Effect of Intrasilicone Bevacizumab Injection in Diabetic Tractional Retinal Detachment Surgery: A Retrospective Case-Control Study

Baek, Seung Kook; Lee, Minwoo; Lee, Younghoon

doi:10.3390/jcm9103114

Cited by 7 publications

(13 citation statements)

References 43 publications

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“…Two, both published in the European Vitreoretinal Society (EVRS) Educational Electronic Journal, where irretrievable from Queen’s University library (Belfast, UK) and The British Library (London, UK) and could not be assessed. After full-text evaluation of all other studies, 38 (with 3839 eyes) were found eligible and included . Patients had a median (IQR) age of 52.2 (49.6-55.7) years.…”

Section: Resultsmentioning

confidence: 99%

“…The meta-analysis of overall final VA included 20 studies 5,17,19,[22][23][24][26][27][28]30,[32][33][34]36,37,39,44,45,50,51 (1526 eyes). The pooled final BCVA was 0.94 (95% CI, 0.82-1.05) logMAR (approximate Snellen equivalent, 6/53; 95% CI, 6/39-6/71) (Figure 2).…”

Section: Outcomes Of Trd Repairmentioning

confidence: 99%

“…29 The latter was deemed poor as it did not specify the method of randomization, whether there was allocation concealment, and did not have justification of the sample size. There was 1 case-control study 27 and 1 observational cohort study. Both were assessed as being of good quality.…”

Section: Quality Assessment Of Included Studiesmentioning

confidence: 99%

“…The remaining 35 studies were assessed using the beforeafter study tool 11 of which 19 were graded good 5,16,17,24,26,27,30,[32][33][34]36,37,40,44,46,[48][49][50][51] ; 15 fair 6,[18][19][20][21]23,25,28,31,38,[41][42][43]45,47 ; and the remaining study as poor. 35 This latter study was given a poor rating as outcomes and inclusion-exclusion criteria were not predefined.…”

Section: Quality Assessment Of Included Studiesmentioning

confidence: 99%

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Outcomes and Complications of Pars Plana Vitrectomy for Tractional Retinal Detachment in People With Diabetes

et al. 2023

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ImportanceTractional retinal detachment (TRD) occurs in approximately 5% of people with proliferative diabetic retinopathy and poses a threat to vision. Pars plana vitrectomy (PPV) is the treatment of choice for TRD.ObjectiveTo determine anatomic and functional outcomes of PPV for the treatment of TRD in people with diabetes (dTRD).Data SourcesMEDLINE and Embase were searched systematically from January 1, 2000, to February 20, 2022. In addition, a reference list of eligible studies were screened.Study SelectionEligible studies were those published in English, those reporting outcomes of PPV for dTRD, and those that included more than 25 eyes and with a minimum follow-up of 3 months.Data Extraction and SynthesisPreferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines for data extraction/synthesis were followed, and the National Institute for Health quality assessment tool was used to assess risk of bias. Study eligibility was determined independently by 2 reviewers; data extraction was conducted by 1 reviewer and entries checked for accuracy by another. Data were pooled using a random-effects model.Main Outcomes and MeasuresMain outcomes included rate of failure of retinal reattachment following 1 surgery and final visual acuity (VA). The association of baseline patient characteristics and surgical maneuvers with postoperative surgical outcomes was investigated.ResultsOf the 406 studies identified, 38 (3839 eyes) were eligible and included for analysis. Patients had a median (IQR) age of 52.2 (49.6-55.7) years. In the studies reporting patient sex (31 of 38 studies), 1441 were female individuals (50.1%). The overall failure rate of retinal reattachment after 1 surgery was 5.9% (95% CI, 1.4%-8.3%), and the mean final VA was 0.94 (95% CI, 0.82-1.05) logMAR (approximate Snellen equivalent, 6/53; 95% CI, 6/39-6/71). People with higher preoperative VA achieved higher postoperative vision (0.66 logMAR worse final vision; 95% CI, 0.39-0.84 per 1.0 logMAR worse at baseline; P &lt;.001). On multivariable analysis, no other patient characteristics or surgical variables had a statistically significant association with outcomes.Conclusions and RelevanceResults of this systematic review and meta-analysis suggest that PPV was an effective strategy to achieve retinal reattachment in people with dTRD. Given that higher preoperative VA was the only factor associated with higher postoperative vision, early intervention should be considered and discussed in detail with patients. Overall, final postoperative VA remains low, and patients should be counseled on the guarded prognosis of dTRD.

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Section: Resultsmentioning

confidence: 99%

Section: Outcomes Of Trd Repairmentioning

confidence: 99%

Section: Quality Assessment Of Included Studiesmentioning

confidence: 99%

Section: Quality Assessment Of Included Studiesmentioning

confidence: 99%

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Outcomes and Complications of Pars Plana Vitrectomy for Tractional Retinal Detachment in People With Diabetes

et al. 2023

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“…PPV'nin hemen bitiminde göz içi silikon ile birlikte yarım doz intravitreal Anti-VEGF enjeksiyonu da yapılabilmektedir. [21] KTRRD' de makulanın yatışıklığı cerrahi başarıyı etkileyen önemli bir faktördür. Storey ve ark.…”

Section: Diyabetik Kombine Traksiyonel-regmatojen Retina Dekolmanında...unclassified

Surgical Treatment of Diabetic Combined Tractional-Rhegmatogenous Retinal Detachment

2023

Güncel Retina (Current Retina)

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Diabetic macular edema, tractional retinal detachment (TRD) and combined rhegmatogenous retinal detachment (CTRRD) are important causes of vision loss in eyes with proliferative diabetic retinopathy. CTRRD is less common than TRD but has a worse prognosis. Therefore, the treatment of CTRRD is one of the issues that await solutions in current ophthalmology practice. In recent years, it has been shown that the risk of intraocular bleeding during and after the operation is reduced by the use of vascular endothelial growth factor inhibitors before the operation. In addition to bimanual surgery, there are current developments that enable the effective and safe application of segmentation and delamination of proliferative membranes with customized rapid cutters from vitreoretinal small incisions. In addition, the preference for silicone oil as an intraocular tamponade and intraoperative real-time follow-up of vitrectomy with optical coherence tomography has the potential to provide more successful anatomical and functional results.

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Current Situation and Challenges in Vitreous Substitutes

García

Bandín-Vilar

García-Quintanilla

et al. 2021

Macromolecular Bioscience

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Vitreo‐retinal disorders constitute a significant portion of treatable ocular diseases. These pathologies often require vitreo‐retinal surgery and, as a consequence, the use of vitreous substitutes. Nowadays, the vitreous substitutes that are used in clinical practice are mainly divided into gases (air, SF6, C2F6, C3F8) and liquids (perfluorocarbon liquids, silicone oils, and heavy silicone oils). There are specific advantages and drawbacks to each of these, which determine their clinical indications. However, developing the ideal biomaterial for vitreous substitution continues to be one of the most important challenges in ophthalmology, and a multidisciplinary approach is required. In this sense, recent research has focused on the development of biocompatible, biodegradable, and injectable hydrogels (natural, synthetic, and smart), which also act as medium and long‐term internal tamponade agents. This comprehensive review aims to cover the main characteristics and indications for use of the extensive range of vitreous substitutes that are currently used in clinical practice, before going on to describe the hydrogels that have been developed recently and which have emerged as promising biomaterials for vitreous substitution.

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Effect of Intrasilicone Bevacizumab Injection in Diabetic Tractional Retinal Detachment Surgery: A Retrospective Case-Control Study

Cited by 7 publications

References 43 publications

Outcomes and Complications of Pars Plana Vitrectomy for Tractional Retinal Detachment in People With Diabetes

Outcomes and Complications of Pars Plana Vitrectomy for Tractional Retinal Detachment in People With Diabetes

Surgical Treatment of Diabetic Combined Tractional-Rhegmatogenous Retinal Detachment

Current Situation and Challenges in Vitreous Substitutes

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