Effect of KSG-504, a new CCK-A-receptor antagonist, on experimental acute pancreatitis in rats and mice.

Kobayashi, Mamoru; Shinagawa, Kazuhiko; Sugiura, M.; Nagasawa, Tatsuya; Akahane, Masuo; Ajisawa, Yukiyoshi

doi:10.1254/fpj.107.183

Folia Pharmacologica Japonica

1996

DOI: 10.1254/fpj.107.183

|View full text |Cite

Effect of KSG-504, a new CCK-A-receptor antagonist, on experimental acute pancreatitis in rats and mice.

Mamoru Kobayashi¹,

Kazuhiko Shinagawa²,

M. Sugiura³

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1999

2000

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Role of Cholecystokinin in the Development and Progression of Acute Pancreatitis and the Potential of Therapeutic Application of Cholecystokinin Receptor Antagonists

Niederau

Grendell

1999

Digestion

View full text Add to dashboard Cite

This presentation reviews the role of cholecystokinin (CCK) as a contributory factor for the development and progression of acute pancreatitis (AP) and the perspective of CCK receptor antagonists for treatment of AP. High, supraphysiological concentrations of CCK induce AP in various species including man. There is also evidence that physiological increases in plasma CCK deteriorates AP in several animal models. The latter findings support the hypothesis that CCK plays a contributory or permissive role for the development of AP. The majorities of experimental studies show that the prophylactic and therapeutic use of CCK antagonists ameliorates AP. The latter effects were clearly shown for models of biliary AP in which plasma CCK is increased due to a feedback mechanism. However, CCK antagonists also had beneficial effects in models in which plasma CCK is not increased. In animal strains which do not have a CCK-A-receptor due to a genetic abnormality AP induced by a certain noxious factor does not develop to the same severity when compared to animals with a normal CCK-A-receptor. Thus, CCK acts as a permissive or contributory factor for the development and progression of AP. There is also evidence that CCK antagonists have a potential therapeutic benefit. Clinical studies will evaluate their therapeutic potential for patients with AP.

show abstract

Role of Cholecystokinin in the Development and Progression of Acute Pancreatitis and the Potential of Therapeutic Application of Cholecystokinin Receptor Antagonists

Niederau

Grendell

1999

Digestion

View full text Add to dashboard Cite

show abstract

Cholecystokinin in Acute Alcoholic and Biliary Pancreatitis

Räty

Sand

Kemppainen

et al. 2000

IJGC

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Effect of KSG-504, a new CCK-A-receptor antagonist, on experimental acute pancreatitis in rats and mice.

Cited by 2 publications

References 18 publications

Role of Cholecystokinin in the Development and Progression of Acute Pancreatitis and the Potential of Therapeutic Application of Cholecystokinin Receptor Antagonists

Role of Cholecystokinin in the Development and Progression of Acute Pancreatitis and the Potential of Therapeutic Application of Cholecystokinin Receptor Antagonists

Cholecystokinin in Acute Alcoholic and Biliary Pancreatitis

Contact Info

Product

Resources

About