Effect of intrathecal clonidine versus fentanyl on bupivacaine spinal block in transurethral resection of prostate surgeries

Singh, Gurpreet; Aulakh, Gurmehar Singh; Aulakh, Navpreet Kaur; Singh, Rupinder M; Bose, Abhishek; Katayal, Sunil; Aulakh, Baldev Singh

doi:10.4103/0259-1162.165513

Cited by 3 publications

(2 citation statements)

References 22 publications

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“…in their study in patients posted for transurethral resection of prostate concluded that intrathecal clonidine in a combination with bupivacaine provides more satisfactory anesthesia and analgesia and has less side effects compared to fentanyl which was similar to our finding. [ 28 ] All above studies have used intrathecal clonidine in doses from 15 μg to 150 μg, but use of intrathecal clonidine in dose of 50 μg provided prolonged postoperative analgesia with minimum side effects compared to fentanyl and other different doses of clonidine.…”

Section: Discussionmentioning

confidence: 99%

Comparison of intrathecal clonidine and fentanyl as adjuvant to hyperbaric bupivacaine in subarachnoid block for lower limb orthopedic surgery

Routray

Raut

Pradhan³

et al. 2017

Anesth Essays Res

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Background:Many studies are there using adjuvants such as clonidine and fentanyl with bupivacaine in the subarachnoid block for prolonging postoperative analgesia. However, literature is divided regarding the dosage and efficacy of both intrathecal adjuvants. Furthermore, these adjuvants have their own side effects. Hence, search for ideal intrathecal adjuvant between clonidine and fentanyl to bupivacaine goes on.Aim:The aim of the present study was to compare the effect of intrathecal clonidine and fentanyl as adjuvant to bupivacaine in the subarachnoid block for lower limb orthopedic surgery.Materials and Methods:It was a prospective randomized study in which eighty patients posted for lower limb orthopedic surgery were divided into two groups of forty each. Group C – Received intrathecal hyperbaric bupivacaine (2.5 ml) +50 μg clonidine (diluted to 0.5 ml). Group F – Received intrathecal hyperbaric bupivacaine (2.5 ml) + fentanyl 25 μg (diluted to 0.5 ml). Duration of postoperative analgesia, sensory and motor block characteristics, hemodynamic parameters, and side effects were recorded and analyzed.Results:Time for first dose of rescue analgesic was delayed in Group C (510.84 ± 24.10 min) in comparison to Group F (434.95 ± 19.16 min) which was statistically significant (P < 0.001). Duration of sensory and motor block was significantly prolonged in Group C compared to Group F (P < 0.001). Sedation was more in Group C than Group F (P < 0.001). Other block characteristics, hemodynamic, and side effects were comparable in both groups.Conclusion:Intrathecal clonidine as adjuvant to hyperbaric bupivacaine provided prolonged postoperative analgesia with more sedation in comparison to intrathecal fentanyl.

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Section: Discussionmentioning

confidence: 99%

Comparison of intrathecal clonidine and fentanyl as adjuvant to hyperbaric bupivacaine in subarachnoid block for lower limb orthopedic surgery

Routray

Raut

Pradhan³

et al. 2017

Anesth Essays Res

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“…The estimated heating value of rice husk is approximately 15 MJ/kg [18]. In Asia and Africa, the annual generation of rice husk is 1.5 × 10 11 kg [64].…”

Section: Different Biomass Feedstock Materialsmentioning

confidence: 99%

Gasification Process Using Downdraft Fixed-Bed Gasifier for Different Feedstock

Hoque¹,

Rashid²

2021

Gasification [Working Title]

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The use of conventional fuels is decreasing globally due to its limited reserves and negative impact on the environment. The associated cost of conventional fuels is increasing owing to the higher demand for conventional fuels. Hence, utilization methods of biomass to generate energy are of growing interest. Among different biomass feedstocks, rice husks, waste plastics, and sawdust are significantly available in the global environment. The annual generation amount of rice husk is approximately 120 million tons worldwide, with an annual energy generation potential of 109 GJ with a heating value of 15 MJ/kg. The gasification process is assumed to be the most effective biomass conversion method that can generate synthetic gas to operate IC engines, fuel cells, and boilers. Synthetic gas production from biomass using a gasification process is a significant source of future energy. Downdraft fixed-bed gasifiers are considered as a feasible option of biomass conversion in the gasification process. By optimizing the operating conditions of downdraft fixed-bed gasifier, such as reaction zone temperature, combustion zone temperature, intake air temperature, airflow rate, the humidity of intake air, a significant amount of synthetic gas can be produced from rice husks, waste plastic material, and sawdust.

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Comparison of addition of fentanyl or clonidine to Intrathecal bupivacaine versus Intrathecal bupivacaine alone for lower limb surgeries in elderly patients: A prospective, randomised study: Intrathecal fentanyl/clonidine ± bupivacaine for surgery in elderly

Bhat,

Kamat,

Pai

et al. 2023

Serb J Anest Inten Therapy

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Orthopaedic long bone fracture surgeries in elderly patients have their own inherent risks during anaesthesia. We aimed to compare the effect of adding clonidine or fentanyl to low dose intrathecal bupivacaine as opposed to intrathecal bupivacaine alone. Materials and methods: A prospective, double-blind study was conducted in ninety elderly patients undergoing lower limb surgery under spinal anaesthesia. After randomly allocating the patients to three groups, Group BC [Bupivacaine + Clonidine]: 9 mg bupivacaine (0.5%) + clonidine 15 µg + saline, Group BF [ Bupivacaine + Fentanyl] : 9 mg bupivacaine (0.5% ) + fentanyl 20 µg, Group BS [Bupivacaine + Saline] : 9 mg bupivacaine (0.5%) + saline. The time for onset of sensory and motor block, highest sensory level achieved, time taken to achieve peak sensory and motor blockade, duration of analgesia and side-effects were compared between the three groups. The relevant statistical analyses were done. Results: The time taken for the sensory level and motor block to recede was the longest in group BC. The duration of analgesia was maximum in the group BC group and minimum in group BS. Incidence of hypotension and use of ephedrine was maximum in Group BC. Conclusion: Fentanyl or clonidine added to low dose intrathecal bupivacaine for lower limb surgery in the elderly significantly increases the duration of analgesia compared with intrathecal bupivacaine alone, clonidine more than fentanyl.

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Effect of intrathecal clonidine versus fentanyl on bupivacaine spinal block in transurethral resection of prostate surgeries

Cited by 3 publications

References 22 publications

Comparison of intrathecal clonidine and fentanyl as adjuvant to hyperbaric bupivacaine in subarachnoid block for lower limb orthopedic surgery

Comparison of intrathecal clonidine and fentanyl as adjuvant to hyperbaric bupivacaine in subarachnoid block for lower limb orthopedic surgery

Gasification Process Using Downdraft Fixed-Bed Gasifier for Different Feedstock

Comparison of addition of fentanyl or clonidine to Intrathecal bupivacaine versus Intrathecal bupivacaine alone for lower limb surgeries in elderly patients: A prospective, randomised study: Intrathecal fentanyl/clonidine ± bupivacaine for surgery in elderly

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