Effect of Jyotiṣmatī seed oil on spatial and fear memory using scopolamine induced amnesia in mice

Raut, Sanket B; Parekar, Reshma R; Jadhav, Kshitij S.; Marathe, Padmaja A; Rege, Nirmala N

doi:10.4103/0257-7941.157149

Cited by 20 publications

(3 citation statements)

References 7 publications

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“…Kalyanaka Ghrita also reduces acetylcholinesterase levels, oxidative stress, and inflammatory cytokines in the brain [ 44 ]. Similarly, Jyotismati oil along with ghee showed significant enhancement in spatial and fear memory in rats [ 45 ]. Sarasvata Ghrita exhibits neuroprotective activity by reducing malondialdehyde levels, increasing antioxidant enzyme levels, inhibiting acetylcholinesterase activity, and promoting the release of brain-derived neurotrophic factor [ 46 ].…”

Section: Review Of Modern Literature On Ghee In Context Of the 15 Ben...mentioning

confidence: 99%

Health benefits of ghee: Review of Ayurveda and modern science perspectives

Kataria,

Singh

2024

Journal of Ayurveda and Integrative Medicine

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Section: Review Of Modern Literature On Ghee In Context Of the 15 Ben...mentioning

confidence: 99%

Health benefits of ghee: Review of Ayurveda and modern science perspectives

Kataria,

Singh

2024

Journal of Ayurveda and Integrative Medicine

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“…All biochemical parameters were evaluated and found the significant inhibition in AchE, malondialdehyd (MDA) levels significantly increased, and superoxide dismutas (SOD) also reduced. Result concluded that Celastrus paniculatus has potent anti-Alzheimer’s disease activity …”

Section: Promising Natural Products Against Alzheimer’s Diseasementioning

confidence: 99%

Evolving Role of Natural Products from Traditional Medicinal Herbs in the Treatment of Alzheimer’s Disease

Pandey

Rangra

Singh

et al. 2021

ACS Chem. Neurosci.

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Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease that causes dementia by impairing mental capacity growth and disrupting neurocognitive activity. Despite recent advancements in AD therapy, therapeutic effectiveness has been small, noncurative, and susceptible to drug resistance. The reality that AD’s origin remains unknown and that the blood-brain barrier limits treatment effectiveness are two significant impediments to science. Plants are repositories for novel chemical entities, which provide an exciting avenue for Alzheimer’s disease studies. Although several herbal remedies are unquestionably efficient, only a small number have been clinically tested for their active chemical constituents and biological activities. Using published data in the literature, we summarized commonly used medicinal plants and herbs and their phyto components for the care and diagnosis of Alzheimer’s disease as an alternative therapy. In this, we summarize the main compounds found in 30 different herbal medicines that target neurodegenerative diseases. Using the experimental study of physicochemical properties, we put forward a hypothesis about potential medicinal plants and the management of Alzheimer’s disease. The summary analysis demonstrates that conventional herbal medicines produce compounds with physicochemical properties with a high degree of similarities with existing approved medicines.

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“…The aqueous seed extract improved memory performance in elevated plus maze and in sodium nitrite induced amnesia by reducing the AChE activity [ 181 ]. Furthermore, C. paniculatus seed oil treatment showed memory improvement in scopolamine induced amnesia in mice [ 182 ]. C. paniculatus has not undergone clinical trials for safety and efficacy.…”

Section: Herbal Medicines For Alzheimer’s Disease Experimental Anmentioning

confidence: 99%

Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment

et al. 2020

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Cognitive impairment, associated with ageing, stress, hypertension and various neurodegenerative disorders including Parkinson’s disease and epilepsy, is a major health issue. The present review focuses on Alzheimer’s disease (AD), since it is the most important cause of cognitive impairment. It is characterized by progressive memory loss, language deficits, depression, agitation, mood disturbances and psychosis. Although the hallmarks of AD are cholinergic dysfunction, β-amyloid plaques and neurofibrillary tangle formation, it is also associated with derangement of other neurotransmitters, elevated levels of advanced glycation end products, oxidative damage, neuroinflammation, genetic and environmental factors. On one hand, this complex etiopathology makes a response to commonly used drugs such as donepezil, rivastigmine, galantamine and memantine less predictable and often unsatisfactory. On the other hand, it supports the use of herbal medicines due to their nonspecific antioxidant and anti-inflammatory activity and specific cholinesterase inhibitory activity. The popularity of herbal medicines is also increasing due to their perceived effectiveness, safety and affordability. In the present article, the experimental and clinical evidence have been reviewed for various Indian herbal medicines such as Centella asiatica, Bacopa monnieri, Curcuma longa, Clitoria ternatea, Withania somnifera, Celastrus paniculatus, Evolvulus alsinoides, Desmodium gangeticum, Eclipta alba, Moringa oleifera and Convolvulus pluricaulis, which have shown potential in cognitive impairment. Some commonly available herbal formulations for memory impairment in India have also been reviewed.

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Effect of Jyotiṣmatī seed oil on spatial and fear memory using scopolamine induced amnesia in mice

Cited by 20 publications

References 7 publications

Health benefits of ghee: Review of Ayurveda and modern science perspectives

Health benefits of ghee: Review of Ayurveda and modern science perspectives

Evolving Role of Natural Products from Traditional Medicinal Herbs in the Treatment of Alzheimer’s Disease

Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment

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