Effect of isolation on pain threshold and on different effects of morphine

Coudereau, Jean-Pierre; Monier, Claire; Bourre, Jean‐Marie; Frances, Henriette

doi:10.1016/s0278-5846(97)00094-8

Cited by 30 publications

(22 citation statements)

References 49 publications

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“…Therefore, the effect of isolation might instead depend on the subjects' age while they were isolated: If isolation during the postweaning stage increases rats' reactivity while that during the postmaturity stage decreases it, these two effects should offset each other in subjects isolated for 12 weeks. This same question can be found in other studies (Archer, 1969;Coudereau et al, 1997;Korn & Moyer, 1968;Paulus et al, 1998).…”

supporting

confidence: 82%

“…Several studies, for example, have shown that the reactivity of isolated rats to electric shock increases (Sahakian & Robbins, 1977;Viken, Moore, Knutson, & Fordyce, 1982) while others have found it to decrease (Coudereau, Monier, Bourre, & Frances, 1997;Gentsch et al, 1988;Schwandt, 1993;Viveros et al, 1988). As for the reactivity to restraint, some studies have reported an increases in rats reared in isolation (Gamallo, Villanua, Trancho, & Fraile, 1986;Płaźnik, Pałejko, Stefański, & Kostowski, 1993) whereas others have shown a decrease in reactivity (Giralt & Armario, 1989).…”

mentioning

confidence: 99%

“…It has been suggested in many studies that the duration of the isolated period or the age of the subjects might affect the results (e.g., Archer, 1969;Coudereau et al, 1997;Einon & Morgan, 1977;Gentsch, Lichsteiner, & Feer, 1981;Paulus, Bakshi, & Geyer, 1998). Rearing in isolation can be considered as the deprivation of social contacts that include social play and aggressive behavior (Einon, Morgan, & Kibbler, 1978;Hall, 1998;Ikemoto & Panksepp, 1992;van den Berg, Van Ree, & Spruijt, 1999).…”

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confidence: 99%

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The effects of age and isolation period on two phases of behavioral response to foot shock in isolation‐reared rats

Arakawa

2002

Developmental Psychobiology

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Using rats as subjects, the effects of a period of isolation and the subjects' age during isolation on the response to foot shock were systematically examined in three experiments. Both the thresholds of shock that evoked a jumping response and that evoked a thrashing response were measured. The results suggest that the threshold for jumping response decreased when rats were isolated during the postweaning stage of development. On the other hand, the threshold for thrashing response decreased when the subjects were isolated for more than 39 days, independently of their age during isolation. Possible causes of the differential effects of these two factors are discussed in relation to the developmental process of these two behavioral indices.

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confidence: 82%

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confidence: 99%

mentioning

confidence: 99%

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The effects of age and isolation period on two phases of behavioral response to foot shock in isolation‐reared rats

Arakawa

2002

Developmental Psychobiology

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“…For example, housing isolation and crowding can both affect animal welfare (e.g., ref. 37), and directly affect pain sensitivity [38][39][40][41][42][43] , and the effects of cage density might be sex-specific 44 . Housing enrichment using physical objects has been shown to ameliorate pain [45][46][47] .…”

Section: Jeffrey S Mogilmentioning

confidence: 99%

Laboratory environmental factors and pain behavior: the relevance of unknown unknowns to reproducibility and translation

Mogil

2017

Lab Anim

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“…Along this line, isolation rearing from postweaning reduces pain sensitivity to noxious thermal stimuli in rodents. [26][27][28]107) We have recently demonstrated that isolation rearing causes activation of the anterior cingulate cortex, periaqueductal gray matter, and rostral ventromedial medulla in mice, and that spinal 5-HT 1A receptors are involved in isolation rearing-induced hypoalgesia in capsaicin-induced nociception.…”

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confidence: 99%

Neuropharmacologic Studies on the Brain Serotonin<sub>1A</sub> Receptor Using the Selective Agonist Osemozotan

Matsuda

2013

Biological & Pharmaceutical Bulletin

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Alterations in serotonin (5-HT) neurochemistry have been implicated in the etiology of major neuropsychiatric disorders such as anxiety-spectrum disorders, depression, and schizophrenia. The neuromodulatory effects of 5-HT are mediated through 14 receptor subtypes, and those receptors, including the 5-HT 1A receptor, are considered to be potential targets for the treatment of psychiatric disorders. We developed the novel 5-HT 1A receptor agonist MKC-242 (called osemozotan) and characterized its neurochemical and pharmacological profiles. 5-HT 1A receptor agonists modulate the release of amine neurotransmitters through the activation of presynaptic or postsynaptic 5-HT 1A receptors in the brain. The agonist has antianxiety and antidepressant effects and improves abnormal behaviors such as aggressive behavior and deficits of prepulse inhibition in isolation-reared mice. We also demonstrated that spinal 5-HT 1A receptor activation is involved in isolation rearing-induced hypoalgesia. Concerning the mechanism for induction of isolation-induced abnormal behaviors, we have recently found that the raphe-prefrontal 5-HT system plays a key role in encounter stimulation-induced hyperactivity in isolation-reared mice. Furthermore, we showed that osemozotan attenuates psychostimulant-induced behavioral sensitization and that prefrontal dopamine release is enhanced by functional interaction between the 5-HT 1A receptor and other receptors. This review summarizes the neuropharmacology of the 5-HT 1A receptor, focusing on our studies using osemozotan, and suggests that the 5-HT 1A receptor may be a target molecule for the treatment of psychiatric disorders, pain, and drug dependence.

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Effect of isolation on pain threshold and on different effects of morphine

Cited by 30 publications

References 49 publications

The effects of age and isolation period on two phases of behavioral response to foot shock in isolation‐reared rats

The effects of age and isolation period on two phases of behavioral response to foot shock in isolation‐reared rats

Laboratory environmental factors and pain behavior: the relevance of unknown unknowns to reproducibility and translation

Neuropharmacologic Studies on the Brain Serotonin<sub>1A</sub> Receptor Using the Selective Agonist Osemozotan

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