Effect of Joule heating on electrokinetic transport

Çetin, Barbaros; Li, Dongqing

doi:10.1002/elps.200700601

Cited by 100 publications

(79 citation statements)

References 63 publications

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“…It has been long known in capillary electrophoresis that Joule heating can elevate the buffer temperature and disturb the electroosmotic flow causing significant sample dispersion [30][31][32][33]. The effects of Joule heating on fluid temperature and motion in eDEP have been investigated previously [34][35][36][37][38].…”

Section: Introductionmentioning

confidence: 99%

Joule heating effects on electroosmotic flow in insulator‐based dielectrophoresis

et al. 2011

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Joule heating effects on electroosmotic flow in insulator-based dielectrophoresisInsulator-based dielectrophoresis (iDEP) is an emerging technology that has been successfully used to manipulate a variety of particles in microfluidic devices. However, due to the locally amplified electric field around the in-channel insulator, Joule heating often becomes an unavoidable issue that may disturb the electroosmotic flow and affect the particle motion. This work presents the first experimental study of Joule heating effects on electroosmotic flow in a typical iDEP device, e.g. a constriction microchannel, under DC-biased AC voltages. A numerical model is also developed to simulate the observed flow pattern by solving the coupled electric, energy, and fluid equations in a simplified two-dimensional geometry. It is observed that depending on the magnitude of the DC voltage, a pair of counter-rotating fluid circulations can occur at either the downstream end alone or each end of the channel constriction. Moreover, the pair at the downstream end appears larger in size than that at the upstream end due to DC electroosmotic flow. These fluid circulations, which are reasonably simulated by the numerical model, form as a result of the action of the electric field on Joule heatinginduced fluid inhomogeneities in the constriction region.

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Section: Introductionmentioning

confidence: 99%

Joule heating effects on electroosmotic flow in insulator‐based dielectrophoresis

et al. 2011

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“…High-conductivity buffer has adverse effect on DEP manipulation. 12,13 Therefore, the bio-particles need to be placed into a low-conductivity buffer (i.e., dilute solution). In our design, this step is achieved by the wash unit.…”

Section: Experimentation and Resultsmentioning

confidence: 99%

“…1 Moreover, the electrical conductivity of the buffer solution needs to be low to avoid adverse effects of Joule heating under an applied electric field. 13 On the other hand, ACP offers an ability to create forces in a wider portion of the micro-channel with a lower selectivity, which makes ACP a good candidate for cell manipulation applications such as cell washing. 10,[14][15][16][17] Therefore, for the application of automated cell separation systems where cell washing and cell separation is performed on a single device, the use of ACP (in cell washing) with DEP (in cell separation) may be a subtle and promising solution with superior results compared to single mode of separation devices.…”

Section: Introductionmentioning

confidence: 99%

An integrated acoustic and dielectrophoretic particle manipulation in a microfluidic device for particle wash and separation fabricated by mechanical machining

et al. 2016

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In this study, acoustophoresis and dielectrophoresis are utilized in an integrated manner to combine the two different operations on a single polydimethylsiloxane (PDMS) chip in sequential manner, namely, particle wash (buffer exchange) and particle separation. In the washing step, particles are washed with buffer solution with low conductivity for dielectrophoretic based separation to avoid the adverse effects of Joule heating. Acoustic waves generated by piezoelectric material are utilized for washing, which creates standing waves along the whole width of the channel. Coupled electro-mechanical acoustic 3D multi-physics analysis showed that the position and orientation of the piezoelectric actuators are critical for successful operation. A unique mold is designed for the precise alignment of the piezoelectric materials and 3D side-wall electrodes for a highly reproducible fabrication. To achieve the throughput matching of acoustophoresis and dielectrophoresis in the integration, 3D side-wall electrodes are used. The integrated device is fabricated by PDMS molding. The mold of the integrated device is fabricated using high-precision mechanical machining. With a unique mold design, the placements of the two piezoelectric materials and the 3D sidewall electrodes are accomplished during the molding process. It is shown that the proposed device can handle the wash and dielectrophoretic separation successfully. V C 2016 AIP Publishing LLC.

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“…However, special care is needed since the high electrical voltage may lead to a serious Joule heating effect inside the channel. This severe temperature increase inside the channel due to Joule heating may lead to a bubble formation which can severely interfere with the operation of the device [42]. On the other hand, due to the absence of the electrodes inside the device, iDEP devices are robust, chemically inert and do not require any photolithography, thin-film deposition and lift-off and/or etching for electrode fabrication.…”

Section: Insulator-based Dep (Idep)mentioning

confidence: 99%

“…Depending on the conductivity of the buffer solution and the strength of the electric field, the Joule heating effect can be severe, and cause deterioration of the system performance [8,42]. Moreover, Joule heating may also cause undesired electrothermal effects which may affect the flow field within the micro channel [8].…”

Section: Sample Preparation and Selectivitymentioning

confidence: 99%

Microfluidic bio-particle manipulation for biotechnology

Çetin

Özer

Solmaz

2014

Biochemical Engineering Journal

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a b s t r a c tMicrofluidics and lab-on-a-chip technology offers unique advantages for the next generation devices for diagnostic therapeutic applications. For chemical, biological and biomedical analysis in microfluidic systems, there are some fundamental operations such as separation, focusing, filtering, concentration, trapping, detection, sorting, counting, washing, lysis of bio-particles, and PCR-like reactions. The combination of these operations led to the complete analysis systems for specific applications. Manipulation of the bio-particles is the key ingredient for these applications. Therefore, microfluidic bio-particle manipulation has attracted a significant attention from the academic community. Considering the size of the bio-particles and the throughput of the practical applications, manipulation of the bio-particles is a challenging problem. Different techniques are available for the manipulation of bio-particles in microfluidic systems. In this review, some of the techniques for the manipulation of bio-particles; namely hydrodynamic based, electrokinetic-based, acoustic-based, magnetic-based and optical-based methods have been discussed. The comparison of different techniques and the recent applications regarding the microfluidic bio-particle manipulation for different biotechnology applications are presented. Finally, challenges and the future research directions for microfluidic bio-particle manipulation are addressed.

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Effect of Joule heating on electrokinetic transport

Cited by 100 publications

References 63 publications

Joule heating effects on electroosmotic flow in insulator‐based dielectrophoresis

Joule heating effects on electroosmotic flow in insulator‐based dielectrophoresis

An integrated acoustic and dielectrophoretic particle manipulation in a microfluidic device for particle wash and separation fabricated by mechanical machining

Microfluidic bio-particle manipulation for biotechnology

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