Effect of inulin in the treatment of irritable bowel syndrome with constipation (Review)

Abstract

At present, irritable bowel syndrome (IBS) is a common medical problem all over the world that implies considerable social burden and high costs. Considering the different pathophysiological pathways, unitary management for IBS is not possible. Of the therapeutic approaches that have been proposed so far, only a few have been demonstrated to have beneficial effects in IBS patients. The implication of gut microbiota in IBS is obvious, similarly to the therapeutic effect of pro-/prebiotics, which is reflected by the latest publications. The intake of inulin seems to regulate the bowel peristalsis and colonic transit, the consistency and frequency of the stools, as it changes the composition of gut microbiota. The beneficial effect of inulin in patients with IBS-constipation form (IBS-C) is obvious, but still, more randomized controlled clinical trials involving large samples of patients are needed in order to provide more evidence. Contents

Shaping the Physicochemical, Functional, Microbiological and Sensory Properties of Yoghurts Using Plant Additives

“…The combination of probiotics and prebiotics, otherwise known as symbiotics, in yoghurts is desirable because it contributes to the prevention of many diseases [ 172 , 173 ]. Moreover, Bărboi et al [ 174 ] demonstrated that inulin changes the composition of the gastrointestinal microflora by regulating the passage of the large intestine among people with intestinal disorders. IBS is a dysfunction caused by dysbiosis of the intestinal microflora that affects people of all ages.…”

The problem of dehydration in pediatrics

“…Крім того, бродіння інуліну призводить до збільшення коротколанцюгових жирних кислот і вироблення молочної кислоти, тим самим знижується рН товстої кишки, що може додатково контролювати ріст патогенних бактерій і сприяти захисним властивостям інуліну [30]. На цей час також накопичені дані про вплив інуліну на регуляцію перистальтики й транзиту кишечника, консистенцію і частоту випорожнень, склад і активність мікробіоти кишечника, модуляцію імунної відповіді й засвоєння мінеральних речовин [31]. На сьогодні в клінічній практиці часто застосовуються комбіновані препарати, що містять пробіотичні штами в поєднанні з пребіотичними речовинами (симбіотики).…”

Radiological Approach to Diagnosis of Peribiliary Lesions

“…7 On USG, they appear as hypoechoic, hyperechoic or mixed heterogenic echoic structures, depending on the number and size of the cysts and the degree of fibrosis and often show multiple comet tail sign. 8 On CT, they are seen as irregularly marginated, hypoattenuating lesions with no contrast enhancement. These lesions appear hypointense on T1WI and hyperintense on T2WI, compared to the surrounding liver parenchyma (Figure 1).…”

“…These lesions appear hypointense on T1WI and hyperintense on T2WI, compared to the surrounding liver parenchyma (Figure 1). 8 The characteristic imaging findings help in the diagnosis; otherwise, followup imaging or histological confirmation is necessary to distinguish them from liver metastases, microabscesses, diffuse primary hepatocellular carcinoma, biliary cysts and Caroli's disease. 8…”