Effect of Intraperitoneal Neutrophils Induced by OK432 on Malignant Ascites

Our study demonstrated that the levels of pro-inflammatory proteins (MIF and IL-6) that we tested were higher in the fetal pleural effusion than in the fetal circulation, a phenomenon not observed in the levels of proangiogenic proteins (HGF, SDF-1, VEGF, IL-8). This result implies that inflammation-related proteins may be more relevant than the angiogenesis-related proteins in the local environment of accumulating pleural effusion, a prominent feature of prenatal chylothorax.

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Proinflammatory macrophage migratory inhibition factor and interleukin‐6 are concentrated in pleural effusion of human fetuses with prenatal chylothorax

Chen

Hsieh

Shih

et al. 2007

Prenatal Diagnosis

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Effect of Intraperitoneal Neutrophils Induced by OK432 on Malignant Ascites

Abstract: OK432 effectively activated intraperitoneal neutrophils and a series of immunological chain reactions through an increase in IL-1beta, IL-6, and MIP-1alpha levels. Milky spots could have important antitumor effects in terms of the spread of neutrophils.

Cited by 1 publication

References 33 publications

Proinflammatory macrophage migratory inhibition factor and interleukin‐6 are concentrated in pleural effusion of human fetuses with prenatal chylothorax

Proinflammatory macrophage migratory inhibition factor and interleukin‐6 are concentrated in pleural effusion of human fetuses with prenatal chylothorax

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