Effect of isoflavone (SOY) on histopathology of reproductive organs of rabbits (Oryctolagus cuniculus)

Abstract

The main source of isoflavones is soy foods. Soy isoflavones have been extensively studied for its antiestrogenic and estrogenic effects. These exogenous chemicals have less potent effect but there mechanism of action is same as endogenous estrogen. They have adverse effects on histology of testis and ovaries. In present study we evaluate the effect of soy isoflavone on histopathological changes in testis and ovaries. Selected 84 adult rabbits were divided into 8 groups. The dose groups were (2.5 mg/kg per body weight= A group), (3.5 mg/kg per body weight= B group), (5 mg/kg per body weight = C group) and control (D) group separately for male and female. The results showed that soy isoflavone have negative effect on reproductive organs and more pronounced effect on male than female. Many histological problems were observed in testis and ovaries. This study shows that soy foods are not good for reproductive health, and use of soy foods in high amount for prolonged time should be prohibited.