Effect of isolated vitamin D supplementation on the rate of falls and postural balance in postmenopausal women fallers

Cangussu, Luciana Mendes; Nahás-Neto, Jorge; Orsatti, Cláudio Lera; Poloni, Priscila Ferreira; Schmitt, Eneida Boteon; Almeida-Filho, Benedito; Nahás, Eliana Aguiar Petri

doi:10.1097/gme.0000000000000525

Cited by 55 publications

(49 citation statements)

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“…2019;11(1):3-5 EDITORIAL Muscle strength (especially proximal) can be modestly improved with vitamin D supplementation in the elderly with serum levels of 25OHD <12 ng/mL 16 . According to this concept, supplementation for 9 months with 1,000 IU of vitamin D 3 daily significantly decreased the first falls and the total of them in more than 50% of patients 13 .…”

Section: Quesada Gómez Jm Sosa Henríquez Mmentioning

confidence: 98%

“…nuclear magnetic 11 . Some intervention studies show that administration of 800-1,000 IU of vitamin D 3 per day, or slightly more than its weekly equivalent, improves strength and balance in the elderly with vitamin D deficiency [12][13][14] .In addition to function, we have multiple observational studies that relate vitamin D deficiency with frailty and the incidence of falls. Thus, an analysis of 18 studies revealed an odds ratio (OR) of falls significantly greater than 1.23-1.44 for subjects with 25OHD concentrations below 10-20 ng/mL 15 .…”

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Vitamina D y función muscular

Gómez

Henríquez

2019

Rev Osteoporos Metab Miner

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In 1922, at Johns Hopkins University in Baltimore, Professor McCollum discovered a factor, which has since been referred to as vitamin D, following the alphabetical order of the other vitamins identified up to that time. It is capable of curing rickets in children and osteomalacia in adults. Diseases in which, as we know from the first scientific descriptions published in London in the midseventeenth century, muscle involvement consisting of weakness and generalized hypotonia is associated with bone involvement, its main characteristic. Therefore, since the discovery of vitamin D, it has been associated not only with bone health but also with muscle health 1 . Paradoxically, at present, there is no consensus on the potential beneficial effects of vitamin D supplementation on muscle function, balance and risk of falls, a situation highlighted in the last meta-analysis published by Bolland et al. 2 , who review in 81 randomized clinical trials (RCTs) that include 53,537 participants the effect of vitamin D on fractures and falls as a primary outcome. The pooled analyses showed that vitamin D supplementation had no effect on falls (37 RCTs, n=34,144, RR=0.97, 95% confidence interval -0.93 to 1.02), what the authors concluded that "vitamin D supplementation does not exert significant effects in falls", affirming that "potential future trials will probably not alter those conclusions, and that, therefore, there is little justification for the use of vitamin D supplements. to maintain or improve musculoskeletal health, indicating that clinical guidelines should reflect these findings" 2 . From this publication, many physicians and patients could mistakenly conclude that they can stop prescribing or taking vitamin D supplements, which is a potentially dangerous message, given the high prevalence of vitamin D deficiency in Spain 3 .Loss of muscle strength and/or function, severe invalidating myopathy predominantly proximal with diffuse muscular or skeletal pain in adults, generalized muscle atrophy and electromyographic abnormalities, such as polyphasic motor unit, potentials with shortened duration and decreased range, involvement of Type II muscle fiber atrophy (of rapid contraction) and marked fatty infiltration are findings in severe and sustained vitamin D deficiency, in severe renal insufficiency, or in the congenital absence of the CYP27B1 gene due to inability to adequately synthesize 1,25 dihydroxyvitamin D (1,25 DHCC), hormonally active metabolite of the endocrine system of vitamin D, with rapid improvement of muscle function after vitamin D or 1,25 DHC supplementation in these patients. More subtle changes in muscle function can be observed in subjects with less severe and perhaps less chronic vitamin D deficiency 4 .In our current issue, Gómez Alonso et al. 5 , present an article in which they observe that in patients of both sexes of the cohort EVOS (European Study of Vertebral Osteoporosis) that maintain serum levels of calcidiol higher than 20 ng/mL present greater grip strength in the hands, maintenance o...

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Section: Quesada Gómez Jm Sosa Henríquez Mmentioning

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Vitamina D y función muscular

Gómez

Henríquez

2019

Rev Osteoporos Metab Miner

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“…Older adults supplemented with vitamin D demonstrate reduced risk of falls compared with non-vitamin D supplemented controls [2][3][4][5], though not all studies found a beneficial effect of supplementation on postural stability [6,7]. Muscle strength [5]; muscle function, including timed up-and-go [5,8] and chair stands [9]; balance [3][4][5]8]; reaction time [4] and gait [8] improved following vitamin D supplementation. However, positive studies often targeted vitamin D-deficient individuals [8] with a history of falls [3,4,9] and examined doses <4000 IU daily for <three years.…”

Section: Introductionmentioning

confidence: 99%

“…Muscle strength [5]; muscle function, including timed up-and-go [5,8] and chair stands [9]; balance [3][4][5]8]; reaction time [4] and gait [8] improved following vitamin D supplementation. However, positive studies often targeted vitamin D-deficient individuals [8] with a history of falls [3,4,9] and examined doses <4000 IU daily for <three years. Conversely, randomized clinical vitamin D supplementation trials demonstrated no effect of 800 IU supplementation in older women with a history of falls [9] and a detrimental effect of 2800 IU supplementation in older vitamin D-insufficient women on muscle function and postural stability [6,7].…”

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confidence: 99%

Postural Balance Effects Associated with 400, 4000 or 10,000 IU Vitamin D3 Daily for Three Years: A Secondary Analysis of a Randomized Clinical Trial

et al. 2020

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Vitamin D supplementation is proposed as a fall prevention strategy, as it may improve neuromuscular function. We examined whether three years of vitamin D supplementation (400, 4000 or 10,000 IU daily) affects postural sway in older adults. Three hundred and seventy-three non-osteoporotic, vitamin D-sufficient, community-dwelling healthy adults, aged 55–70 years, were randomized to 400 (n = 124), 4000 (n = 125) or 10,000 (n = 124) IU daily vitamin D3 for three years. Sway index was assessed at baseline, 12-, 24- and 36-months using the Biosway machine. We tested participants under four conditions: eyes open or eyes closed with firm (EOFI, ECFI) or foam (EOFO, ECFO) surfaces. Secondary assessments examined sway in the anterior-posterior (AP) and medio-lateral (ML) directions. Linear mixed effects models compared sway between supplementation groups across time. Postural sway under EOFO and ECFO conditions significantly improved in all supplementation groups over time. Postural sway did not differ between supplementation groups at any time under any testing conditions in normal, AP or ML directions (p > 0.05 for all). Our findings suggest that high dose (4000 or 10,000 IU) vitamin D supplementation neither benefit nor impair balance compared with 400 IU daily in non-osteoporotic, vitamin D-sufficient, healthy older adults.

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Prevention of Falls

Bischoff‐Ferrari

2018

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism

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Effect of isolated vitamin D supplementation on the rate of falls and postural balance in postmenopausal women fallers

Abstract: In Brazilian postmenopausal women fallers, isolated vitamin D supplementation for 9 months resulted in a lower incidence of falls and improvement in postural balance.

Cited by 55 publications

References 30 publications

Vitamina D y función muscular

Vitamina D y función muscular

Postural Balance Effects Associated with 400, 4000 or 10,000 IU Vitamin D3 Daily for Three Years: A Secondary Analysis of a Randomized Clinical Trial

Prevention of Falls

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