Effect of ketorolac tromethamine combined with dezocine prior administration on hemodynamics and postoperative analgesia in patients undergoing laparoscopic hernia repair

Abstract

Objective: To observe the effect of Ketorolac tromethamine combined with dezocine prior administration on hemodynamics and postoperative sedation in patients undergoing laparoscopic hernia repair. Methods: 100 male patients aged 60 to 80 years old, a line to elective laparoscopic inguinal hernia repair, were randomly divided into four groups: control group (Group A) and dezocine group (Group B), ketorolac tromethamine group (Group C), ketorolac tromethamine combined with dezocine group (Group D). Patients were administrated with 0.1 mg/kg dezocine in Group B, 0.5 mg/kg ketorolac in Group C, 0.1 mg/kg dezocine, and 0.5 mg/kg ketorolac in Group D, and with an equal dose of normal saline in group A. The heart rate (HR) and mean arterial pressure (MAP) of patients in 4 groups were recorded at each time point as follows, T0 (enter the operating room), T1 (before skin resection), 10 min after pneumoperitoneum (T2), mesh placement (T3), and laryngeal mask extraction (T4). Operation time, awakening time (time from drug withdrawal to consciousness recovery), the dosage of propofol, sufentanil, remifentanil, and intraoperative vasoactive drug dosage were recorded to compare. Visual analog scale score and sedation Ramsay score were evaluated 1, 6, 12, and 24 hours after extubation. Results: There was no significant difference in operation time, anesthesia recovery time, sufentanil dosage, and vasoactive drugs among all groups. The amount of propofol in Group B and D was less than that in Group A and C ( P < .05), and there was no difference between Group B and D, A and C ( P > .05). The amount of remifentanil in Group B, C, and D was less than that in Group A ( P < .05), and Group D was less than B and C ( P < .05). After extubation, HR and MAP were significantly higher than before ( P < .05). Compared with T0, HR and MAP increased in each group at T4, but MAP and HR in Group D increased the least ( P < .05). There were significant differences between Group B, C, D, and A, MAP and HR fluctuated little during extubation ( P < .05), but there was a significant difference between Group D and B, C ( P < .05). Visual analog scale scores of Group B, C, and D were lower than those of A at 1, 6, and 12 hours after surgery ( P < .05), and there was a significant difference between Group D, and B, C ( P < .05). Ramsay scores in Group B and D were higher than those in A and C at 1 and 6 hours after the operation ( P < .05). There was no difference in the incidence of adverse reactions among groups. Conclusion: The prophylactic use of ketorolac tromethamine and dezocine before laparoscopic inguinal hernia repair can reduc...

Risks of serious adverse events with non‐steroidal anti‐inflammatory drugs in gastrointestinal surgery: A systematic review with meta‐analysis and trial sequential analysis

“…Of the included trials, 89 did not mention SAEs, 28–116 and two trials mentioned potential SAEs without specifying in which intervention group these events occurred 117,118 . Lack of response to email inquiries meant these studies could not provide relevant or quantifiable data for any of our outcomes.…”