such as lateral epicondylitis and rotator cuff tendinopathy. Prospective studies have shown that it can also be useful in the treatment of patella tendinopathy. In summary, we found PRP to have variable success in ligament and tendon pathology; however, it should be considered a viable option in chronic musculoskeletal disease that has failed other treatments. Patient selection, duration of symptoms, and combining with other modalities such as physical therapy should all be taken into consideration in treatment with PRP.

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Platelet‐rich plasma augmentation in anterior cruciate ligament reconstruction: Evidence is still too scattered. A scoping review of randomised controlled trials

Delcogliano,

Sangiorgio,

Bensa

et al. 2024

Knee surg. sports traumatol. arthrosc.

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PurposePlatelet‐rich plasma (PRP) augmentation has been proposed to improve the results of anterior cruciate ligament reconstruction (ACLR). The present study aims to quantify the available evidence to support the use of PRP as biological augmentation in ACLR surgery.MethodsA systematic literature search was conducted on the PubMed, Cochrane, Web of Science and Embase databases on 10 March 2023. Inclusion criteria were randomised controlled trials (RCTs), written in English, addressing PRP augmentation in ACLR surgery, with no time limitation. A scoping review was performed to map the body of literature by examining the evidence related to specific aspects of patients' treatment and evaluation. Risk of bias evaluation was performed with the Cochrane risk‐of‐bias tool for randomised trials Version 2 (RoB 2), while the quality assessment was performed with the use of the Coleman Score.ResultsOut of 983 articles retrieved, 23 RCTs on 943 knees were included in this scoping review. PRP was administered in a liquid form in nine studies and clotted in 11 studies, while in three studies both liquid and clotted PRP were used. Hamstring auto/allografts were used in 14 studies, patellar tendon auto/allografts were used in eight studies and one study described ACLR with peroneus longus allografts. The map of the evidence documented high heterogeneity also in terms of surgical technique, objective and subjective outcome measures and radiological assessment, as well as follow‐up times ranging from 1 day to 2 years, with virtually no overlapping data among studies neither in terms of treatments nor evaluations. Risk of bias evaluation showed an overall low quality of the included studies.ConclusionsThe available literature addressing PRP augmentation in ACLR is largely scattered. PRP was produced and applied following different procedures, and high variability was detected across the included studies for every aspect of ACLR surgery and evaluation. Currently, a meaningful comparison of the available studies is not possible as the quantification of the literature results is biased by their heterogeneity. Future studies should provide more standardisation to investigate the benefits of biological augmentation in ACL surgery and confirm the promising yet weak evidence of PRP potential as well as the most suitable application modality, before routine use in clinical practice.Level of EvidenceLevels I and II, scoping review.

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Effect of Intraoperative Platelet-Rich Plasma Treatment on Postoperative Donor Site Knee Pain in Patellar Tendon Autograft Anterior Cruciate Ligament Reconstruction: A Double-Blind Randomized Controlled Trial

Abstract: Whether randomized to receive PRP in their patellar defect or not, patients continued to have similar levels of kneeling pain and patellar defect sizes after autograft BPTB ACL reconstruction. Registration: NCT01765712 ( ClinicalTrials.gov identifier).

Cited by 43 publications

References 43 publications

The Clinical Use of Platelet-Rich Plasma in Knee Disorders and Surgery—A Systematic Review and Meta-Analysis

The Clinical Use of Platelet-Rich Plasma in Knee Disorders and Surgery—A Systematic Review and Meta-Analysis

Platelet-Rich Plasma: Review of Current Literature on its Use for Tendon and Ligament Pathology

Platelet‐rich plasma augmentation in anterior cruciate ligament reconstruction: Evidence is still too scattered. A scoping review of randomised controlled trials

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