Effect of Iron, Zinc, Vitamin E and Vitamin C Supplementation on Thyroid Hormones in Rats with Hypothyroidism

Abstract

Abstract:The aim of the study was to investigate the effect of Iron, Zinc, Vitamin C (Vit.C) and Vitamin E (Vit.E) supplementation on thyroid hormones in rats with hypothyroidism. Thirty six rats were divided into two main groups, the first main group (6 rats) was fed on basal diet only. The second main group (30 rat) were injected with 10 mg/kg/day Propylthiouracil (PTU) to induce hypothyroidism, was divided into 5 subgroups: including control positive group that fed on basal diet, and the other subgroups were fed on basal diet supplemented with 40 mg ferric sulphate/kg diet, 200 mg zinc carbonate /kg diet, 250 mg α-tocohperol acetate/kg/B.W. and 250 mg ascorbic acid/kg/B.W. respectively. Blood samples were collected from each rat and were centrifuged to obtain serum. PTU exposed rats showed hypothyroidism with significant (P<0.05) decline in serum FT3 and FT4 levels together with significant (P<0.05) increase in serum TSH level. The supplementation with Iron, Zinc, Vit.E or Vit.C significantly (P<0.05) increased the level of thyroid hormones (FT4 and FT3) and glutathione peroxidase, moreover, the level of TSH was significantly (P<0.05) decreased, compared with control positive group, might be due to their antioxidant properties. Significant improvement in lipid profile as well as liver and kidney functions were observed. It could be suggested that Vitamin C, Vitamin E, Zinc and Iron could be used as a suitable supplementation therapy for hypothyroidism patients.

Effect of Soybean, Virgin Coconut and Moringa oleifera Seed Oils on the Propylthiouracil Induced Hypothyroidism in Rats

“…The best thyroid functions were observed in rats fed on MOO compared to the other treated groups. The results of Rabeh and El-Ghandour (2016) and Rabeh (2017) indicated that thyroid hormones were dramatically reduced by PTU. Bhanja and Chainy (2010) reported that hypothyroidism causes oxidative stress in rats.…”

“…According to Siddalingaswamy et al (2011) and Pretha et al (2013), VCO ables to positively influence liver functions. Rabeh and El-Ghandour (2016) and Aisuodionoe et al (2018) reported that VCO improves metabolic parameters, antioxidant enzyme activities, reduces oxidative stress and lipid peroxidation in diabetes. Famurewa et al (2018) mentioned that beneficial effects of VCO on lipid profile, antioxidant hepatic defense system, and cardiovascular risk indices in rats.…”

The activity of curcumin combined with ZnCl₂ on streptozotocin-induced diabetic rats. An anti-diabetic, anti-hyperlipidemic study ‎

“…The level of serum glucose increased significantly (p≤0.05) in PC group (STZ-treated); and reduced significantly (p≤0.05) in CUR (100 & 200 mg/kg b.w) and CUR coupled with ZnCl 2 (15 mg/kg b.w) treated groups, concerning the PC. Histopathological investigations revealed that the diabetic liver had a high degree of hydropic degeneration accompanied by coagulative necrosis (Figure 2 Our study provided an advanced model and more information concerning using treatment mixtures and important measurements for the provided model of diabetes [32]. Oxidative stress plays an important role in the pathogenesis and etiology of diabetes [33].…”

Micronutrient Influence in Thyroid Function: A Review

“…47 O Zn tem um lugar importante entre os micronutrientes necessários para o metabolismo da tireoide, além do Se e do iodo. 48 Um estudo 49 mostrou que a deficiência de Zn está associada à diminuição dos níveis de secreção de hormônios da tireoide, afetando o metabolismo do corpo e a taxa metabólica de repouso. 48 Na conversão periférica de T 4 a T 3 regulada pelas deiodinases tipo I e II, a primeira é uma enzima dependente de Se, e é possível que a deiodinase tipo II seja uma proteína dependente de Zn, ou, então, que necessite desse mineral como cofator no processo de deiodinação.…”

“…48 Um estudo 49 mostrou que a deficiência de Zn está associada à diminuição dos níveis de secreção de hormônios da tireoide, afetando o metabolismo do corpo e a taxa metabólica de repouso. 48 Na conversão periférica de T 4 a T 3 regulada pelas deiodinases tipo I e II, a primeira é uma enzima dependente de Se, e é possível que a deiodinase tipo II seja uma proteína dependente de Zn, ou, então, que necessite desse mineral como cofator no processo de deiodinação. 50 O Zn ainda parece ser necessário para o receptor da T 3 adotar sua confirmação biologicamente ativa.…”