Effect of Intravenous Injection of Oxidized Methyl Esters of Unsaturated Fatty Acids on Chick Encephalomalacia.

Nishida, Toshiro; Tsuchiyama, Hldeo; Inoue, Mayuri; Kummerow, Fred A.

doi:10.3181/00379727-105-26093

Cited by 93 publications

(3 citation statements)

References 5 publications

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“…Because a substantial portion of the dietary LA in industrialized populations is heated prior to consumption, modern populations have substantially increased intakes of both LA and preformed LA peroxidation products. Consumption of heated oils rich in LA without adequate vitamin E [22,23], or intravenous administration of HPODEs [24], can produce cerebellar necrosis and ataxia in chicks, suggesting that dietary OXLAMs might potentially have adverse effects in CNS tissues. However, it is not yet known whether eating nonoxidized or heated vegetable oils has biochemical consequences in mammalian brain tissues.…”

Section: Discussionmentioning

confidence: 99%

“…OXLAMs and 4-HNE have been mechanistically linked to several pathological conditions including cardiovascular disease [15], steatohepatitis [16,17], neurodegenerative diseases [18], and chronic pain [6,19,20], reviewed in [3,15,21]. Consumption of heated vegetable oils rich in LA [22,23], or intravenous administration of HpODEs [24], produces cerebellar necrosis and ataxia in chicks without damaging the cerebral cortex, indicating that OXLAMs could potentially have brainregion specific neurotoxic effects in some species. Plausible mechanisms exist whereby high exposure to OXLAMs could have neurotoxic effects in humans, including endothelial cell activation [25], generalized lipid and membrane peroxidation [26,27], mitochondrial dysfunction [28], and microglial activation [29–31].…”

Section: Introductionmentioning

confidence: 99%

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Effects of diets enriched in linoleic acid and its peroxidation products on brain fatty acids, oxylipins, and aldehydes in mice

Ramsden

Hennebelle

Schuster

et al. 2018

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biolog

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A B S T R A C TBackground: Linoleic acid (LA) is abundant in modern industrialized diets. Oxidized LA metabolites (OXLAMs) and reactive aldehydes, such as 4-hydroxy-2-nonenal (4-HNE), are present in heated vegetable oils and can be endogenously synthesized following consumption of dietary LA. OXLAMs have been implicated in cerebellar degeneration in chicks; 4-HNE is linked to neurodegenerative conditions in mammals. It unknown whether increasing dietary LA or OXLAMs alters the levels of oxidized fatty acids (oxylipins), precursor fatty acids, or 4-HNE in mammalian brain. Objectives: To determine the effects of increases in dietary OXLAMs and dietary LA, on levels of fatty acids, oxylipins, and 4-HNE in mouse brain tissues. Methods: Mice (n = 8 per group) were fed one of three controlled diets for 8 weeks: (1) a low LA diet, (2) a high LA diet, or (3) the low LA diet with added OXLAMs. Brain fatty acids, oxylipins, and 4-HNE were quantified in mouse cerebellum and cerebral cortex by gas chromatography-flame ionization detection, liquid chromatography-tandem mass spectrometry, and immunoblot, respectively. Results: Increasing dietary LA significantly increased omega-6 fatty acids, decreased omega-3 fatty acids, and increased OXLAMs in brain. Dietary OXLAMs had minimal effect on oxidized lipids but did decrease both omega-6 and omega-3 fatty acids. Neither dietary LA nor OXLAMs altered 4-HNE levels. Conclusion: Brain fatty acids are modulated by both dietary LA and OXLAMs, while brain OXLAMs are regulated by endogenous synthesis from LA, rather than incorporation of preformed OXLAMs.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of diets enriched in linoleic acid and its peroxidation products on brain fatty acids, oxylipins, and aldehydes in mice

Ramsden

Hennebelle

Schuster

et al. 2018

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biolog

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“…Ever since it was established that lipid peroxides had mutagenic effects on cells (Wyss, Stone & Clark, 1947;Dickey, Cleland & Lotz, 1949;Ross, 1950;Loveless, 1951), there have been numerous reports on the cytotoxicity of these compounds. Fatty acid peroxides exert lethal effects when administered parenterally to mice, rabbits and chickens (Horgan, Philpot, Porter & Roodyn, 1957;Findlay, Draper & Bergan, 1970;Nishida, Tsuchiyama, Inoue & Kummerow, 1960), and to cause intense pain when injected subcutaneously into human subjects (Ferreira, 1972). At a cellular level, lipid peroxides produce lesions in the mucosal lining of the lung and small intestine (Cortesi & Privett, 1972;Olcott & Dolev, 1963) and induce aggregation of erythrocytes and blood platelets (Tsen & Collier, 1960;Mickel & Hörbar, 1974).…”

Section: Introductionmentioning

confidence: 99%

Toxicity of exogenous fatty acid peroxides towards spermatozoa

Jones¹,

Mann²

1977

Reproduction

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The toxicity of unsaturated fatty acids towards spermatozoa was shown to be directly related to their degree of peroxidation. The toxicity was manifested by an immediate arrest of motility and irreversible loss of respiratory and fructolytic activity. Repeated washing of spermatozoa, or the addition of fructose, lactate, or ATP, failed to restore these functions. The structural damage incurred as a result of the fatty acid peroxides was particularly evident in the acrosomal region. Partial protection from the adverse effects of these peroxides was provided by prior treatment of spermatozoa with dialysed egg yolk or milk, but tocopherol, albumin and mercapto-ethanol were ineffective. It is suggested that lipid peroxides or their degradation products, whether introduced exogenously or derived from the peroxidation of endogenous phospholipids in semen, constitute a potential hazard to the functional integrity of spermatozoa.

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Introduction—a perspective

Wertheimer

1965

Comprehensive Physiology

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Effect of Intravenous Injection of Oxidized Methyl Esters of Unsaturated Fatty Acids on Chick Encephalomalacia.

Cited by 93 publications

References 5 publications

Effects of diets enriched in linoleic acid and its peroxidation products on brain fatty acids, oxylipins, and aldehydes in mice

Effects of diets enriched in linoleic acid and its peroxidation products on brain fatty acids, oxylipins, and aldehydes in mice

Toxicity of exogenous fatty acid peroxides towards spermatozoa

Introduction—a perspective

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