Effect of intraventricular injection of histamine on the pinna reflex in mice.

Kamei, Chiaki; Dabasaki, Tatsuro; Tasaka, Kenjí

doi:10.1254/jjp.35.193

Cited by 6 publications

(1 citation statement)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mice were habituated to the environment for 60 minutes before the first amphetamine treatment (Supplementary Figure 3A). They were then briefly immobilized and treated ICV with HA (20 μg in 1 μl sterile saline; (Kalivas, 1982; Kamei et al, 1983, 1984; Onodera and Ogura, 1981)) or saline and then immediately injected IP with amphetamine (8.5 mg/kg). Stereotypical behaviors were measured at intervals over 90 minutes by a trained observer blind to animal genotype and drug treatment.…”

Section: Methodsmentioning

confidence: 99%

Histidine Decarboxylase Deficiency Causes Tourette Syndrome: Parallel Findings in Humans and Mice

Baldan

Williams

Gallezot

et al. 2014

Neuron

218

228

View full text Add to dashboard Cite

Tourette syndrome (TS) is characterized by tics, sensorimotor gating deficiencies, and abnormalities of cortico-basal ganglia circuits. A mutation in histidine decarboxylase (Hdc), the key enzyme for the biosynthesis of histamine (HA), has been implicated as a rare genetic cause. Hdc knockout mice exhibited potentiated tic-like stereotypies, recapitulating core phenomenology of TS; these were mitigated by the dopamine D2 antagonist haloperidol, a proven pharmacotherapy, and by HA infusion into the brain. Prepulse inhibition was impaired in both mice and humans carrying Hdc mutations. HA infusion reduced striatal dopamine (DA) levels; in Hdc knockout mice, striatal DA was increased and the DA-regulated immediate early gene Fos was upregulated. Dopamine D2/D3 receptor binding was altered both in mice and in humans carrying the Hdc mutation. These data confirm HDC deficiency as a rare cause of TS and identify histamine-dopamine interactions in the basal ganglia as an important locus of pathology.

show abstract

Section: Methodsmentioning

confidence: 99%