Effect of Intravenous Gadolinium-DTPA on Diffusion-Weighted Magnetic Resonance Images for Evaluation of Focal Hepatic Lesions

Chiu, Fang-Ying; Jao, Jo-Chi; Chen, Chiao‐Yun; Liu, Gin-Chung; Jaw, Twei-Shiun; Chiou, Yen-Yu; Hsu, Feng-O; Hsu, Jui‐Sheng

doi:10.1097/01.rct.0000157472.98277.5c

Cited by 64 publications

(51 citation statements)

References 22 publications

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“…Although a previous study demonstrated the feasibility of enhanced DWI in liver MRI using gadopentetate dimeglumine (Gd-DTPA) [15], the effects of Gd-EOB-DTPA on DWI or the measured ADC have not been examined. Unlike extracellular contrast agents such as Gd-DTPA, approximately 50% of the injected dose of Gd-EOB-DTPA is specifically taken up into hepatocytes [12,14,16].…”

Section: Introductionmentioning

confidence: 99%

Diffusion-weighted MR imaging of liver on 3.0-Tesla system: effect of intravenous administration of gadoxetic acid disodium

et al. 2009

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Section: Introductionmentioning

confidence: 99%

Diffusion-weighted MR imaging of liver on 3.0-Tesla system: effect of intravenous administration of gadoxetic acid disodium

et al. 2009

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“…On the postmortem T1WI, the unwashed contrast was still observed, but the existence of contrast agent did not affect the postmortem ADC value in this study, because research has shown that the magnetic susceptibility of contrast medium should not influence the ADC value (34,35).…”

Section: Discussionmentioning

confidence: 79%

Diffusion‐weighted MRI of hepatic tumor in rats: Comparison between in vivo and postmortem imaging acquisitions

Sun

Wang

Chen

et al. 2009

Magnetic Resonance Imaging

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Purpose:To determine the feasibility of in vivo diffusionweighted imaging (DWI) to distinguish between normal liver, viable tumor and necrosis compared to postmortem DWI in a rat model with vascular-targeting treatment. Materials and Methods:Fifteen rats with liver implantation of 30 rhabdomyosarcomas were treated with combretastatin A-4-phosphate (CA4P) at 10 mg/kg. Two days after treatment, T2-weighted imaging, precontrast T1-weighted imaging, postcontrast T1-weighted imaging, and DWI were performed in vivo and postmortem with a 1.5T scanner. Apparent diffusion coefficients (ADCs) calculated from DWIs with b values of 0, 50, and 100 seconds/mm 2 (ADC low ), 500, 750, and 1000 seconds/mm 2 (ADC high ), 0, 500, and 1000 seconds/mm 2 (ADC 3b ), and 0 -1000 seconds/mm 2 (ADC 10b ) for tumor, liver, therapeutic necrosis, and phantoms were compared and validated with ex vivo microangiographic and histopathologic findings.Results: Except ADC low between tumor and necrosis, in vivo ADCs successfully differentiated liver, viable tumor, and necrosis (P Ͻ 0.05). Compared to in vivo outcomes, postmortem ADCs significantly dropped in tumor and liver (P Ͻ 0.05) except ADC high of tumor, but not in necrosis and phantoms. Compared to ADC low , ADC high was less affected by vital status. Conclusion:Advantageous over postmortem DWI, in vivo DWI provides a noninvasive easy-performing tool for distinguishing between liver, viable tumor, and necrosis. ADC low and ADC high better reflect tissue perfusion and water diffusion, respectively.

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“…Some studies have indicated that without reaching statistical significance, Gd-EOB-DTPA can influence DWI and T2-weighted images by causing higher magnetic susceptibility and T2 shortening [23,24]. In general, the DHBP with Gd-EOB-DTPA is acquired about 20 min after contrast administration, because at this time normal hepatocytes reach maximum signal intensity [25].…”

Section: Discussionmentioning

confidence: 99%

Does gadoxetate disodium affect MRE measurements in the delayed hepatobiliary phase?

et al. 2018

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Objectives To assess if the administration of gadoxetate disodium (Gd-EOB-DTPA) significantly affects hepatic magnetic resonance elastography (MRE) measurements in the delayed hepatobiliary phase (DHBP). Methods A total of 47 patients (15 females, 32 males; age range 23-78 years, mean 54.28 years) were assigned to standard hepatic magnetic resonance imaging (MRI) with application of Gd-EOB-DTPA and hepatic MRE. MRE was performed before injection of Gd-EOB-DTPA and after 40-50 min in the DHBP. Liver stiffness values were obtained before and after contrast media application and differences between pre-and post-Gd-EOB-DTPA values were evaluated using a Bland-Altman plot and the Mann-Whitney-Wilcoxon test. In addition, the data were compared with regard to the resulting fibrosis classification. Results Mean hepatic stiffness for pre-Gd-EOB-DTPA measurements was 4.01 kPa and post-Gd-EOB-DTPA measurements yielded 3.95 kPa. We found a highly significant individual correlation between pre-and post-Gd-EOB-DTPA stiffness values (Pearson correlation coefficient of r = 0.95 (p < 0.001) with no significant difference between the two measurements (p =0.49)). Bland-Altman plot did not show a systematic effect for the difference between pre-and post-stiffness measurements (mean difference: 0.06 kPa, SD 0.81). Regarding the classification of fibrosis stages, the overall agreement was 87.23% and the intraclass correlation coefficient was 96.4%, indicating excellent agreement. Conclusions Administration of Gd-EOB-DTPA does not significantly influence MRE stiffness measurements of the liver in the DHBP. Therefore, MRE can be performed in the DHBP. Key Points • MRE of the liver can reliably be performed in the delayed hepatobiliary phase.• Gd-EOB-DTPA does not significantly influence MRE stiffness measurements of the liver.• MRE performed in the delayed hepatobiliary-phase is reasonable in patients with reduced liver function.

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Effect of Intravenous Gadolinium-DTPA on Diffusion-Weighted Magnetic Resonance Images for Evaluation of Focal Hepatic Lesions

Abstract: There was no significant difference before and after administration of contrast agent in the SNR or CNR of DWI. This indicates the feasibility of postcontrast DWI as a substitute for an unsuccessful precontrast-enhanced study in clinical practice.

Cited by 64 publications

References 22 publications

Diffusion-weighted MR imaging of liver on 3.0-Tesla system: effect of intravenous administration of gadoxetic acid disodium

Diffusion-weighted MR imaging of liver on 3.0-Tesla system: effect of intravenous administration of gadoxetic acid disodium

Diffusion‐weighted MRI of hepatic tumor in rats: Comparison between in vivo and postmortem imaging acquisitions

Does gadoxetate disodium affect MRE measurements in the delayed hepatobiliary phase?

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