Effect of intravenous calcium administration on gastric secretion of acid and pepsin in man.

Smallwood, R A

doi:10.1136/gut.8.6.592

Cited by 40 publications

(13 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, as the patients were vagotomized the results are not directly comparable to those of the present study. The results also contrast with those of Smallwood (1967), who found that vagotomy inhibited the gastric hypersecretory effect of calcium administration.…”

Section: Discussioncontrasting

confidence: 99%

The effect of calcium on gastric acid and gastrin secretion in antrectomized subjects

Christiansen¹,

Rehfeld²,

Stadil³

1974

Gut

View full text Add to dashboard Cite

SUMMARY Serum gastrin concentrations and gastric acid secretion were measured in nine antrectomized subjects during infusion of saline and calcium gluconate. The basal gastrin level was of the same magnitude as in normal individuals and unoperated duodenal ulcer patients. Calcium infusion only induced gastrin release in one patient and did not induce acid secretion in any of the patients.The intravenous infusion of calcium stimulates gastric acid secretion in normal individuals (Reeder, Jackson, Ban, Clendinnen, Davidson, and Thompson, 1970) and in duodenal ulcer patients (Barreras and Donaldson, 1967 (Christiansen and Hendel, 1972).Studies by Reeder et al (1970) support the view that calcium exerts its effect on gastric acid secretion through the release of gastrin. Rosato, Mullen, Lanciault, Rosato, and Brooks (1973), who in conscious monkeys also found reproducible elevations in serum gastrin concentrations after calcium infusion, could not, however, demonstrate any correlation between serum gastrin concentration and gastric acid secretion.Further information on any relationship between calcium concentration and gastrin stimulation of acid secretion could be found by studying the effect of an infusion of calcium salts on the gastric acid secretion in patients in whom the antral source of gastrin had been removed. Material and MethodsNine patients were studied, eight men and one woman, ages ranging from 22 to 60 years, who had had an antrectomy for duodenal or prepyloric ulcer

show abstract

Section: Discussioncontrasting

confidence: 99%

The effect of calcium on gastric acid and gastrin secretion in antrectomized subjects

Christiansen¹,

Rehfeld²,

Stadil³

1974

Gut

View full text Add to dashboard Cite

show abstract

“…Such an explanation is supported by the observation that calcium-induced secretion is entirely eliminated following cholinergic blockade with atropine or pentolinium [7,96] or following vagotomy [96], While it is accepted that both procedures will markedly reduce the gastric response to other stimuli, by removing the background, potentiating, cholinergic activity, the inability of calcium infusions to augment the response to a background infusion of Mecholyl in vagotomised patients is further evidence that calcium is not acting directly on the gastric glands [96]. The effect of atropine has not been tested in animals, but it seems unlikely that anything so fundamental as transmitter release would show profound species differences, suggesting that other factors are responsible for the calcium-induced inhibition observed in most laboratory animals.…”

Section: Promotion O F Transmitter Releasementioning

confidence: 59%

Calcium and Gastrointestinal Secretion

Case¹

1973

Digestion

View full text Add to dashboard Cite

“…Barreras (1) found that atropine reversed ongoing calcium-stimulated gastric acid hypersecretion. Smallwood (8) found reduced gastric acid secretion after vagotomy with lower calcium doses. These results suggest that gastric acid secretion stimulated by calcium infusion deserves more study as a test of incomplete vagotomy.…”

Section: Discussionmentioning

confidence: 99%

Effect of Calcium Infusions on Serum Calcium and Gastric Acid Secretion

Hall¹,

Brändli²,

Read³

1976

Digestion

View full text Add to dashboard Cite

37 patients were studied with calcium infusions. Of these, 20 had previously undergone truncal vagotomy and pyloroplasty for duodenal ulcer disease, and 17 were unoperated patients with duodenal ulcer disease. Calcium was given intravenously either at a dose of 5 mg/kg/h for 3 h, or 4 mg/kg/h for 4 h. Gastric juice was collected by continuous suction. Results showed the 3-hour infusion raised calcium more than the 4-hour infusion. Top serum calcium achieved, however, did not correlate with calcium-stimulated gastric acid output, either with or without vagotomy. Stimulated gastric acid secretion was markedly less with vagotomy than without. It is suggested that the level of gastric acid stimulated by infusions might discriminate complete, from incomplete, vagotomies better than insulin, and that the 4-hour infusion is safer.

show abstract

Effect of intravenous calcium administration on gastric secretion of acid and pepsin in man.

Cited by 40 publications

References 21 publications

The effect of calcium on gastric acid and gastrin secretion in antrectomized subjects

The effect of calcium on gastric acid and gastrin secretion in antrectomized subjects

Calcium and Gastrointestinal Secretion

Effect of Calcium Infusions on Serum Calcium and Gastric Acid Secretion

Contact Info

Product

Resources

About