Effect of ischemic cerebral volume changes on behavior

Lyden, Patrick D.; Lonzo, Lisa; Nunez, Sonia; Dockstader, Taylor; Mathieu-Costello, Odile; Zivin, Justin A.

doi:10.1016/s0166-4328(96)02269-3

Cited by 30 publications

(17 citation statements)

References 27 publications

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“…With brain ϭ 0.14 (estimated from Ref. 18 assuming that, for rat brain, 16% of volume is white matter and about 80% gray matter (19)) and Intralipid30% ϭ 0.6 (9), this partition coefficient was estimated to 0.23. Neglecting T 1 -relaxation effects, this would lead to a peak ratio of about 12.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Xenon‐129 MR imaging and spectroscopy of rat brain using arterial delivery of hyperpolarized xenon in a lipid emulsion

Duhamel¹,

Choquet

Grillon³

et al. 2001

Magnetic Resonance in Med

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Section: Discussionmentioning

confidence: 99%

“…All operative procedures and animal care strictly conformed to the French Government guidelines (decree no. 87-848 of October 19,1987, licenses 006722 and A38071).…”

Section: Animal Preparation Proceduresmentioning

confidence: 99%

Xenon‐129 MR imaging and spectroscopy of rat brain using arterial delivery of hyperpolarized xenon in a lipid emulsion

Duhamel¹,

Choquet

Grillon³

et al. 2001

Magnetic Resonance in Med

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“…The mean percentage of ischemic damage, calculated in relation to the volume of the ipsilateral hemisphere, was 9.1Ϯ1.7% in the striatum and 25.2Ϯ5.9% in the cortex. When one considers that the striatum volume is approximately one third as large as the cortex volume, 28 the extent of damage in the striatum was similar to that in the cortex. The volume of the ipsilateral hemisphere (meanϮSEM, 218.9Ϯ11.5 mm 3 ) was 11% higher than the volume of the contralateral hemisphere (meanϮSEM, 196.2Ϯ7.8 mm 3 ).…”

Section: Ischemic Brain Damagementioning

confidence: 99%

Striatal Outflow of Adenosine, Excitatory Amino Acids, γ-Aminobutyric Acid, and Taurine in Awake Freely Moving Rats After Middle Cerebral Artery Occlusion

Melani

Pantoni

Corsi

et al. 1999

Stroke

136

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Background and Purpose-While a number of studies have investigated transmitter outflow in anesthetized animals after middle cerebral artery occlusion (MCAO) performed by craniectomy, studies have never been performed after MCAO induced by intraluminal filament. In addition, it has been reported that after MCAO, infarct volume correlates with functional outcome and with transmitter outflow, although there are no studies that demonstrate a direct correlation between transmitter outflow and functional outcome. The purpose of the present study was to assess excitatory amino acids, ␥-aminobutyric acid, taurine, and adenosine outflow in awake rats after intraluminal MCAO and to determine whether, in the same animal, outflow was correlated with neurological outcome and histological damage. Methods-Vertical microdialysis probes were placed in the striatum of male Wistar rats. After 24 hours, permanent MCAO was induced by the intraluminal suture technique. The transmitter concentrations in the dialysate were determined by high-performance liquid chromatography. Twenty-four hours after MCAO, neurological deficit and histological outcome were evaluated. Results-All transmitters significantly increased after MCAO. Twenty-four hours after MCAO, the rats showed a severe sensorimotor deficit and massive ischemic damage in the striatum and in the cortex (9Ϯ2% and 25Ϯ6% of hemispheric volume, respectively). Significant correlations were found between the efflux of all transmitters, neurological score, and striatal infarct volume. Conclusions-In this study, for the first time, amino acid and adenosine extracellular concentrations during MCAO by the intraluminal suture technique were determined in awake and freely moving rats, and a significant correlation was found between transmitter outflow and neurological deficit. The evaluation of neurological deficit, histological damage, and transmitter outflow in the same animal may represent a useful approach for studying neuroprotective properties of new drugs/agents against focal ischemia. (Stroke. 1999;30:2448-2455.)

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“…18,19,37,38 This task can be modified to evaluate various aspects of cognitive functioning to provide information beyond a simple performance score. For example, the MWM has been used in rat MCAO studies to test acquisition, 18,19,38,39 long-term retention, 39 swim patterns and search strategy, 19,38,40 and simple cued versus cognitive learning. 18 Such cognitive tests can supply important information about the functional state of the animal after MCAO in addition to its sensorimotor capacity.…”

mentioning

confidence: 99%

A Comparison of Long-Term Functional Outcome After 2 Middle Cerebral Artery Occlusion Models in Rats

Roof

Schielke²,

Ren³

et al. 2001

Stroke

122

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Background and Purpose-Proven behavioral assessment strategies for testing potential therapeutic agents in rat stroke models are needed. Few studies include tasks that demand higher levels of sensorimotor and cognitive function. Because behavioral outcome and rate of recovery vary among ischemia models, there is a need to characterize and compare performance on specific tasks across models. Methods-To this end, sensorimotor and cognitive deficits were assessed during a 5-week period after either permanent proximal middle cerebral artery occlusion (pMCAO) or permanent distal middle cerebral artery occlusion combined with a 90-minute occlusion of both common carotid arteries (dMCAO/tCCAO) in Sprague-Dawley rats. The EBST, hindlimb and forelimb placing, and cylinder tests were given at regular intervals postinjury to assess sensorimotor function. Cognitive function was assessed with a multitrial water navigation task. Results-pMCAO, which caused both striatal and cortical damage, produced persistent sensorimotor and cognitive deficits. Limb placing responses and postural reflexes were impaired throughout the month of testing. A persistent bias for using the ipsilateral forelimb for wall movements in the cylinder test was observed as well as a bias for landing on the opposite forelimb. pMCAO rats were also impaired in the water navigation task. dMCAO/tCCAO, which caused only cortical damage, produced similar sensorimotor deficits, but these were greatly diminished by 2 weeks after injury.No impairment was found for water tank navigation. Correlations between forelimb placing (both models), water navigation performance (pMCAO model), and sensorimotor asymmetry (dMCAOtCCAO model) and infarct volume were observed. Conclusions-Based on the range of functions affected and stability of observed deficits, the pMCAO model appears to be preferable to the dMCAO/tCCAO model for use in assessing therapeutic agents for stroke.

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Effect of ischemic cerebral volume changes on behavior

Cited by 30 publications

References 27 publications

Xenon‐129 MR imaging and spectroscopy of rat brain using arterial delivery of hyperpolarized xenon in a lipid emulsion

Xenon‐129 MR imaging and spectroscopy of rat brain using arterial delivery of hyperpolarized xenon in a lipid emulsion

Striatal Outflow of Adenosine, Excitatory Amino Acids, γ-Aminobutyric Acid, and Taurine in Awake Freely Moving Rats After Middle Cerebral Artery Occlusion

A Comparison of Long-Term Functional Outcome After 2 Middle Cerebral Artery Occlusion Models in Rats

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