Effect of iodine supplementation on thyroid and testicular morphology and function in euthyroid rats

Shoyinka, S. V. O.; Obidike, Ikechukwu Reginald; Ndumnego, Okechukwu Chinazo

doi:10.1007/s11259-008-9065-7

Cited by 7 publications

(1 citation statement)

References 14 publications

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“…The whole brain (cerebrum + cerebellum) and cerebellar mass were obtained. From this data, the Organosomatic Index (organ mass / the whole animal mass * 100) was calculated for the brain and cerebellum by applying the method described by Shoyinka et al 2008.…”

Section: Morphometry Of Gross Brain Parametersmentioning

confidence: 99%

The modification of the ketogenic diet mitigates its stunting effects in rodents

Liśkiewicz

Kasprowska-Liśkiewicz

Sługocka

et al. 2018

Appl. Physiol. Nutr. Metab.

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The high-fat and low-carbohydrate ketogenic diet (HFKD) is extensively studied within the fields of numerous diseases, including cancer and neurological disorders. Since most studies incorporate animal models, ensuring the quality of ketogenic rodent diets is important, both in the context of laboratory animal welfare as well as for the accuracy of the obtained results. In this study we implemented a modification to a commonly used ketogenic rodent chow by replacing non-resorbable cellulose with wheat bran. We assessed the effects of month-long treatment with either the unmodified or the modified HFKD on the growth and development of young male rats. Daily body weight, functional performance, and brain morphometric parameters were assessed to evaluate the influence of both applied diets on rodent development. Our results revealed that the unmodified ketogenic chow induced strong side effects that included weakness, emaciation, and brain undergrowth concomitant to growth inhibition. However, application of the ketogenic chow supplemented with wheat bran suppressed these adverse side effects, which was associated with the restoration of insulin-like growth factor 1 and a decrease in corticosterone levels. We have also shown that the advantageous results of the modified HFKD are not species- or sex-specific. Our data indicate that the proposed HFKD modification even allows for its application in young animals, without causing detrimental side effects.

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Section: Morphometry Of Gross Brain Parametersmentioning

confidence: 99%

The modification of the ketogenic diet mitigates its stunting effects in rodents

Liśkiewicz

Kasprowska-Liśkiewicz

Sługocka

et al. 2018

Appl. Physiol. Nutr. Metab.

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Effect of Excess Iodine on Oxidative Stress Markers, Steroidogenic—Enzyme Activities, Testicular Morphology, and Functions in Adult Male Rats

Chakraborty

Mandal

Mondal

et al. 2015

Biol Trace Elem Res

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Improper iodine intake is a major concern in public health. Chronic intake of low iodine affects gonadal functions of man and animals; however, such effects of excess iodine in male reproduction, specially on testicular morphology, testicular steroidogenic enzyme activities, sperm morphology, sperm viability, and sperm count including male hormonal profiles in reference to iodine status and thyroid hormone profiles are yet to be explored. With this background, adult male rats of 120 ± 10 gm Bw of 90 ± 5 days were divided broadly in two groups depending on the duration of the treatment for 30 and 60 days, respectively. Both the groups consisted of control animals. Excess iodine (100EI), i.e., 100 times more than its recommended level but within its tolerable ranges, was administered through gavage regularly to the first group of experimental animals for 30 and 60 days, respectively, and excessive iodine (500EI), i.e., 500 times more than its recommended level and above tolerable range in the same way and for the same durations, was administered to the other group of experimental animals. Overall results revealed that regular consumption of iodine in excess impairs reproductive functions in adult male rats depending on the dose and duration of its exposure through different mechanisms. Excess iodine accumulates in the testis which results in generation of reactive oxygen species (ROS) as evidenced by higher lipid peroxidation level as well as an imbalance in the pro-/antioxidant status inhibiting the activity of ∆(5) 3β- hydroxysteroid dehydrogenase (HSD) and 17β-HSD resulting to reduced synthesis of testosterone that causes structural and functional changes of the testis. Secondly, persistent generation of ROS in testis as a result of prolonged excess iodine exposure affects hypothalamo-pituitary-adrenal axis that stimulates synthesis and secretion of corticosterone which inhibits LH release that downregulates testosterone synthesis causing further testicular disruption. Thirdly, excess iodine when administered above its tolerable ranges for prolonged duration acts on thyroid itself developing a state of biochemical hypothyroidism (as evident by low T3) which further potentiate the disrupting effect of excess iodine on male gonads by reducing circulating testosterone level.

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Protein value and health aspects of the seaweeds Saccharina latissima and Palmaria palmata evaluated with mink as model for monogastric animals

Krogdahl

Jaramillo-Torres

Ahlstrøm

et al. 2021

Animal Feed Science and Technology

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Effect of iodine supplementation on thyroid and testicular morphology and function in euthyroid rats

Cited by 7 publications

References 14 publications

The modification of the ketogenic diet mitigates its stunting effects in rodents

The modification of the ketogenic diet mitigates its stunting effects in rodents

Effect of Excess Iodine on Oxidative Stress Markers, Steroidogenic—Enzyme Activities, Testicular Morphology, and Functions in Adult Male Rats

Protein value and health aspects of the seaweeds Saccharina latissima and Palmaria palmata evaluated with mink as model for monogastric animals

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