Effect of L-Arginine on Oxygen Balance of the Liver and the Bile Secretion Function

Yanchuk, Petro I.; Bondzyk, Olena V.; Reshetnik, E.M.; Veselsky, S.P.

doi:10.1615/intjphyspathophys.v5.i2.40

Cited by 2 publications

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“…Blood pressure in the carotid artery (BP) and portal vein (PVP) were measured with an electromanometer EMT-31, the changes in the liver blood supply (HBF) -by a rheographic method in our modification [25] using a rheograph RG-4-01. Local blood flow in the liver (LBF) was stu died by a method of hydrogen clearance with its electrochemical generation [15], using a pair of platinum electrodes (generating and recording) and a polarograph LP-9. The recording electrode was polarized by a voltage of 250-300 mV.…”

Section: Methodsmentioning

confidence: 99%

“…Because the liver is one of the most multifunctional and metabolically active organs, most of the synthetic processes in it occur with increased intensity of tissue respiration. In particular, such a specific function of the liver as the formation and secretion of bile directly depends on the oxygen-dependent processes [12][13][14][15][16]. These include the synthesis of bile acids and lipids, which are the main components of bile [17,18], as well as the transport of its individual organic components [19].…”

Section: Introductionmentioning

confidence: 99%

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Role of hydrogen sulfide in the regulation of respiration, blood flow and bile secretory function of the liver

Yanchuk¹,

Komarov²,

Levadianska³

et al. 2021

Fiziol Zh

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In acute experiments on laboratory rats, intra-portal administration of L-cysteine (20 mg/kg), the precursor of hydrogen sulfide synthesis, stimulated oxygen consumption of liver by 38.6% and reduced oxygen tension by 37.1%. Activation of tissue respiration occurred due to the strengthening of oxygen-dependent synthetic processes in liver, in particular those associated with mitochondrial enzyme-catalysed bile acid biosynthesis through the acidic pathway. The concentrations of taurocholic acid and mixtures of taurodeoxycholic and taurohenodeoxycholic acids increased by 10.3 and 17.9%, respectively, compared to the initial levels. In addition, the level of free cholesterol was decreased by 33.9% and esterification processes were intensified, as indicated by an increase in the concentration of esterified cholesterol by 22.6% in the bile of rats. The latter was to some extent confirmed by a decrease in the level of free bile acids (by 15.8%) involved in the biosynthesis of cholesterol esters and intensification of tissue respiration in the liver. L-cysteine dilated intrahepatic vessels, resulting in a significant decrease of the systemic blood pressure and blood pressure in the portal vein by 17.6 and 24.5%, respectively. L-cysteine increased the rate of local blood flow in the liver and blood supply by 28.2 and 24.4%, respectively. Blockade of cystathionine-γ-lyase by DL-propargylglycine (11 mg/kg) significantly inhibited the L-cysteine-induced tissue respiration and bile acid biosynthesis in the liver. Administration of DL-propargylglycine resulted in constriction of blood vessels of the liver and, as a consequence, to an increased blood pressure and a decreased blood flow rate in tissue. Our data point to an involvement of hydrogen sulfide in the regulation of liver tissue respiration and bile secretory function.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Role of hydrogen sulfide in the regulation of respiration, blood flow and bile secretory function of the liver

Yanchuk¹,

Komarov²,

Levadianska³

et al. 2021

Fiziol Zh

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show abstract

“…Тому зниження рівня рО 2 в залозі поряд із зростан-ням постачання до неї О 2 може свідчити про збільшення споживання кисню печінкою під впливом серотоніну. Подібні зміни дослід-жуваних показників при дії гуморальних чинників ми спостерігали раніше [18].…”

Section: результати та їх обговоренняunclassified

Role of Serotonin in the Regulation of Respiration and Bile Secretory Function of the Liver

Yanchuk¹,

Athamnah²,

Reshetnik³

et al. 2015

Fiziol Zh

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Effect of L-Arginine on Oxygen Balance of the Liver and the Bile Secretion Function

Cited by 2 publications

References 0 publications

Role of hydrogen sulfide in the regulation of respiration, blood flow and bile secretory function of the liver

Role of hydrogen sulfide in the regulation of respiration, blood flow and bile secretory function of the liver

Role of Serotonin in the Regulation of Respiration and Bile Secretory Function of the Liver

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