Effect of intrapartum antibiotics on the intestinal microbiota of infants: a systematic review

Zimmermann, Petra; Curtis, Nigel

doi:10.1136/archdischild-2018-316659

Cited by 68 publications

(61 citation statements)

References 80 publications

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“…It is plausible that the moderate-late preterm infant intestine is not developmentally ready for this type of colonization. Alternatively, the extended hospital stay of preterm infants leads to dysbiosis due to a difference in environmental exposures from a home setting (Schwiertz et al, 2003;Magne et al, 2006;Roudière et al, 2009;Rougé et al, 2010;Jacquot et al, 2011), and antibiotic use intrapartum or direct use for neonates (Zimmermann and Curtis, 2019) may have contributed to the low abundances regardless of nutrition source.…”

Section: Discussionmentioning

confidence: 99%

Comparing Gut Microbiome in Mothers’ Own Breast Milk- and Formula-Fed Moderate-Late Preterm Infants

Wang

Neupane

et al. 2020

Front. Microbiol.

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Gut microbiome plays an important role in adult human health and diseases. However, how nutritional factors shape the initial colonization of gut bacteria in infants, especially in preterm infants, is still not completely known. In this study, we compared the effects of feeding with mothers' own breast milk (MBM) and formula on the initial composition and gene expression of gut bacteria in moderate-late preterm infants. Fecal samples were collected from ten formula-fed and ten MBM healthy infants born between 32 and 37 weeks' gestation after they reached full-volume enteral feedings. Total DNAs were extracted from fecal samples for amplicon sequencing of 16S ribosomal RNA (rRNA) gene and total RNA with rRNA depletion for metatranscriptome RNA-Seq 16S rRNA gene amplicon sequencing results showed that the alpha-diversity was similar between the MBM-and formula-fed preterm infants, but the beta-diversity showed a significant difference in composition (p = 0.002). The most abundant taxa were Veillonella (18.4%) and Escherichia/Shigella (15.2%) in MBM infants, whereas the most abundant taxa of formula-fed infants were Streptococcus (18.6%) and Klebsiella (17.4%). The genera Propionibacterium, Streptococcus, and Finegoldia and order Clostridiales had significantly higher relative abundance in the MBM group than the formula group, whereas bacteria under family Enterobacteriaceae, genera Enterococcus and Veillonella, and class Bacilli were more abundant in the formula group. In general, microbiomes from both diet groups exhibited high functional levels of catalytic activity and metabolic processing when analyzed for gene ontology using a comparative metatranscriptome approach. Statistically, the microbial genes in the MBM group had an upregulation in expression related to glycine reductase, periplasmic acid stress response in Enterobacteria, acid resistance mechanisms, and L-fucose utilization. In contrast, the formula-fed group had upregulations in genes associated with methionine and valine degradation functions. Our data suggest that the nutritional source plays a role in shaping the moderate-late preterm gut microbiome as evidenced by the

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Section: Discussionmentioning

confidence: 99%

Comparing Gut Microbiome in Mothers’ Own Breast Milk- and Formula-Fed Moderate-Late Preterm Infants

Wang

Neupane

et al. 2020

Front. Microbiol.

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“…41 While the effect of delivery mode and feeding methods on the establishment of microbial communities has been well studied, much less is known about the effects of intrapartum and early-life antibiotic exposure on the establishment of microbial communities in the intestinal microbiome. 13 A number of commonly used antibiotics have profound effects on specific bacteria within the intestinal microbiome, as detailed in a recent systematic review. 12 This 'collateral damage' includes changes in diversity and abundance of microbial taxa, a decrease in 'colonisation resistance' (protection against colonisation with potentially pathogenic organisms) and the development of antibiotic resistance.…”

Section: Discussionmentioning

confidence: 99%

“…Infants who were exposed to IAP have been reported to have a lower alphadiversity, a lower relative abundance of actinobacteria, especially Bifidobacteriaceae, and a larger relative abundance of proteobacteria in their intestinal microbiome compared with non-exposed infants. 13 Furthermore, they have been reported to have a higher number of betalactamase encoding genes. 43 Breast feeding has been shown to be beneficial in preventing many communicable and non-communicable diseases.…”

Section: Discussionmentioning

confidence: 99%

Study protocol for the ABERRANT study: antibiotic-induced disruption of the maternal and infant microbiome and adverse health outcomes — a prospective cohort study among children born at term

Volery

Scherz

Jakob³

et al. 2020

BMJ Open

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IntroductionThere is compositional overlap between the maternal intestinal microbiome, the breast milk microbiome and the infant oral and intestinal microbiome. Antibiotics cause profound changes in the microbiome. However, the effect of intrapartum and early-life antibiotics on the maternal intestinal and breast milk microbiome, and the infant oral and intestinal microbiome, and whether effects are only short term or persist long term remain uncertain.Methods and analysesIn this prospective cohort study, we will use metagenomic sequencing to determine: (1) the effect of intrapartum antibiotics on the composition of the breast milk, and the infant oral and intestinal microbiome, including the development and persistence of antibiotic resistance; (2) the effect of antibiotic exposure in the first year of life on the composition of the infant oral and intestinal microbiome, including the development and persistence of antibiotic resistance; (3) the effect of disruption of the infant oral and intestinal microbiome on health outcomes and (4) the compositional overlap between the maternal intestinal microbiome, the breast milk microbiome and the infant oral and intestinal microbiome.Ethics and disseminationThe ABERRANT study has been approved by the commission cantonale d’éthique de la recherche sur l’être humain (CER-VD) du Canton de Vaud (#2019–01567). Outcomes will be disseminated through publication and will be presented at scientific conferences.Trial registration numberNCT04091282.

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“…Retrospective (birth registry) (Lin et al, 2010) 152 related to bacterial resistance and the development of gut microbiome (van Wattum et al, 2019;Zimmermann and Curtis, 2020). Therefore, the use of antibiotics to regulate gut microbiome during pregnancy should be carefully considered.…”

Section: Reasonable Use Of Antibioticsmentioning

confidence: 99%

Regulating Gut Microbiome: Therapeutic Strategy for Rheumatoid Arthritis During Pregnancy and Lactation

Yao¹,

Cai²,

Fei³

et al. 2020

Front. Pharmacol.

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Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial inflammation and bone destruction. Microbial infection is considered to be the most important inducement of RA. The pregnancy planning of women in childbearing age is seriously affected by the disease activity of RA. Gut microbiome, related to immunity and inflammatory response of the host. At present, emerging evidence suggested there are significant differences in the diversity and abundance of gut microbiome during pregnancy and lactation, which may be associated with the fluctuation of RA disease activity. Based on these research foundations, we pioneer the idea of regulating gut microbiome for the treatment of RA during pregnancy and lactation. In this review, we mainly introduce the potential treatment strategies for controlling the disease activity of RA based on gut microbiome during pregnancy and lactation. Besides, we also briefly generalize the effects of conventional anti-rheumatic drugs on gut microbiome, the effects of metabolic changes during pregnancy on gut microbiome, alteration of gut microbiome during pregnancy and lactation, and the effects of anti-rheumatic drugs commonly used during pregnancy and lactation on gut microbiome. These will provide a clear knowledge framework for researchers in immune-related diseases during pregnancy. Regulating gut microbiome may be a potential and effective treatment to control the disease activity of RA during pregnancy and lactation.

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Effect of intrapartum antibiotics on the intestinal microbiota of infants: a systematic review

Cited by 68 publications

References 80 publications

Comparing Gut Microbiome in Mothers’ Own Breast Milk- and Formula-Fed Moderate-Late Preterm Infants

Comparing Gut Microbiome in Mothers’ Own Breast Milk- and Formula-Fed Moderate-Late Preterm Infants

Study protocol for the ABERRANT study: antibiotic-induced disruption of the maternal and infant microbiome and adverse health outcomes — a prospective cohort study among children born at term

Regulating Gut Microbiome: Therapeutic Strategy for Rheumatoid Arthritis During Pregnancy and Lactation

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