Effect of Iodine Supplementation on Antioxidant Status of Normal and Alloxan Monohydrate in Toxicated Rats

Agbor, Gabriel A.; Taga, Ibrahim; Nguindex, Danielle R.; Zaidi, Mohsin Abbas; Lehman, L; Altosaar, Illimar; Ngogang, Jeanne

doi:10.3923/ijp.2011.726.731

Cited by 9 publications

(5 citation statements)

References 27 publications

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“…(Yildirim et al, 2006) have reported an increase in AAT and ALAT enzyme activities in gills, liver and kidney and have proposed that elevated enzyme activity is with the intension to increase the role of proteins for energy production during stress. Similar elevation in aminotransferases also have been reported by peer researchers (Agbor et al, 2011;Gabriel et al, 2012;Velmurugan et al, 2008), which is due to the increased utilization of amino acids for energy synthesis as a consequence of this, fish suffers from toxic stress and energy crisis.…”

Section: Resultssupporting

confidence: 77%

Enzymatic changes during lethal and sublethal exposures of Glyphosate (41% SL) on freshwater fish Cirrhinus mrigala

Rajeswari¹,

Sunita²

2021

Int.J.Zool.Appl.Biosci

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The lethal and sublethal effect of the Glyphosate (41% SL) on certain enzymes in tissue such as AAT (Aspartate Amino Transferase), ALAT (Alanine Amino Transferase), LDH (Lactate Dehydrogenase) and ACP (Acid Phosphatase) of the freshwater fish, Cirrhinus mrigala during and after the cessation of the exposure were observed. Ten fish were exposed chronically to lethal and sublethal concentrations for a period of 4 days were sacrificed and tissues such as brain, gill, liver, kidney and muscle were analysed for biochemical parameters and remaining five fish were maintained in clean well water for a period of seven days without test substance being spilled in the water and its tissues were collected after reversal period for biochemical analysis. Marked changes were observed in the biochemical parameters of the fish exposed and after the cessation of the exposure

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Section: Resultssupporting

confidence: 77%

Enzymatic changes during lethal and sublethal exposures of Glyphosate (41% SL) on freshwater fish Cirrhinus mrigala

Rajeswari¹,

Sunita²

2021

Int.J.Zool.Appl.Biosci

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“…Iodine is one of the exogenous scavengers of oxidative molecules produced during various metabolic processes [ 38 , 39 ]. Compared to the first two trimesters of pregnancy, women in the third trimester have a higher metabolic rate and are predisposed to greater iodine loss due to increased renal filtration [ 40 , 41 ].…”

Section: Discussionmentioning

confidence: 99%

Iodine deficiency in pregnancy along a concentration gradient is associated with increased severity of preeclampsia in rural Eastern Cape, South Africa

Businge

Longo-Mbenza

Kengne

2022

BMC Pregnancy Childbirth

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Background Preeclampsia is a leading cause of maternal mortality and morbidity in South Africa. Iodine deficiency in pregnancy, which is amenable to correction through iodine supplementation, has been reported to increase the risk of preeclampsia. However, the association of iodine nutrition status with preeclampsia in South Africa has not been studied. Methods We enrolled 51 randomly selected normotensive pregnant controls at term together with 51 consecutively selected cases of preeclampsia and 51 cases of severe preeclampsia/eclampsia, all in the third trimester, from Mthatha Regional and Nelson Mandela Academic Hospital in the Eastern Cape Province. Urinary iodine concentration (UIC), serum thyroid-stimulating hormone (TSH), triiodothyronine (FT3), thyroxine (FT4) and thyroglobulin (Tg) levels were compared between cases and controls. Results The respective chronological and gestational ages at enrolment for normotensive, preeclampsia and severe preeclampsia/eclampsia participants were: age 23, 24 and 19 years (p = 0.001), and gestational age 38, 34, and 35 weeks (p < 0.001). The median gravidity was 1 for all three groups. The median UIC, FT4, FT3 revealed a decreasing and Tg a rising trend with the severity of preeclampsia (p < 0.05). TSH had a non-significant rising trend (p > 0.05). The respective median values for normotensive, preeclampsia and severe preeclampsia/eclampsia participants were UIC 217.1, 127.7, and 98.8 μg/L; FT4 14.2, 13.7, and 12. pmol/L; FT3 4.8, 4.4, and 4.0 pmol//L; Tg 19.4, 21.4, and 32. Nine microgram per liter; TSH 2.3, 2.3, and 2.5 mIU/L. UIC < 100 μg/L, Tg > 16 μg/L and FT4 < 11.3 pmol/L were independent predictors of preeclampsia/eclampsia syndrome. Conclusion Women with severe preeclampsia/eclampsia had significantly low UIC and high Tg, suggesting protracted inadequate iodine intake. Inadequate iodine intake during pregnancy severe enough to cause elevated Tg and FT4 deficiency was associated with an increased risk of severe preeclampsia/eclampsia.

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“…However, a study in the International Journal of Pharmacology found that iodine supplements functioned as antioxidants by increasing antioxidant enzyme activity in intoxicated rats. Results showed that oxidative stress in the rats, a prime factor in risk for cardiovascular disease, was neutralized by the supplementation of iodine in their diets (Agbor et al, 2011). The rats who received iodine supplements, in comparison to the control groups with no intoxication, had an increased antioxidant concentration of 89.73 mol/L while the control group had an antioxidant level of 60.43 mol/L.…”

Section: Iodine Incorporationmentioning

confidence: 97%

The Effect of Potassium Iodide Absorption on the Concentration of Antioxidants in Tomato Fruits

Kini

Flowers²

2021

J Stud Res

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Antioxidants are molecules found in fruits and vegetables that have the ability to fight substances in the human body that are detrimental to cells and genetic material. There is a high need for antioxidants, and the current method for boosting antioxidants is genetic modification, which is controversial in society; however, there is a lack of research concerning increasing antioxidant concentrations in plants in a natural manner. Thus, the efficacy of an iodine water drip can be called into question. Iodine has been proven to increase antioxidant enzymatic activity in animals and certain leafy vegetables. This paper will evaluate the effectiveness of an potassium iodide enriched water drip on the concentration of antioxidants in tomato plants. potassium iodide (KI) solution was created from diluting KI crystals into water, and the tomatoes were watered every day over a three month growth period. At the end of the allotted growth period, four tomatoes were plucked from each group—the potassium iodide group, and the control group that was watered regularly. In order to calculate the increase in concentration, each tomato was mashed with an Efferdent denture-cleansing tablet so as to measure the absorbance of each sample using the blue dye from the tablet. Once obtaining the absorbance, the concentrations were found using Beer’s law. Using a 2 sample T-test for the difference in antioxidants, the increase in antioxidants was found to be statistically significant.

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Effect of Iodine Supplementation on Antioxidant Status of Normal and Alloxan Monohydrate in Toxicated Rats

Cited by 9 publications

References 27 publications

Enzymatic changes during lethal and sublethal exposures of Glyphosate (41% SL) on freshwater fish Cirrhinus mrigala

Enzymatic changes during lethal and sublethal exposures of Glyphosate (41% SL) on freshwater fish Cirrhinus mrigala

Iodine deficiency in pregnancy along a concentration gradient is associated with increased severity of preeclampsia in rural Eastern Cape, South Africa

The Effect of Potassium Iodide Absorption on the Concentration of Antioxidants in Tomato Fruits

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