Effect of Intraperitoneal Thymoquinone on Postoperative Peritoneal Adhesions

Bozdağ, Zübeyir; Gümüş, Metehan; Arıkanoğlu, Zülfü; İbiloğlu, İbrahim; Kaya, Selçuk; Evliyaoğlu, Osman

doi:10.1080/00015458.2015.11681129

Cited by 5 publications

(5 citation statements)

References 20 publications

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“…The grade of inflammation, hydroxyproline content were also significantly lower in the TQ administered group. These findings were correlated with the total antioxidant capacity of the samples which were significantly higher in the TQ administered group showing that the antioxidant effect of TQ is also responsible for the reduction in peritoneal adhesion scores in the TQ group [28]. …”

Section: Discussionmentioning

confidence: 99%

The effect of thymoquinone coating on adhesive properties of polypropylene mesh

et al. 2017

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BackgroundAn incisional hernia is a common complication following abdominal surgery. Polypropylene mesh is frequently used in the repair of such defects and has nearly become the standard surgical treatment modality. Though they are very effective in reducing recurrence, mesh materials exhibit a strong stimulating effect for intraabdominal adhesion. The thymoquinone (TQ) extracted from Nigella sativa seeds has potential medical properties. TQ has anti-inflammatory, antioxidant and antibacterial properties. The aim of this study is to coat polypropylene mesh with TQ in order to investigate the effect of surface modification on intraabdominal adhesions.MethodsTQ-coated polypropylene mesh material was tested for cytotoxicity, contact angle, surface spectroscopy, TQ content, sterility, and electron microscopic surface properties. An experimental incisional hernia model was created in study groups, each consisting of 12 female Wistar rats. The defect was closed with uncoated mesh in control group, with polylactic acid (PLA) coated mesh and PLA-TQ coated mesh in study groups. Adhesion scores and histopathologic properties were evaluated after sacrifice on postoperative 21th day.ResultsGranuloma formation, lymphocyte and polymorphonuclear leukocyte infiltration, histiocyte fibroblast and giant cell formation, capillary infiltration, collagen content were significantly reduced in the PLA-TQ coated mesh group (p < 0.05). Though not statistically significant, likely due to the limited number of study animals, adhesion formation was also reduced in the PLA-TQ coated mesh group (p: 0.067).ConclusionTQ coated mesh is shown to reduce adhesion formation and TQ is a promising coating material for mesh surface modification.Electronic supplementary materialThe online version of this article (doi:10.1186/s12893-017-0239-5) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

The effect of thymoquinone coating on adhesive properties of polypropylene mesh

et al. 2017

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“…As our study demonstrated, it can be assumed that the anti-inflammatory and immunomodulator effect of TQ can be a result of its action on the anastomotic healing. In a study by Bozdag et al, intraperitoneally applied TQ was shown to decrease the hydroxyproline level and intraabdominal adhesions (Bozdag et al 2015 ). In the present study, orally administered TQ was demonstrated to increase the hydroxyproline levels on the anastomotic line.…”

Section: Discussionmentioning

confidence: 99%

Effect of thymoquinone on the healing of left colon anastomosis: an experimental study

et al. 2016

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AimTo evaluate the effect of thymoquinone on the healing of experimental left colon anastomosis in rats.MethodsForty Wistar albino rats weighing 250–300 g were randomly divided into four groups (10 rats/group). Group 1 (control group) rats were not administered Thymoquinone (TQ) for 3 days after the operation. Group 2 was administered daily TQ for 3 days starting from the first day after the operation. Group 3 was not administered TQ for 7 days after the operation. Group 4 was administered daily TQ for 7 days starting from the first day after the operation. Thymoquinone was administered as a single dose oral gavage through a 4F feeding catheter per each day. The bursting strength of the anastomosis was measured on 3rd and 7th postoperative days (POD) and resection was performed. Subsequently, the hydroxyproline level in the resected tissue was measured and a histological evaluation was performed.ResultsThe bursting pressures of the anastomoses were measured to be statistically significantly greater on 7th POD in TQ administered groups compared to those without TQ administration. Tissues were stained with Masson’s trichrome dye in order to evaluate the amount of fibrous tissue reaction for histopathological examination; there was no significant difference in the amount of fibrous tissue between groups 1 and 2, while a very marked increase in the fibrous tissue was detected in groups 3 and 4. Mean tissue hydroxyproline levels of the groups 3 and 4 on 7th POD were 1.30 and 2.72 μg/g-protein, respectively. The difference between the groups was statistically significant (p = 0.001).ConclusionsTQ significantly increased the bursting pressure of the anastomosis, tissue hydroxyproline level, and fibrous tissue production.

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“…Through the inhibition of prostaglandin and thromboxane, NSAIDs decrease vascular permeability, inhibitors of plasmin, platelet aggregation, coagulation and increase macrophage activity. NSAIDs modulate different aspects of inflammation and reduce the formation of adhesions in most animal models [ 39 ]…”

Section: Management and Preventive Strategies For Adhesionsmentioning

confidence: 99%

Prevention and treatment of peritoneal adhesions in patients affected by vascular diseases following surgery: a review of the literature

Rocca

Aprea

Surfaro³

et al. 2016

Open Medicine

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AbstractIntra-abdominal adhesions are the most frequently occurring postoperative complication following abdomino-pelvic surgery. Abdominal and pelvic surgery can lead to peritoneal adhesion formation causing infertility, chronic pelvic pain, and intestinal obstruction. Laparoscopy today is considered the gold standard of care in the treatment of several abdominal pathologies as well as in a wide range of vascular diseases. Laparoscopy has several advantages in comparison to open surgery. These include rapid recovery times, shorter hospitalisation, reduced postoperative pain, as well as cosmetic benefits. The technological improvements in this particular surgical field along with the development of modern techniques and the acquisition of specific laparoscopic skills have allowed for its wider utilization in operations with fully intracorporeal anastomoses. Postoperative adhesions are caused by aberrant peritoneal healing and are the leading cause of postoperative bowel obstruction. The use of anti-adherence barriers is currently being advocated for their prevention. The outcome of the investigation showed adhesion formation inhibition without direct detrimental effects on anastomotic healing. Poor anasto-motic healing can provoke adhesions even in the presence of anti-adhesion barriers. This review gives a short overview on the current evidence on the pathophysiology and prevention of peritoneal adhesions.

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Effect of Intraperitoneal Thymoquinone on Postoperative Peritoneal Adhesions

Abstract: Based on the results of this study in a rat peritoneal adhesion model, intraperitoneal administered thymoquinone has a strong anti-adhesive effect.

Cited by 5 publications

References 20 publications

The effect of thymoquinone coating on adhesive properties of polypropylene mesh

The effect of thymoquinone coating on adhesive properties of polypropylene mesh

Effect of thymoquinone on the healing of left colon anastomosis: an experimental study

Prevention and treatment of peritoneal adhesions in patients affected by vascular diseases following surgery: a review of the literature

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