Effect of isoflavones on breast cancer cell development and their impact on breast cancer treatments

Hatono, Minami; Ikeda, Hirokuni; Suzuki, Yoko; Kajiwara, Yukiko; Kawada, Kenichi; Tsukioki, Takahiro; Kochi, Mariko; Suzawa, Ken; Inomata, Takayuki; Yamamoto, Hiromasa; Shien, Tadahiko; Yamane, Masaomi; Taira, Naruto; Doihara, Hiroyoshi; Toyooka, Shinichi

doi:10.1007/s10549-020-05957-z

Cited by 13 publications

(9 citation statements)

References 28 publications

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“…Three isoflavone derivatives, 50, 52 and 54, are structurally related to estrogen steroid sex hormones, such as estrone (E1), estradiol (E2), estriol (E3) and estetrol (E4) [25]. Therefore, they can exhibit estrogenic and/or antiestrogenic effects [26].…”

Section: Molecular Docking Using Autodockmentioning

confidence: 99%

Metabolic Profile, Biotransformation, Docking Studies and Molecular Dynamics Simulations of Bioactive Compounds Secreted by CG3 Strain

et al. 2022

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Actinobacteria isolated from untapped environments and exposed to extreme conditions such as saltpans are a promising source of novel bioactive compounds. These microorganisms can provide new molecules through either the biosynthetic pathway or the biotransformation of organic molecules. In the present study, we performed a chemical metabolic screening of secondary metabolites secreted by the new strain CG3, which was isolated from a saltpan located in the Sahara of Algeria, via high-performance liquid chromatography coupled with high-resolution mass spectrometry (HPLC-ESI-HRMS). The results indicated that this strain produced five new polyene macrolactams, kenalactams A–E, along with two known compounds, mitomycin C and 6″-hydroxy-4,2′,3′,4″ tetramethoxy-p-terphenyl. Furthermore, the CG3 isolate could have excellent properties for converting the aglycone isoflavone glycitein to the compounds 6,7-dimethoxy-3-(4-methoxyphenyl)chromen-4-one (50) and 6,7-dimethoxy-3-phenylchromen-4-one (54), and the isoflavone genistein can be converted to 5,7-dimethoxy-3-(4-methoxyphenyl)chromen-4-one (52). Docking studies and molecular dynamics simulations indicated that these three isoflavones, generated via biotransformation, are potent inhibitors of the target protein aromatase (CYP19A1); consequently, they can be used to prevent breast cancer risk in postmenopausal women.

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Section: Molecular Docking Using Autodockmentioning

confidence: 99%

Metabolic Profile, Biotransformation, Docking Studies and Molecular Dynamics Simulations of Bioactive Compounds Secreted by CG3 Strain

et al. 2022

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“…Fernández et al studied the beneficial effects of five flavonoids, together with conventional chemotherapy, on three colorectal cancer cell lines (HCT116, HT-29, and T84) [23]. Hatono's group demonstrated the effect of isoflavones on breast cancer cell development and their impact on breast cancer treatments [24]. Goh and collaborators demonstrated the chemopreventive role of nobiletin, extracted from citrus fruit, in colon cancer cells [25].…”

Section: Flavonoids and Cancer: Role Of Nf-κb Signaling Pathwaymentioning

confidence: 99%

Effects of Flavonoids on Cancer, Cardiovascular and Neurodegenerative Diseases: Role of NF-κB Signaling Pathway

Barreca

Alessandro

Corrado

2023

IJMS

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Flavonoids are polyphenolic phytochemical compounds found in many plants, fruits, vegetables, and leaves. They have a multitude of medicinal applications due to their anti-inflammatory, antioxidative, antiviral, and anticarcinogenic properties. Furthermore, they also have neuroprotective and cardioprotective effects. Their biological properties depend on the chemical structure of flavonoids, their mechanism of action, and their bioavailability. The beneficial effects of flavonoids have been proven for a variety of diseases. In the last few years, it is demonstrated that the effects of flavonoids are mediated by inhibiting the NF-κB (Nuclear Factor-κB) pathway. In this review, we have summarized the effects of some flavonoids on the most common diseases, such as cancer, cardiovascular, and human neurodegenerative diseases. Here, we collected all recent studies describing the protective and prevention role of flavonoids derived from plants by specifically focusing their action on the NF-κB signaling pathway.

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“…For this reason, ISFs are called “phytoestrogens”. Due to the physiological effects of ISFs, scientific research has increased in recent decades on the effects of soy ISFs on human health, , including antioxidant activity, obesity prevention, diabetes prevention, cancer risk reduction, blood pressure reduction, and bone loss inhibition . ISFs also have preventive effects against menopausal symptoms .…”

Section: Introductionmentioning

confidence: 99%

Alkaline–Enzymatic Hydrolysis for Improved Quantitation of Total Isoflavones in Soy Protein-Based Infant Food by UPLC–MS/MS

Gu,

Pang,

et al. 2023

ACS Food Sci. Technol.

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Early life exposure to isoflavones may have detrimental effects on the reproductive system. However, determining the total 12 isoflavones found in soybeans is challenging due to the unavailability of reference standards for all isoflavones. In this study, a method was developed using only three aglycone isoflavones to quantitate all isoflavones. Three different β-glucosidases were evaluated to hydrolyze all glucoside isoflavones, but resistance was observed for malonyl and acetyl glucosides. To address this issue, 80% methanol containing 0.3% NaOH was used as the extraction solution and to facilitate the hydrolysis, allowing 0.5 U of βglucosidase from Thermotoga maritima to efficiently hydrolyze all glucoside isoflavones with the corresponding aglycones obtained within 10 min. Combined with ultraperformance liquid chromatography with tandem mass spectrometry (UPLC-MS/MS), efficient quantitation of all isoflavones was achieved with low limits of quantitation (0.010−0.23 μg/g) and good recoveries (97.0−98.6%) for soy protein-based infant food. This developed method is expected to normalize total isoflavones to aglycone equivalents to avoid overestimating isoflavone contents caused by the presence of glucoside forms.

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Effect of isoflavones on breast cancer cell development and their impact on breast cancer treatments

Cited by 13 publications

References 28 publications

Metabolic Profile, Biotransformation, Docking Studies and Molecular Dynamics Simulations of Bioactive Compounds Secreted by CG3 Strain

Metabolic Profile, Biotransformation, Docking Studies and Molecular Dynamics Simulations of Bioactive Compounds Secreted by CG3 Strain

Effects of Flavonoids on Cancer, Cardiovascular and Neurodegenerative Diseases: Role of NF-κB Signaling Pathway

Alkaline–Enzymatic Hydrolysis for Improved Quantitation of Total Isoflavones in Soy Protein-Based Infant Food by UPLC–MS/MS

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