Effect of intravenous administration of romifidine on intraocular pressure in clinically normal horses

Marzok, Mohamed; El-Khodery, Sabry; Oheida, Aiman H.

doi:10.1111/vop.12181

Cited by 21 publications

(20 citation statements)

References 29 publications

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“…In the horse, IOP is reduced by sedation with romifidine alone (by up to 16.7%) (Marzok et al . ), xylazine alone (by up to 23%) (van der Woerdt et al . ) and a combination of acepromazine and xylazine (McClure et al .…”

Section: Ophthalmic Examinationmentioning

confidence: 99%

Equine ophthalmic examination: Routine diagnostic techniques

Seruca¹,

Lowe²

2015

Equine Veterinary Education

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Summary A complete, thorough ophthalmic examination is essential in the clinical approach to equine ocular diseases. In the majority of cases and more than in most systems, an ophthalmic diagnosis can be achieved at the time of examination because most ocular structures can be visualised either directly or indirectly. This article describes examination protocol and the techniques, instruments and diagnostic procedures currently available to equine general practitioners.

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Section: Ophthalmic Examinationmentioning

confidence: 99%

Equine ophthalmic examination: Routine diagnostic techniques

Seruca¹,

Lowe²

2015

Equine Veterinary Education

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“…The lack of ataxia with romifidine has made it very popular for sedating horses in standing procedures, and it is also widely used for premedication prior to induction of anaesthesia in this species (Marzok et al . ).…”

Section: Introductionmentioning

confidence: 97%

“…The use of alpha-2 adrenoceptor agonist drugs has gained wide acceptance in equine veterinary practice (Marzok et al 2014). Xylazine, detomidine and romifidine have currently been approved for use in Europe (Reg.…”

Section: Introductionmentioning

confidence: 99%

“…When compared with IV xylazine (1 mg/kg) or detomidine (20 lg/kg), romifidine at 40 and 80 lg/kg produced less ataxia and the horses' heads were held higher; furthermore, the duration of these effects was longer than the others. The lack of ataxia with romifidine has made it very popular for sedating horses in standing procedures, and it is also widely used for premedication prior to induction of anaesthesia in this species (Marzok et al 2014).…”

Section: Introductionmentioning

confidence: 99%

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Pharmacokinetic profile and partitioning in red blood cells of romifidine after single intravenous administration in the horse

Romagnoli¹,

Al-Qudah²,

Armorini

et al. 2017

Veterinary Medicine & Sci

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The aims of this study were to assess the plasma concentrations of romifidine in horses after intravenous injection, to evaluate the red blood cell (RBC) partitioning of the anaesthetic drug, and to improve knowledge regarding its sedative effect in horses describing the pharmacokinetic model. Eight adult Standardbred horses received a single bolus of romifidine at a dosage of 100 μg/kg. Blood samples (5 mL) were collected immediately before romifidine administration (t 0), and at 2, 5, 10, 15, 20, 25, 30, 40, 50, 60, 75, 90, 105, 120, 150 and 180 min after injection. A sedation score was recorded at the same time. The romifidine concentrations in plasma and red blood cells were determined by high performance liquid chromatography (HPLC). The plasma and red blood cell concentrations were correlated with the sedation at each time point. Romifidine produced a satisfactory level of sedation in all animals. The sedation was detectable in all horses for up to 105 min. All the animals returned to normal without any behavioural changes at 180 min. The romifidine concentrations in the red blood cells were significantly higher (P < 0.01) at all time points than those in the plasma. The T1/2β was 148.67 ± 61.59 min and body clearance was 22.55 ± 6.67 mL/kg per min. The results showed that after a single bolus administration of romifidine, a partitioning in the RBCs was detected.

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“…Thus, there are many considerations when evaluating equine IOP measurement. We deliberately did not sedate our test subjects for this study, as intravenous sedation with common agents such as xylazine, detomidine, and romifidine causes a significant decrease in measured equine IOP.…”

Section: Introductionmentioning

confidence: 99%

Effect of auriculopalpebral nerve block on equine intraocular pressure measured by rebound tonometry (TonoVet^®)

Diehl

Bowden

2020

Veterinary Ophthalmology

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Objective To assess rebound tonometry intraocular pressure (IOP) in unsedated horses without and with auriculopalpebral (AP) nerve blocks. Animals Studied Twenty‐two client‐ and twenty university‐owned horses (84 total eyes) with unremarkable ophthalmic examinations were evaluated. Procedure One eye of each horse was chosen randomly, an AP block performed for that eye, and IOP measured in both eyes with a TonoVet®. The process was repeated for the contralateral eye 72 hours later under the same conditions as the initial measurements. Horses were unsedated for nerve blocks and tonometry. Linear mixed‐effects models were used for comparisons with statistical significance threshold of 0.05. Results Overall, blocked eyes had an 0.8 mm Hg lower average IOP than unblocked eyes (P = .039). IOP for client‐owned horses was on average 3.2 mm Hg lower than in UGA‐owned horses (P = .025) and was more impacted by AP block (1.4 mm Hg lower average in client‐owned blocked versus unblocked eyes (P = .006)). Block effectiveness was ranked on a subjective scale (“good”, “poor”, no block/control), and IOP was on average lower in eyes with a good block (P = .008). Conclusion Although there were statistically significant differences in IOP between blocked and unblocked eyes, between client‐ and UGA‐owned horses, and between eyes with good and poor AP blocks, these differences were not clinically significant. Thus, AP blocks remain a useful tool for evaluating equine ophthalmic health with minimal impact on IOP assessment.

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Effect of intravenous administration of romifidine on intraocular pressure in clinically normal horses

Abstract: Romifidine significantly decreased IOP in clinically normal horses and may be used safely for surgery or diagnostic ocular procedures in horses when specific control of IOP is required.

Cited by 21 publications

References 29 publications

Equine ophthalmic examination: Routine diagnostic techniques

Equine ophthalmic examination: Routine diagnostic techniques

Pharmacokinetic profile and partitioning in red blood cells of romifidine after single intravenous administration in the horse

Effect of auriculopalpebral nerve block on equine intraocular pressure measured by rebound tonometry (TonoVet^®)

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Effect of intravenous administration of romifidine on intraocular pressure in clinically normal horses

Abstract: Romifidine significantly decreased IOP in clinically normal horses and may be used safely for surgery or diagnostic ocular procedures in horses when specific control of IOP is required.

Cited by 21 publications

References 29 publications

Equine ophthalmic examination: Routine diagnostic techniques

Equine ophthalmic examination: Routine diagnostic techniques

Pharmacokinetic profile and partitioning in red blood cells of romifidine after single intravenous administration in the horse

Effect of auriculopalpebral nerve block on equine intraocular pressure measured by rebound tonometry (TonoVet®)

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Effect of auriculopalpebral nerve block on equine intraocular pressure measured by rebound tonometry (TonoVet^®)