An experiment was conducted during 2020 on tomato variety Big Beef F1, planted in Haplic chromic luvi soil under drip irrigation with mulching and fertigation in an unheated greenhouse. The aim was to determine how the yield and quality of tomato were affected under full (100% ET c ) and deficit irrigation (60% ET c ) in interaction with four fertilizer rates (120% RDF, 100% RDF, 80% RDF, 0%). The total yield of tomato plants under full irrigation was 25.7% higher than the yield of the tomato plants under deficit irrigation. Full irrigation, in interaction with the fertilization rates 120 % and 100% RDF of NPK, maintained 30% higher yield of tomato than the yield of plants under reduced water supply with the same fertilization rates. The following parameters: total soluble solids, pH, reducing sugars, ascorbic acid content and titratable acidity were examined to assess the quality of tomato fruits. Except pH, all of the quality parameters of the tomato plants, subjected to moderate stress, due to a reduction in the irrigation rate, showed higher values than those of fully irrigated plants. The pH trend was reversed and the parameter had higher values at full irrigation. Analysis of variance (ANOVA) was performed to analyze the effect of irrigation and fertilization with different rates. The effect of fertilization on the yield and quality of tomato was less pronounced compared to the effect of irrigation.