Effect of iodinated water soluble contrast media on urinary protein assays.

Multiple myeloma in 16 cats: a retrospective study

“…The SSA test is more sensitive to globulins and thus can be positive when the dipstick is negative, but it is nonspecific in that it detects albumin, globulins, Bence-Jones protein, polypeptides, and proteases. 60 False-positive SSA results may occur with penicillin and its derivatives, tolbutamide or sulfisoxazole metabolites, or certain roentgenographic contrast media in the urine. 60 In people, it has been reported that false-positive results for Bence-Jones proteins, assayed by heat precipitation, may be due to an excess of polyclonal light chains in patients with connective tissue diseases, chronic renal failure, or nonplasmacytic malignancies.…”

“…60 False-positive SSA results may occur with penicillin and its derivatives, tolbutamide or sulfisoxazole metabolites, or certain roentgenographic contrast media in the urine. 60 In people, it has been reported that false-positive results for Bence-Jones proteins, assayed by heat precipitation, may be due to an excess of polyclonal light chains in patients with connective tissue diseases, chronic renal failure, or nonplasmacytic malignancies. 61 For these reasons, protein electrophoresis of concentrated urine is the preferred technique for detection of monoclonal light chains in urine.…”

Contrast media: interactions with other drugs and clinical tests

“…Therefore, clotting tests should be avoided for 6 h or more after injection of contrast media [15]. Iodinated contrast media in the urine may also interfere with some of the protein assay techniques leading to false-positive results [26]. Care must be exercised in interpreting tests for proteinuria for 24-h post-contrast media injection.…”

A Brief Comment On The Treatment Of Internal Hemorrhoids By Rubber Band Ligation Combined With Sclerotherapy

“…SSA is mainly used for the detection of myeloma kidney. The SSA has false positive results when an iodinated contrast agent is used [9] and an abnormal SSA result should be confirmed with a quantitative test.…”