Effect of Intravitreal Injection of Bevacizumab on Optic Nerve Head Leakage and Retinal Ganglion Cell Survival in a Mouse Model of Optic Nerve Crush

Abstract

Bevacizumab treatment following ONC induction exerts a protective effect, manifested by reduced optic nerve head edema. The underlying mechanism probably involves a lesser interruption of axonal transport. Reduced expression of antioxidative and ischemic genes may contribute to RGC preservation.

Efficacy of Intravitreal Injections of Antivascular Endothelial Growth Factor Agents in a Rat Model of Anterior Ischemic Optic Neuropathy

“…18 However, anti-VEGF agents were reported to contribute to RGC preservation in a mouse model of ON crush. 19 In an animal laser-induced choroidal neovascularization, no significant reduction was found in retinal function, the retinal level of mRNA for ganglion cell-specific genes, and RGC axon count after blockage of VEGF for 7 months in transgenic mice. 20 To the best of our knowledge, anti-VEGF agents have never been evaluated in a rat model of anterior ischemic optic neuropathy (rAION).…”

7,8-Dihydroxyflavone Inhibits VEGF-Induced in Vitro Angiogenesis of RF/6A Cells via the Blocking of VEGFR2 Signaling Pathway

“…It should be noted that these retinal vascular disorders are always accompanied by neuronal damage [11]. Although anti-VEGF treatments have been extensively administered for neovascular eye diseases [12], they are likely to aggravate this neuronal injury and thus deteriorate visual function [13]. To solve this dilemma, a treatment that can protect neurons and simultaneously inhibit angiogenesis is urgently needed.…”

Translational Preclinical Research may Lead to Improved Medical Management of Non-Arteritic Anterior Ischemic Optic Neuropathy

“…Clinical findings on the benefit of bevacizumab were supported in a murine model of ONC, showing that the drug preserved the integrity of the microvasculature (56). This apparently prevented post-ONC ischemia from spreading from the site of injury to the immediate retrobulbar portion of the nerve.…”