Effect of isotretinoin on induced tooth movement in rats

Parra, Ariane Ximenes Graciano; Johann, Aline Cristina Batista Rodrigues; Hardy, Ana Maria Trindade Grégio; Oppitz, Layza Rossatto; Araújo, Cristiano Miranda de; Tanaka, Orlando Motohiro; Filho, Odilon Guariza; Camargo, Elisa Souza

doi:10.1016/j.ajodo.2019.12.022

Cited by 4 publications

(4 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results of the study indicated that low-moderate doses of isotretinoin, did not significantly alter bone morphology in the treated animals. This finding is consistent with the findings of Graciano Parra et al, who evaluated the systemic effects of isotretinoin on the femurs of animals and found no relevant effects on bone morphology compared to animals treated only with soy oil ( Graciano Parra et al, 2021 ). Similarly, Nishio et al did not observe significant changes in bone morphology in the tibia of their animal model with isotretinoin treatment ( Nishio et al, 2017 ).…”

Section: Discussionsupporting

confidence: 92%

“…In our study, we found that isotretinoin at a dosage of 7.5 mg/kg/day; for 21 days and 14 days of administration and 14 days and 7 days of OTM did have a significant influence on tooth displacement when compared to animals that underwent tooth movement alone for 14 days. Unlike Graciano Parra et al, being the only study that performed OTM with a force of 30cN in conjunction with treatment with isotretinoin at the same dosage also analyzed in our study – found no significant differences in tooth displacement between animals treated with isotretinoin and undergoing OTM alone ( Graciano Parra et al, 2021 ). These discrepancies findings could be attributed to the difference between forces used at OTM and even the age or weight of the animals during the experimentation.…”

Section: Discussioncontrasting

confidence: 64%

“…The investigation of the effects of both OTM and isotretinoin on bone morphology showed no significant impact on the microtomographic parameters in groups ISO14a-OTM7, ISO14b-OTM7, ISO21a-OTM14 and ISO21b-OTM14 groups. The only existing study found in the literature that examined OTM with isotretinoin and analyzed the same microtomographic parameters (BV/TV, Tb.Th, Tb.N, and Tb.Sp) also reported no significant difference in bone morphology ( Graciano Parra et al, 2021 ). However, it is important to note that this particular study analyzed the parameters in the distal epiphysis of the femur, rather than between the roots of the maxillary first molar, which was the focus of our study.…”

Section: Discussionmentioning

confidence: 91%

“…The interrelation between isotretinoin and tooth movement has been the subject of previous studies, but the results remain inconclusive, and there are still unresolved issues ( Nishio et al, 2017 ; Graciano Parra et al, 2021 ).Isotretinoin is primarily used among teenagers and young adults, coincidentally the age group that also often undergoes orthodontic treatment ( Bergoli et al, 2011 ; Leachman et al, 1999 ; Downs, 2003 ; Erdogan et al, 2006 ). Considering that there are individuals undergoing orthodontic treatment while also using isotretinoin, and that there is limited information on the effects of this combination in the literature, we are proposing this study to evaluate the influence of isotretinoin on OTM.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Therapeutic dosage of isotretinoin in rats may influence orthodontic tooth movement

Ferreira,

Botazzo Delbem,

Ervolino

et al. 2024

Bone Reports

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 92%

Section: Discussioncontrasting

confidence: 64%

Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Therapeutic dosage of isotretinoin in rats may influence orthodontic tooth movement

Ferreira,

Botazzo Delbem,

Ervolino

et al. 2024

Bone Reports

View full text Add to dashboard Cite

Effects of isotretinoin on tooth movement, orthodontically induced and non‐orthodontic root resorption: A micro‐CT study

Gok,

Halicioglu,

Keles

et al. 2024

Orthod Craniofacial Res

View full text Add to dashboard Cite

ObjectivesThis study aims to investigate whether cumulative dose‐dependent isotretinoin (Roaccutane®) could affect orthodontic tooth movement (OTM) and root resorption.Materials and MethodsNinety male Wistar Albino rats were divided into 4 groups. While, the control (SALINE), solvent (SOYBEAN) and orthodontic drug (ISOTM) groups underwent orthodontic force, the non‐orthodontic drug group (ISO) did not. The rats were administrated saline, soybean oil (SBO) and isotretinoin diluted in SBO (ISOTM, ISO) for 30 days, respectively. Six rats were euthanized in each orthodontic group. Fifty grams of orthodontic force was applied to the remaining rats' first molars using the incisors as anchorage. Six more rats in each group were euthanized on the 7th, 14th and 21st days of the force application. In the ISO group, six rats were euthanized on the 37th, 44th and 51st days of administration. Six rats that were euthanized for ISOTM on the 30th day were also used for ISO to reduce the number of rats used. Micro‐computed tomography (micro‐CT) and histological analysis were performed.ResultsIndependent of orthodontic force, isotretinoin caused root resorption in the apical region. However, there was no statistically significant influence of isotretinoin on OTM and orthodontically induced root resorption (OIRR).ConclusionsDespite the lack of strong evidence supporting the orthodontically induced resorptive effect of isotretinoin, this study provided findings regarding the resorptive effects of isotretinoin on non‐orthodontic root resorption. Therefore, the present results underscore the importance of close monitoring during orthodontic treatment to mitigate potential root resorption in patients who use isotretinoin because of acne complaints.

show abstract

Influence of isotretinoin on orthodontic tooth movement in rats: microtomographic and histomorphometric analysis

Ferreira

Antoniali

Ervolino

et al. 2023

Preprint

View full text Add to dashboard Cite

Objective Isotretinoin, also known as 13-cis-retinoic acid, is an isomer of tretinoin, the oxidized form of Vitamin A. Orthodontic tooth movement (OTM) is the result of a cascade of inflammatory responses stimulated by a physical element that is the force generated by orthodontic appliances. Isotretinoin is mainly used among adolescents and young adults, and coincidentally it is this age group that also undergoes orthodontic treatment. Materials and Methods Thirty-five animals were used, and they were randomly divided into 7 groups, containing 5 animals in each group. Group 1: Control; Group 2: OTM for 7 days; Group 3: OTM for 14 days; Group 4: Treated with isotretinoin for 14 days; Group 5: Treated with isotretinoin for 21 days; Group 6: Treated with isotretinoin for 14 days and undergoing OTM for 7 days; Group 7: Treated with isotretinoin for 21 days and undergoing OTM for 14 days. In Groups 6 and 7, the animals were treated with isotretinoin at a dosage of 1.0mg/kg/day for 7 days before OTM and maintained during the movement period in the respective groups. Results There was no significant difference on microtomographic parameters [Trabecular Volume (BV/TV), Trabecular Thickness (Tb.Th), Number of Trabeculae (Tb.N) and Trabecular Separation (Tb.Sp)] and tooth displacement between groups. Conclusion Isotretinoin did not cause a reduction in tooth displacement during OTM when administered at a dose of 1.0mg/kg/day and isotretinoin did not change the microtomographic parameters of animals treated with isotretinoin + OTM.

show abstract

Effect of isotretinoin on induced tooth movement in rats

Cited by 4 publications

References 32 publications

Therapeutic dosage of isotretinoin in rats may influence orthodontic tooth movement

Therapeutic dosage of isotretinoin in rats may influence orthodontic tooth movement

Effects of isotretinoin on tooth movement, orthodontically induced and non‐orthodontic root resorption: A micro‐CT study

Influence of isotretinoin on orthodontic tooth movement in rats: microtomographic and histomorphometric analysis

Contact Info

Product

Resources

About