Effect of isolation on behavioural models involving serotonergic 5-HT2 and 5-HT1a receptors

Coudereau, Jean-Pierre; Monier, Claire; Frances, Henriette

doi:10.1016/0278-5846(95)00121-b

Cited by 6 publications

(3 citation statements)

References 34 publications

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“…Thus, social isolation could have altered the rewarding properties of morphine through an action on dopaminergic systems. An effect of neurotransmitters other than dopamine cannot be excluded, since behavioral results (Wright et al 1991;Coudereau 1995) have shown that isolation may alter serotonergic function ; neurochemical studies show that after isolation the 5-HIAA concentration and the 5-HIAA/5-HT ratio are decreased in the nucleus accumbens . A second hypothesis could be an isolation-induced alteration of the sensitivity or of the number of opiate receptors.…”

Section: Discussionmentioning

confidence: 96%

Isolation impairs place preference conditioning to morphine but not aversive learning in mice

Coudereau

Debray²,

Monier

et al. 1997

Psychopharmacology

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Morphine (8-100 mg/kg IP) induces place preference conditioning in mice. The effect of two different periods of isolation (15 and 30 days) was examined. Mice isolated for 15 days but not 30 days exhibited place preference conditioning to morphine (8 mg/kg). After 30 days of isolation morphine could not induce place preference conditioning with the following doses (8, 16, 64, 100 mg/kg). Social regrouping of male mice previously isolated for 30 days with naive female mice for 15 or 30 days resulted in a reappearance of the conditioned place preference to morphine (16 mg/kg). The specificity of this associative deficit was examined by testing learning in isolated compared to non-isolated mice in two distinct settings: escape learning in the Morris water maze and passive avoidance acquisition and retention. On the Morris water maze isolated mice did not differ from non-isolated mice regarding place learning, the probe trial or extinction. Isolated mice were unimpaired in passive avoidance acquisition and retention. It was concluded that the deficits in place preference conditioning were not the result of a global learning impairment in isolated mice.

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Section: Discussionmentioning

confidence: 96%

Isolation impairs place preference conditioning to morphine but not aversive learning in mice

Coudereau

Debray²,

Monier

et al. 1997

Psychopharmacology

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“…Several studies have shown that 5-HT1 A receptors are involved in response to acute or chronic stress (Mendelson and McEwen, 1991;Flugge et al, 1998), social isolation (Coudereau et al, 1995), and environmental enrichment (Rasmuson et al, 1998). Serotonin itself appears to be downregulated in the dorsal hippocampus and in the mPFC of rat pups after repeated maternal separation (Matthews et al, 2001), which may indicate counterbalanced regulation between the transmitter and this receptor subtype.…”

Section: Serotonin: 5-ht1 a Receptorsmentioning

confidence: 99%

Separation-Induced Receptor Changes in the Hippocampus and Amygdala ofOctodon degus: Influence of Maternal Vocalizations

et al. 2003

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Relatively little is known about the basic mechanisms that play a role in the vulnerability of the developing brain toward adverse environmental influences. Our study in the South American rodent Octodon degus revealed that repeated brief separation from the parents and exposure to an unfamiliar environment induces in the hippocampal formation of male and female pups an upregulation of D1 and 5-HT1A receptor density in the stratum radiatum and stratum lacunosum moleculare of the CA1 region. In the CA3 region, only the 5-HT1A receptors were upregulated; no changes were observed for D1 receptors in this region. GABA(A) receptor density in the hippocampus and amygdala was downregulated (nonsignificant trend) after parental separation. The acoustic presence of the mother during parental separation suppressed the D1 and 5-HT1A receptor upregulation in some regions of the hippocampus; no such suppressing influence was observed for the GABA(A) receptors. In the basomedial amygdala, the maternal calls enhanced the separation-induced 5-HT1A receptor upregulation in the male pups, whereas in the female pups the separation-induced receptor densities were not only suppressed by the maternal call but further downregulated, compared with the control group. These results demonstrate that early adverse emotional experience alters aminergic function within the hippocampus and amygdala and that the mother's voice, a powerful emotional signal, can modulate these effects in the developing limbic system.

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“…In the latter, 8-OH-DPAT was not only ineffective but even decreased food intake, , possibly by a modified sensitivity of 5-HT 1A autoreceptors or brain 5-HT metabolism as a consequence of food deprivation (refs − , but see ref ). In free-feeding mice, systemic injection of 8-OH-DPAT enhanced the basal feeding duration and the total amount of consumed food, , which was antagonized by pretreatment with the selective 5-HT 1A receptor antagonist WAY100635 . Interestingly, Blanchard and colleagues demonstrated that a hyperphagic effect in mice was obtained only after the administration of a high dose of 8-OH-DPAT (10 mg/kg) in association with symptoms of the 5-HT-syndrome, suggesting an involvement of postsynaptic 5-HT 1A receptors.…”

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confidence: 99%

Modulatory Role of Postsynaptic 5-Hydroxytryptamine Type 1A Receptors in (±)-8-Hydroxy-N,N-dipropyl-2-aminotetralin-Induced Hyperphagia in Mice

Brosda

Müller

Bert

et al. 2015

ACS Chem. Neurosci.

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Brain serotonin (5-HT) is involved in the control of food intake. The ingestive effects of 5-HT are mediated by various receptor subtypes, among others the 5-HT1A receptor. While the involvement of presynaptic 5-HT1A receptors is regarded as certain, the role of postsynaptic 5-HT1A receptors is rather vague. Here, we studied the role of the 5-HT1A receptor on feeding in non-food-deprived and food-deprived (young adult and adult, both sexes) wild-type NMRI mice as well as transgenic NMRI mice, which are characterized by a distinct overexpression of postsynaptic 5-HT1A receptors. The known hyperphagic effect of the 5-HT1A receptor full agonist 8-OH-DPAT ((±)-8-hydroxy-N,N-dipropyl-2-aminotetralin) in non-food-deprived animals was demonstrated in male NMRI wild-type mice and could be antagonized by the selective 5-HT1A receptor antagonist WAY100635. In transgenic mice, this hyperphagic response was induced at lower doses, with an earlier onset and even in females. However, in adult male transgenic mice, the hyperphagic effect did not occur. In food-deprived NMRI wild-type as well as transgenic mice, 8-OH-DPAT first induced a hypophagic and subsequently a hyperphagic effect. Again, in transgenic animals most responses occurred at lower doses and with an earlier onset. The results indicate that postsynaptic 5-HT1A receptors exert a modulatory function in food intake in free-feeding and fasted mice, which for the first time shows an involvement of postsynaptic 5-HT1A receptors in feeding behavior. Understanding the function of pre- and postsynaptic 5-HT1A receptors may help to achieve new insights into the regulation of food intake and foster prospective treatment strategies for eating disorders.

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Effect of isolation on behavioural models involving serotonergic 5-HT2 and 5-HT1a receptors

Cited by 6 publications

References 34 publications

Isolation impairs place preference conditioning to morphine but not aversive learning in mice

Isolation impairs place preference conditioning to morphine but not aversive learning in mice

Separation-Induced Receptor Changes in the Hippocampus and Amygdala ofOctodon degus: Influence of Maternal Vocalizations

Modulatory Role of Postsynaptic 5-Hydroxytryptamine Type 1A Receptors in (±)-8-Hydroxy-N,N-dipropyl-2-aminotetralin-Induced Hyperphagia in Mice

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