Effect of Intravenous Contrast Media on Proximal and Distal Tubular Hydrostatic Pressure in the Rat Kidney

Ueda, J.; Nygren, A.; Hansell, Peter; Ulfendahl, H. R.

doi:10.3109/02841859309173242

Cited by 45 publications

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“…This will lead to a high intratubular viscosity, which will also be a result of the large dimeric iotrolan molecule. This has been shown by UEDA et al (20) to result in an extremely high intratubular hydrostatic pressure. We propose that by this action iotrolan may reduce the RBF, secondary to an increase in intrarenal pressure and, consequently, a decrease in p02.…”

Section: Discussionmentioning

confidence: 88%

Hypoperfusion in the Renal outer Medulla after Injection of Contrast Media in Rats

1999

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Section: Discussionmentioning

confidence: 88%

Hypoperfusion in the Renal outer Medulla after Injection of Contrast Media in Rats

1999

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“…), which leads to an increase in tubular pressure (Ueda et al . ). The tubules become distended, which compresses the blood vessels because of the rather tough renal capsule.…”

Section: Discussionmentioning

confidence: 97%

Early effects of an x‐ray contrast medium on renal T₂*/T₂MRI as compared to short‐term hyperoxia, hypoxia and aortic occlusion in rats

et al. 2013

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“…Secondly, CM might cause direct renal vasoconstriction, which is probably caused by the disturbances in several vasoactive mediator systems, e.g. Thus, other mechanisms are proposed: as hyperosmolar compounds, iopamidol-370 acts as an osmotic diuretic, freely filtered by the glomeruli and poorly absorbed by the renal tubule; the CM with high concentration causes a pronounced osmotic diuresis that distends the tubules and collecting ducts, leading to renal swelling and an increase in intra-renal venous pressure (29); the passive compression of the vessels arising from renal swelling could contribute to the decreased outer medullary RBF; also, the stasis-state of blood cells in the medullary vessels (30,31) partially caused by increased intra-renal venous pressure contributes to the delayed decrease in outer medullary perfusion. This can well explain the short-term vasoconstriction of most vascular beds, but seems to make no sense for the clarification of longer-term hypoperfusion, since the hemodynamic effects of these vasoactive substances are transient.…”

Section: Hemodynamic Effects Of Iodinated CMmentioning

confidence: 99%

The serial effect of iodinated contrast media on renal hemodynamics and oxygenation as evaluated by ASL and BOLD MRI

Zhang

Wang

Yang

et al. 2012

Contrast Media & Molecular

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Contrast-induced nephropathy is a prevalent cause of renal failure, and the mechanisms underlying this injury are not fully understood. We utilized noninvasive functional MRI in order to determine the serial effect of a single administration of iodinated contrast media (CM) on renal hemodynamics and oxygenation. Fifteen rabbits were randomized to receive an intravenous injection of CM (i.e. iopamidol-370; 6 ml kg(-1) body weight) or an equivalent amount of 0.9% saline. Both arterial spin-labeling and blood oxygen level-dependent imaging sequences were performed at 24 h before and at intervals of 1, 24, 48 and 72 h after injection to obtain serial renal blood flow (RBF) and relative spin-spin relaxation rate (R(2)*). Results showed that, in the iopamidol group, the mean cortical RBF decreased at 1 h (p = 0.04 vs baseline), reached its minimum at 24 h (p = 0.01) and gradually returned to baseline by 48 h (p = nonsignificant, NS). The outer medullary RBF decreased to its minimum by 24 h (p = 0.00) and remained less than baseline until 72 h. R(2)* in inner stripes was dramatically increased at 1 h (p = 0.00), remained elevated at 24 h (p = 0.05), but returned to baseline by 48 h (p = NS). R(2)* values within the cortex and outer stripes and inner medulla were slightly increased, but the changes did not reach a statistical significance (p = NS). Saline did not produce positive change in either RBF or R(2)* within different compartments of the kidney. We conclude that iopamidol is associated with a relatively longer-term hypoperfusion in whole kidney and decreased oxygen level in the inner stripes of the outer medulla.

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Effect of Intravenous Contrast Media on Proximal and Distal Tubular Hydrostatic Pressure in the Rat Kidney

Cited by 45 publications

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Hypoperfusion in the Renal outer Medulla after Injection of Contrast Media in Rats

Hypoperfusion in the Renal outer Medulla after Injection of Contrast Media in Rats

Early effects of an x‐ray contrast medium on renal T₂*/T₂MRI as compared to short‐term hyperoxia, hypoxia and aortic occlusion in rats

The serial effect of iodinated contrast media on renal hemodynamics and oxygenation as evaluated by ASL and BOLD MRI

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Effect of Intravenous Contrast Media on Proximal and Distal Tubular Hydrostatic Pressure in the Rat Kidney

Cited by 45 publications

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Hypoperfusion in the Renal outer Medulla after Injection of Contrast Media in Rats

Hypoperfusion in the Renal outer Medulla after Injection of Contrast Media in Rats

Early effects of an x‐ray contrast medium on renal T2*/T2MRI as compared to short‐term hyperoxia, hypoxia and aortic occlusion in rats

The serial effect of iodinated contrast media on renal hemodynamics and oxygenation as evaluated by ASL and BOLD MRI

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Early effects of an x‐ray contrast medium on renal T₂*/T₂MRI as compared to short‐term hyperoxia, hypoxia and aortic occlusion in rats