Effect of iron supplementation during early pregnancy on the development of gestational hypertension and pre-eclampsia

Jirakittidul, Preeyaporn; Sirichotiyakul, Supatra; Ruengorn, Chidchanok; Techatraisak, Kitirat; Wiriyasirivaj, Busaba

doi:10.1007/s00404-018-4821-6

Cited by 23 publications

(22 citation statements)

References 15 publications

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“…It was found that a high level of hemoglobin in women supplemented with iron was associated with an increase in the frequency of adverse effects, including preeclampsia [8,27]. In the study by Jirakittidul et al [45] iron supplementation before 16 pregnancy week was associated with a significant increase in the risk of hypertension de novo after the 20th week of pregnancy. Ziaei et al [46] found that the administration of iron at the beginning of the second trimester of pregnancy in women with a hemoglobin concentration of >13.2 g/dL increased the risk of pregnancy-induced hypertension.…”

Section: Discussionmentioning

confidence: 99%

Can Serum Iron Concentrations in Early Healthy Pregnancy Be Risk Marker of Pregnancy-Induced Hypertension?

2019

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The aim of this study was to assess the relationship between serum iron concentrations in early healthy pregnancy and the risk of pregnancy-induced hypertension. The data comes from our prospective cohort study in which we recruited healthy women in week 10–14 of single pregnancy. We examined a study group (n = 121) consisting of women subsequently developing pregnancy-induced hypertension and a control group (n = 363) of matched women remaining normotensive. We measured iron concentrations in the serum collected in 10–14 gestational week, using the ICP-MS technique (mass spectrometry with inductively coupled plasma). The odds ratios of the disease (95% confidence intervals) for iron concentrations were assessed in multivariate logistic regression. We found that the mean microelement concentration was lower in the case group compared to normotensive controls (p = 0.011). Women in the lowest quartile of iron (≤801.20 µg/L) had a 2.19-fold increase in pregnancy-induced hypertension risk compared with women in the highest quartile (>1211.75 µg/L) (odds ratio (OR) = 2.19; 95% CI: 1.24–3.88; p = 0.007). This result was sustained after adjusted for all the accepted confounders. Women in the higher Q2 quartile (801.20–982.33 µg/L) had a 17% lower risk, compared with those in the highest quartile (OR = 0.83; 95% CI: 0.65–2.32; p = 0.519).

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Section: Discussionmentioning

confidence: 99%

Can Serum Iron Concentrations in Early Healthy Pregnancy Be Risk Marker of Pregnancy-Induced Hypertension?

2019

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“…Iron takes part in the formation of reactive forms of oxygen and is responsible for development of insulin resistance and reduced insulin secretion by the pancreatic beta cells [11,12]. Current research indicates a possible link between iron excess and risk of preeclampsia, especially among women supplementing iron before 16 weeks of gestation with normal Hgb concentration (Hgb > 13.2 g/dL at the beginning of the second trimester) [13][14][15].…”

Section: Ironmentioning

confidence: 99%

Polish Society of Gynecologists and Obstetricians recommendations on supplementation in pregnancy

et al. 2020

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“…Inordinate supplementation, resulting from the simultaneous use of several multivitamin preparations, may also have a negative impact on the developing pregnancy, e.g., an increased risk of congenital defects in case of the excessive use of vitamin A [21]. Furthermore, it has recently been reported by numerous authors that unnecessary iron supplementation may contribute to negative pregnancy outcomes by increasing the risk of pregnancy-induced hypertension, pre-eclampsia or gestational diabetes mellitus [22][23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Micronutrients in Multiple Pregnancies—The Knowns and Unknowns: A Systematic Review

Zgliczyńska

Kosińska-Kaczyńska

2021

Nutrients

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Maternal diet and nutritional status are of key importance with regard to the short- and long-term health outcomes of both the mother and the fetus. Multiple pregnancies are a special phenomenon in the context of nutrition. The presence of more than one fetus may lead to increased metabolic requirements and a faster depletion of maternal macro- and micro- nutrient reserves than in a singleton pregnancy. The aim of this systematic review was to gather available knowledge on the supply and needs of mothers with multiple pregnancies in terms of micronutrients and the epidemiology of deficiencies in that population. It was constructed in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses Statement (PRISMA). The authors conducted a systematic literature search with the use of three databases: PubMed/MEDLINE, Scopus and Embase. The last search was run on the 18 October 2020 and identified 1379 articles. Finally, 12 articles and 1 series of publications met the inclusion criteria. Based on the retrieved studies, it may be concluded that women with multiple pregnancies might be at risk of vitamin D and iron deficiencies. With regard to other microelements, the evidence is either inconsistent, scarce or absent. Further in-depth prospective and population studies are necessary to determine if nutritional recommendations addressed to pregnant women require adjustments in cases of multiple gestations.

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Effect of iron supplementation during early pregnancy on the development of gestational hypertension and pre-eclampsia

Abstract: In our study population, iron supplementation before 16 weeks' GA was significantly associated with increased risk of developing de novo hypertension after 20 weeks' gestation.

Cited by 23 publications

References 15 publications

Can Serum Iron Concentrations in Early Healthy Pregnancy Be Risk Marker of Pregnancy-Induced Hypertension?

Can Serum Iron Concentrations in Early Healthy Pregnancy Be Risk Marker of Pregnancy-Induced Hypertension?

Polish Society of Gynecologists and Obstetricians recommendations on supplementation in pregnancy

Micronutrients in Multiple Pregnancies—The Knowns and Unknowns: A Systematic Review

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